INT66646

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Context Info
Confidence 0.44
First Reported 1996
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 16.24
Pain Relevance 8.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chdh) oxidoreductase activity (Chdh)
Anatomy Link Frequency
NK cell 2
face 1
head 1
Chdh (Mus musculus)
Pain Link Frequency Relevance Heat
headache 93 100.00 Very High Very High Very High
Botox 1 98.84 Very High Very High Very High
Endep 1 98.28 Very High Very High Very High
fluoxetine 1 97.98 Very High Very High Very High
Gabapentin 1 97.50 Very High Very High Very High
Pain 3 93.00 High High
Cluster headache 2 91.52 High High
Migraine 6 91.40 High High
Angina 33 90.16 High High
anesthesia 1 85.40 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 378 100.00 Very High Very High Very High
Atherosclerosis 101 100.00 Very High Very High Very High
Coronary Heart Disease 70 100.00 Very High Very High Very High
Headache Disorders 60 100.00 Very High Very High Very High
Hiatal Hernia 8 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 321 99.90 Very High Very High Very High
Metabolic Syndrome 12 99.60 Very High Very High Very High
Headache 36 99.18 Very High Very High Very High
Temporomandibular Joint Disorders 8 99.18 Very High Very High Very High
Stress 3 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with episodic headache controls, CDH cases had more major life changes in the year before or same year as CDH onset.
Regulation (changes) of CDH associated with headache
1) Confidence 0.44 Published 2008 Journal Cephalalgia Section Abstract Doc Link 18557980 Disease Relevance 1.50 Pain Relevance 1.56
Primary CDH is a frequent entity that probably affects 4% to 5% of the population.
Regulation (affects) of CDH associated with headache
2) Confidence 0.44 Published 2001 Journal Curr Neurol Neurosci Rep Section Abstract Doc Link 11898507 Disease Relevance 1.10 Pain Relevance 1.23
To date, only topiramate, gabapentin, tizanidine, fluoxetine, amitriptyline, and botulinum toxin type A (BoNTA) have been evaluated as prophylactic treatment of CDH in randomized, double-blind, placebo-controlled, or active comparator-controlled trials.
Regulation (placebo-controlled) of CDH associated with headache, endep, gabapentin, botox and fluoxetine
3) Confidence 0.44 Published 2006 Journal Headache Section Abstract Doc Link 17115988 Disease Relevance 1.44 Pain Relevance 1.73
Primary CDH is a frequent entity that probably affects 4-5% of the population.
Regulation (affects) of CDH associated with headache
4) Confidence 0.44 Published 2005 Journal J Headache Pain Section Abstract Doc Link 16362656 Disease Relevance 1.12 Pain Relevance 1.33
The purpose of this article is to critically assess whether there is a role for fetal surgery in the treatment of CDH, and, if so, under what selected circumstances.
Spec (whether) Regulation (role) of CDH associated with hiatal hernia
5) Confidence 0.40 Published 1996 Journal Semin. Pediatr. Surg. Section Abstract Doc Link 8936656 Disease Relevance 0.67 Pain Relevance 0.09
OBJECTIVE: Temporomandibular disorder (TMD) and chronic daily headache (CDH) are chronic problems affecting the head and face.
Regulation (affecting) of CDH in face associated with headache disorders, temporomandibular joint disorders and headache
6) Confidence 0.32 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 17321447 Disease Relevance 0.55 Pain Relevance 0.37
However, similarities between episodic and CDH suggest that estrogen also may significantly influence CDH.
Spec (may) Regulation (influence) of CDH associated with headache
7) Confidence 0.27 Published 2004 Journal Curr Pain Headache Rep Section Abstract Doc Link 14731385 Disease Relevance 1.10 Pain Relevance 1.08
Few studies have evaluated the ability of gynecologic events, such as menses, to influence CDH.
Regulation (influence) of CDH associated with headache
8) Confidence 0.27 Published 2004 Journal Curr Pain Headache Rep Section Abstract Doc Link 14731385 Disease Relevance 1.09 Pain Relevance 1.00
OBJECTIVE: Temporomandibular disorder (TMD) and chronic daily headache (CDH) are chronic problems affecting the head and face.
Regulation (affecting) of CDH in head associated with headache disorders, temporomandibular joint disorders and headache
9) Confidence 0.11 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 17321447 Disease Relevance 0.55 Pain Relevance 0.37
Can the principles of Mendelian randomisation be used to deduce the effects of PON1 activity on CHD from the PON1 genotype-CHD association results?
Regulation (effects) of CHD associated with coronary artery disease
10) Confidence 0.09 Published 2004 Journal BMC Genet Section Body Doc Link PMC449704 Disease Relevance 0.91 Pain Relevance 0
However, the use of Mendelian randomisation in this instance may be complicated by the polymorphism being associated with a number of different intermediate phenotypes that could have opposing effects on CHD and by the fact that the principles of Mendelian randomisation depend upon a very clear understanding of the functional pathways from genotype, through intermediate phenotype, to disease outcome.
Regulation (effects) of CHD associated with coronary artery disease and disease
11) Confidence 0.06 Published 2004 Journal BMC Genet Section Body Doc Link PMC449704 Disease Relevance 0.66 Pain Relevance 0
If the Q192R polymorphism has pleiotropic effects (the potential for polymorphisms to have more than one specific phenotypic effect) with some, as yet unknown, phenotypic effect of the R allele that results in a decreased risk of CHD then the overall effect of this polymorphism could be null, but the antioxidant properties of PON1 activity could still be an important determinant of risk.
Regulation (effect) of CHD associated with coronary artery disease
12) Confidence 0.06 Published 2004 Journal BMC Genet Section Body Doc Link PMC449704 Disease Relevance 0.92 Pain Relevance 0
HDL: an independent CHD risk factor
Neg (independent) Regulation (independent) of CHD associated with coronary heart disease and disorder of lipid metabolism
13) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 2.26 Pain Relevance 0
KS was responsible for CHD patients examination and selection.
Spec (examination) Regulation (responsible) of CHD associated with coronary artery disease
14) Confidence 0.04 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 0.10 Pain Relevance 0
It is worthy to stress out that the Bruunsgaard's data illustrates the changes in NK cells compartment in an early atherosclerosis and not in fully symptomatic CHD, which can explain discrepancy between this report and our study.
Regulation (changes) of CHD in NK cells associated with stress, coronary artery disease and atherosclerosis
15) Confidence 0.04 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 1.04 Pain Relevance 0.09
This indicates that CHD patients are affected both by the coronary vessel disease and deficiency of NK cell activity.
Regulation (affected) of CHD in NK cell associated with coronary artery disease and disease
16) Confidence 0.02 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 1.22 Pain Relevance 0

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