INT6661

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 7.12
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
neurons 4
macrophages 2
liver 2
hepatocyte 2
bone marrow 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 10 99.98 Very High Very High Very High
Anterior cingulate cortex 298 99.44 Very High Very High Very High
Pain 81 99.38 Very High Very High Very High
cytokine 79 98.52 Very High Very High Very High
Somatosensory cortex 6 96.96 Very High Very High Very High
amygdala 24 95.00 High High
COX-2 inhibitor 6 92.00 High High
cINOD 23 88.72 High High
Hippocampus 2 87.44 High High
rheumatoid arthritis 67 84.68 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 57 100.00 Very High Very High Very High
Death 24 99.98 Very High Very High Very High
Injury 21 99.98 Very High Very High Very High
Shock 13 99.60 Very High Very High Very High
Hepatotoxicity 2 98.88 Very High Very High Very High
Cancer 70 98.72 Very High Very High Very High
Apoptosis 193 98.12 Very High Very High Very High
Glioma 2 98.08 Very High Very High Very High
Infection 93 97.28 Very High Very High Very High
Stress 84 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition or enhancement of the TPA-induced activation of AP-1 by methoxy-substituted trans-stilbenes
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
1) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Assay of the activities of substituted trans-stilbeness as inhibitors of the TPA-induced activation of AP-1
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
2) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Anti-oxidant activities of enhancers and inhibitors of TPA-induced activation of AP-1
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
3) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.17 Pain Relevance 0.08
Inhibition or enhancement of the TPA-induced activation of AP-1 by substituted trans-stilbenes devoid of hydroxy or methoxy functional groups
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
4) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Several of these, such as 44and 45, which contained methyl of trifluoromethyl groups on one of the aromatic rings, were effective enhancers of the TPA-induced activation of AP-1, comparable to resveratrol.
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
5) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Inhibition or enhancement of the TPA-induced activation of AP-1 by analogs of trans-stilbenes
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
6) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
As is the case with trans-stilbenes that inhibit the TPA-induced activation of AP-1, there is no required role for anti-oxidant activity.
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
7) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Inhibition or enhancement of the TPA-induced activation of AP-1 by para-methoxy-substituted trans-stilbenes
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
8) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
By comparison, 7, which is isomeric with 1, enhanced the TPA-induced activation of AP-1 2.5-fold.
Positive_regulation (enhanced) of Positive_regulation (activation) of AP-1
9) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Numerous trans-stilbenes devoid of anti-oxidant activity in the TRAP and FRAP assays were able to suppress the TPA-induced activation of AP-1, including many of the more potent compounds (Table 1).
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
10) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Inhibition or enhancement of the TPA-induced activation of AP-1 by resveratrol and phenolic trans-stilbenes
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
11) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Some of these trans-stilbenes, such as 8, 9, 10and 11, were strong inhibitors of the TPA-induced activation of AP-1 with IC50 values in the range 0.7 to 3.8 ?
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
12) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Resveratrol and 7 trans-stilbenes that contained one or more phenolic substituents were compared for their effects on the TPA-induced activation of AP-1 in an initial screening at 15 ?
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
13) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
By comparison, 7, which is isomeric with 1, enhanced the TPA-induced activation of AP-1 2.5-fold.
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
14) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Inhibition or enhancement of the TPA-induced activation of AP-1 by para-methoxy-substituted trans-stilbenes
Positive_regulation (enhancement) of Positive_regulation (activation) of AP-1
15) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Clearly, structures of inhibitors or enhancers of the TPA-induced activation of AP-1 can differ considerable from a strict trans-stilbene scaffold.


Positive_regulation (induced) of Positive_regulation (activation) of AP-1
16) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.11 Pain Relevance 0.06
The question of the role of anti-oxidant activity in those substituted trans-stilbenes that enhance the TPA-induced activation of AP-1 was also addressed (Table 2).
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
17) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
In this series, many compounds were strong inhibitors of the TPA-induced activation of AP-1, such as 46, 47, 48, 49and 51(Table 1).
Positive_regulation (induced) of Positive_regulation (activation) of AP-1
18) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Interestingly, the induction of immediate early genes c-Fos and Egr-1 which can function as sensors for duration of Erk1/2 signaling [20] was reduced in c-Met mutant mice, particularly at the later time points of liver regeneration (Figure S3).
Positive_regulation (function) of Positive_regulation (induction) of immediate early in liver
19) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.05 Pain Relevance 0
In some studies, resveratrol induced rather than inhibited protein expression; resveratrol induced COX-2 expression and nuclear accumulation in breast cancer cells through activation of MAP kinases and AP-1 [29].
Positive_regulation (induced) of Positive_regulation (activation) of AP-1 associated with breast cancer
20) Confidence 0.46 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.41 Pain Relevance 0

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