INT66617

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Context Info
Confidence 0.80
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.35
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (HTR2A) aging (HTR2A) plasma membrane (HTR2A)
response to stress (HTR2A) cytoplasm (HTR2A) signal transducer activity (HTR2A)
Anatomy Link Frequency
N1E-115 1
locus coeruleus 1
uterine artery 1
HTR2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 14 100.00 Very High Very High Very High
Serotonin 9 100.00 Very High Very High Very High
Neurotransmitter 5 99.98 Very High Very High Very High
Migraine 6 97.84 Very High Very High Very High
Locus ceruleus 4 97.40 Very High Very High Very High
fluoxetine 115 96.34 Very High Very High Very High
antidepressant 74 95.64 Very High Very High Very High
depression 85 92.24 High High
Sumatriptan 3 89.88 High High
gABA 2 89.44 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 99.48 Very High Very High Very High
Migraine Without Aura 2 98.12 Very High Very High Very High
Headache 4 94.76 High High
Manic Depressive Disorder 45 94.36 High High
Recurrence 4 92.68 High High
Depression 112 92.24 High High
Mental Disorders 1 76.72 Quite High
Schizophrenia 47 50.00 Quite Low
Urological Neuroanatomy 1 27.28 Quite Low
Cognitive Disorder 4 21.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blots revealed a localization of the 5-HT3 receptor protein exclusively in the low buoyant density (LBD) fractions compatible with a localization within raft-like domains.
Localization (localization) of 5-HT3 receptor
1) Confidence 0.80 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16267227 Disease Relevance 0.10 Pain Relevance 0.50
Results from this study exclude the HTR2A gene, which has been localized to chromosome 13q14-q21, for involvement with common migraine.
Localization (localized) of HTR2A gene associated with migraine and migraine without aura
2) Confidence 0.78 Published 1996 Journal Cephalalgia Section Abstract Doc Link 8933989 Disease Relevance 0.45 Pain Relevance 0.48
The results indicate that the contractile serotonergic receptor population in the human uterine artery mainly comprises 5-HT2 receptors, although a minor contribution of contractile 5-HT1 receptors cannot be excluded.
Localization (contribution) of 5-HT2 in uterine artery
3) Confidence 0.73 Published 1997 Journal Hum. Reprod. Section Abstract Doc Link 9070726 Disease Relevance 0 Pain Relevance 0.48
In the presence of 5-HT reuptake inhibition, 5-HT2A receptor antagonism has been shown to enhance 5-HT and NE release in rodents.42 In preclinical models, chronic administration of FLX alone suppressed locus coeruleus neuronal activity while acutely administered OLZ significantly increased locus coeruleus firing.43 The combination of FLX + OLZ, however, resulted in enhanced locus coeruleus firing during both acute and chronic administration.43 Increased NE release may be predicted by antagonism of the aforementioned 5-HT2A dependent reduction in NE neuronal firing, while increased NE release may then enhance 5-HT neuronal firing via activation of postsynaptic ?
Localization (reduction) of 5-HT2A in locus coeruleus associated with locus ceruleus and fluoxetine
4) Confidence 0.73 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2706569 Disease Relevance 0.08 Pain Relevance 1.04
Olanzapine is a thienobenzodiazepine analog that binds to a large number of neurotransmitter receptors, including the dopamine D1, D2, and D4 receptors, serotonin 5-HT2A, 5-HT2C, 5-HT6, and 5-HT3 receptors, histamine H1 receptor, muscarinic receptors, ?
Localization (receptors) of 5-HT2A associated with dopamine, neurotransmitter and serotonin
5) Confidence 0.73 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987508 Disease Relevance 0.63 Pain Relevance 0.37
To further investigate the mechanisms underlying the noncompetitive inhibition of the serotonin-evoked cation current, we quantified the concentrations of different types of antidepressants and antipsychotics in fractions of sucrose flotation gradients isolated from HEK293 (human embryonic kidney 293) cells stably transfected with the 5-HT3A receptor and of N1E-115 neuroblastoma cells in relation to the localization of the 5-HT3 receptor protein within the cell membrane.
Localization (localization) of 5-HT3 receptor in N1E-115 associated with neuroblastoma, antidepressant and serotonin
6) Confidence 0.70 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16267227 Disease Relevance 0.10 Pain Relevance 0.46

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