INT66611

Context Info Confidence 0.65 First Reported 1996 Last Reported 2009 Negated 0 Speculated 1 Reported most in Abstract Documents 22 Total Number 23 Disease Relevance 7.04 Pain Relevance 14.64

molecular_function (Cfp) cellular_component (Cfp) biological_process (Cfp)

Anatomy Link Frequency prefrontal 3 PFC 2 anterior 1 STR 1 brain 1 Cfp (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 354 100.00 noradrenaline 210 100.00 Locus ceruleus 140 100.00 Nucleus accumbens 118 100.00 Calcitonin gene-related peptide 15 100.00 Glutamate 8 99.98 Serotonin 39 99.84 Nicotine 15 99.70 agonist 31 98.48 Action potential 4 98.36

Disease Link Frequency Relevance Heat Pressure Volume 2 Under Development 48 99.56 Stress 59 99.50 Schizophrenia 14 94.32 Cognitive Disorder 39 93.64 Decapitation 1 93.28 Poisoning 1 92.64 Dislocations 1 87.64 Anxiety Disorder 20 86.44 Affective Disorder 3 81.72 Headache 2 80.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Does the transient PFC-NA core synchronization reflect the ability of brief epochs of PFC activity to drive up states in NA MSNs?

Localization (synchronization) of PFC-NA associated with nucleus accumbens

1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.70

The indication criteria of drainage by CT are as follow: PFC was located < 10 mm from intestinal wall, and no intervening vessels were located between PFC and the intestinal wall.

Localization (located) of PFC in vessels

2) Confidence 0.63 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710379 Disease Relevance 0.06 Pain Relevance 0.11

The observed functional coupling between DA and PFC neurons further suggests that these pathways not only allow a bidirectional control of DA neurons by the PFC, but also enable action potential-dependent DA release to be coordinated, on a subsecond timescale, with glutamate release from PFC terminals.

Localization (release) of PFC in PFC associated with action potential, glutamate and dopamine

3) Confidence 0.61 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17507563 Disease Relevance 0 Pain Relevance 0.83

Both the medial (prelimbic, infralimbic and anterior cingulate cortex) and orbitolateral (ventral orbital, ventrolateral orbital, lateral orbital, agranular insular) PFC were completely removed in three adjacent (anterior–posterior from frontal pole to genu of the corpus callosum) slices as well as a single control area (motor cortex, M-2; Paxinos and Watson 1998; Uylings et al. 2003).

Localization (removed) of PFC in anterior associated with anterior cingulate cortex

4) Confidence 0.61 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0.09 Pain Relevance 0.05

A rural town in western New York was the site of a release of a mixture of 2-chloro-6-fluorophenol (CFP), toluene and water due to a pressure build-up at a nearby chemical facility.

Localization (release) of CFP

5) Confidence 0.61 Published 2003 Journal Vet Hum Toxicol Section Abstract Doc Link 12583699 Disease Relevance 0.48 Pain Relevance 0.08

The present study was undertaken to investigate and compare the properties of noradrenaline release in the locus coeruleus (LC) and prefrontal cortex (PFC).

Spec (investigate) Localization (release) of PFC in locus coeruleus associated with locus ceruleus and noradrenaline

6) Confidence 0.57 Published 2001 Journal Brain Res. Section Abstract Doc Link 11430860 Disease Relevance 0 Pain Relevance 0.74

Handling stimulated the release of dopamine in the mPFC to about 160% of control.

Localization (release) of mPFC associated with dopamine

7) Confidence 0.48 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10463333 Disease Relevance 0.92 Pain Relevance 1.06

The effects of two different types of stress (hypotension and handling) on the release of dopamine, noradrenaline and DOPAC in the locus coeruleus (LC) and medial prefrontal cortex (mPFC) was studied by means of the dual-probe microdialysis technique.

Localization (release) of mPFC in prefrontal associated with stress, dopamine, pressure volume 2 under development, locus ceruleus and noradrenaline

8) Confidence 0.48 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10463333 Disease Relevance 0.47 Pain Relevance 0.54

Hypotension also strongly stimulated the release of dopamine in the mPFC (to 320% of control) and DOPAC in the LC (to 270% of control).

Localization (release) of mPFC associated with dopamine, pressure volume 2 under development and locus ceruleus

9) Confidence 0.48 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10463333 Disease Relevance 0.78 Pain Relevance 0.95

Handling stress (10 min) stimulated the release of noradrenaline in the LC and mPFC to 180% and 160% of control values, respectively.

Localization (release) of mPFC associated with stress, locus ceruleus and noradrenaline

10) Confidence 0.48 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10463333 Disease Relevance 0.87 Pain Relevance 1.05

Hypotension (20 min) induced by intravenous administration of nitroprusside stimulated the release of noradrenaline in the LC and mPFC to about 190% and 150%, of control values, respectively.

Localization (release) of mPFC associated with pressure volume 2 under development, locus ceruleus and noradrenaline

11) Confidence 0.48 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10463333 Disease Relevance 0.75 Pain Relevance 0.85

Lesioning of the noradrenergic neurons had no effect on the stimulatory effect of handling on the release of dopamine in the mPFC.

Localization (release) of mPFC in neurons associated with dopamine

12) Confidence 0.48 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10463333 Disease Relevance 0.85 Pain Relevance 0.89

The effects of four nAChR agonists, nicotine (NIC), 1,1-dimethyl-4-phenylpiperzinium iodide (DMPP), cytisine (CYT) and epibatidine (EPI) were investigated on [3H]-norepinephrine (NE), [3H]-dopamine (DA) and [3H]-serotonin (5-HT) release from rat prefrontal cortical (PFC) slices.

Localization (release) of PFC in prefrontal associated with dopamine, nicotine, agonist and serotonin

13) Confidence 0.34 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568345 Disease Relevance 0 Pain Relevance 1.02

In the present experiments, the baseline levels of 5-HT release in PFC and DG were similar in LE- and HE-rats, and no differences were detected in PCA-induced depolarization-independent 5-HT release in these regions.

Localization (release) of PFC

14) Confidence 0.31 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.42 Pain Relevance 0.10

There is a great deal of evidence for a coupling between the release of DA and NA in the mPFC under different conditions including stress [14-16], antidepressants [32,33], psychostimulants [34,35], antipsychotic drugs [9,36,37], ?

Localization (release) of mPFC associated with stress, antidepressant, dopamine and noradrenaline

15) Confidence 0.16 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1134661 Disease Relevance 0.10 Pain Relevance 0.91

This study analyses the effect of both single train and repeated electrical stimulation of LC on NA and DA release in the medial prefrontal cortex (mPFC), occipital cortex (Occ), and caudate nucleus.

Localization (release) of mPFC in cortex associated with dopamine, locus ceruleus and noradrenaline

16) Confidence 0.16 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1134661 Disease Relevance 0 Pain Relevance 1.03

Measurement of Free Tubulin—Free tubulin from PFC cultures was extracted as described previously (21).

Localization (Measurement) of PFC

17) Confidence 0.07 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0.08 Pain Relevance 0.06

The atypical APD-induced preferential release of DA, but not ACh, in the mPFC is partially inhibited by the selective 5-HT(1A) antagonist WAY100635.

Localization (release) of mPFC associated with dopamine and antagonist

18) Confidence 0.03 Published 2004 Journal Brain Res. Section Abstract Doc Link 15364019 Disease Relevance 0.26 Pain Relevance 0.51

Haloperidol produced a slight increase in ACh release in the vHIP at 1 mg/kg, and DA release in the mPFC at 0.1 mg/kg.

Localization (release) of mPFC associated with dopamine

19) Confidence 0.03 Published 2004 Journal Brain Res. Section Abstract Doc Link 15364019 Disease Relevance 0.33 Pain Relevance 0.73

This advantage has been attributed, in part, to the ability of the atypical APDs to markedly increase acetylcholine (ACh) and dopamine (DA) release in rat medial prefrontal cortex (mPFC), while producing a minimal effect in the nucleus accumbens (NAC) or striatum.

Localization (release) of mPFC in prefrontal associated with nucleus accumbens and dopamine

20) Confidence 0.03 Published 2004 Journal Brain Res. Section Abstract Doc Link 15364019 Disease Relevance 0.26 Pain Relevance 0.41

General Comments

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