INT66630

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2008
Negated 4
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.74
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3) signal transducer activity (Ptger3)
Anatomy Link Frequency
brain 2
Ptger3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe 2 100.00 Very High Very High Very High
agonist 31 96.16 Very High Very High Very High
substance P 8 95.28 Very High Very High Very High
Neuropeptide 2 91.28 High High
dorsal root ganglion 84 89.24 High High
Central nervous system 4 88.20 High High
qutenza 7 87.28 High High
Hippocampus 1 86.56 High High
Spinal cord 5 83.36 Quite High
Serotonin 1 79.92 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 88 89.24 High High
Convulsion 1 83.36 Quite High
Pain 13 77.80 Quite High
INFLAMMATION 32 71.88 Quite High
Nociception 37 70.12 Quite High
Nervous System Injury 24 30.40 Quite Low
Injury 4 20.96 Low Low
Hyperalgesia 28 10.72 Low Low
Neuropathic Pain 32 10.04 Low Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A whole-cell current-clamp study using a thin slice preparation of the rat brain was carried out to elucidate the function of prostaglandin E (PGE) receptor EP3 subtype in the dorsal raphe nucleus (DR), where mRNA of this subtype is highly expressed.
Transcription (expressed) of EP3 in brain associated with raphe
1) Confidence 0.67 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8935703 Disease Relevance 0 Pain Relevance 0.34
Moreover, most of the cells expressing EP2 or EP3 mRNA were of small to medium diameter (< 30 microm).
Transcription (expressing) of EP3
2) Confidence 0.49 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.14 Pain Relevance 0.56
Given that EP3A and EP3B mRNA are not found in DRGs [39] and EP3C (i.e., EP3?)
Neg (not) Transcription (found) of EP3B
3) Confidence 0.32 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.32 Pain Relevance 0.35
Given that EP3A and EP3B mRNA are not found in DRGs [39] and EP3C (i.e., EP3?)
Neg (not) Transcription (found) of EP3A
4) Confidence 0.32 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.32 Pain Relevance 0.35
Given that EP3A and EP3B mRNA are not found in DRGs [39] and EP3C (i.e., EP3?)
Neg (not) Transcription (found) of EP3C
5) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.33 Pain Relevance 0.35
Given that EP3A and EP3B mRNA are not found in DRGs [39] and EP3C (i.e., EP3?)
Neg (not) Transcription (found) of EP3
6) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.33 Pain Relevance 0.35
We quantitated mRNA levels for enzymes involved in the prostaglandin biosynthetic pathways and found that both COX-2 and PGE synthase (PGEs) mRNA levels were increased in the brain; no changes were found for expression of COX-1 or PGD synthase mRNA.
Transcription (levels) of PGE synthase in brain
7) Confidence 0.10 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.30 Pain Relevance 0.42

General Comments

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