INT6665

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Context Info
Confidence 0.77
First Reported 1991
Last Reported 2010
Negated 3
Speculated 9
Reported most in Abstract
Documents 520
Total Number 530
Disease Relevance 165.31
Pain Relevance 217.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
neurons 62
spinal 39
spinal cord 30
dorsal horn 23
neuronal 22
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1333 100.00 Very High Very High Very High
Inflammation 1087 100.00 Very High Very High Very High
Neuropeptide 285 100.00 Very High Very High Very High
Morphine 278 100.00 Very High Very High Very High
Periaqueductal grey 148 100.00 Very High Very High Very High
cytokine 121 100.00 Very High Very High Very High
substance P 86 100.00 Very High Very High Very High
spinal dorsal horn 79 100.00 Very High Very High Very High
Catecholamine 30 100.00 Very High Very High Very High
Spinal cord 1052 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1234 100.00 Very High Very High Very High
Cancer 747 100.00 Very High Very High Very High
Urological Neuroanatomy 553 100.00 Very High Very High Very High
Hypoxia 451 100.00 Very High Very High Very High
Lung Cancer 283 100.00 Very High Very High Very High
Breast Cancer 274 100.00 Very High Very High Very High
Adhesions 51 100.00 Very High Very High Very High
Shock 42 100.00 Very High Very High Very High
Necrosis 41 100.00 Very High Very High Very High
Generalized Anxiety Disorder 12 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following tooth pulp stimulation, Fos expression was greater in animals with inflamed teeth than in animals with non-inflamed teeth, with the greatest effect seen in the subnucleus caudalis.
Gene_expression (expression) of Fos in teeth
1) Confidence 0.77 Published 2007 Journal Eur. J. Oral Sci. Section Abstract Doc Link 17305715 Disease Relevance 0.31 Pain Relevance 0.27
We have previously carried out detailed characterization and identification of Fos expression within the trigeminal nucleus after tooth pulp stimulation in ferrets.
Gene_expression (expression) of Fos in tooth pulp
2) Confidence 0.77 Published 2007 Journal Eur. J. Oral Sci. Section Abstract Doc Link 17305715 Disease Relevance 0.23 Pain Relevance 0.19
The effect of inflammation on Fos expression in the ferret trigeminal nucleus.
Gene_expression (expression) of Fos in nucleus associated with inflammation
3) Confidence 0.77 Published 2007 Journal Eur. J. Oral Sci. Section Title Doc Link 17305715 Disease Relevance 0.32 Pain Relevance 0.24
LPS treatment did not evoke Fos expression in the rostral trigeminal regions above Vi/Vc.
Gene_expression (expression) of Fos
4) Confidence 0.77 Published 2002 Journal Pain Section Abstract Doc Link 12237184 Disease Relevance 0.45 Pain Relevance 0.30
Trigeminal c-Fos expression and behavioral responses to pulpal inflammation in ferrets.
Gene_expression (expression) of Fos associated with inflammation
5) Confidence 0.77 Published 2002 Journal Pain Section Title Doc Link 12237184 Disease Relevance 0.41 Pain Relevance 0.19
In this study, the effects of pulpal inflammation produced by bacterial lipopolysaccharide (LPS) on face-grooming behavior and trigeminal Fos expression were examined.
Gene_expression (expression) of Fos in face associated with inflammation
6) Confidence 0.77 Published 2002 Journal Pain Section Abstract Doc Link 12237184 Disease Relevance 0.41 Pain Relevance 0.20
Catecholaminergic (TH-positive) neurons expressed Fos in the porcine C1 and A1 areas of ventrolateral medulla.
Gene_expression (expressed) of Fos in neurons associated with medulla
7) Confidence 0.77 Published 1996 Journal Brain Res. Section Abstract Doc Link 8822357 Disease Relevance 0.23 Pain Relevance 0.22
It was found that electroacupuncture strongly inhibited the carrageenan-induced edema by over 60%, and suppressed the associated Fos expression in the superficial laminae (I-II) of the ipsilateral dorsal horn by 50%.
Gene_expression (expression) of Fos in dorsal horn associated with pressure and volume under development, dorsal horn and electroacupuncture
8) Confidence 0.76 Published 2004 Journal Brain Res. Bull. Section Abstract Doc Link 14709347 Disease Relevance 0.57 Pain Relevance 1.08
Neither the anti-edematous effect nor the suppression of Fos expression in the superficial spinal laminae was affected by intraperitoneal injection of the opioid antagonist naloxone.
Gene_expression (expression) of Fos in spinal associated with antagonist, narcan and opioid
9) Confidence 0.76 Published 2004 Journal Brain Res. Bull. Section Abstract Doc Link 14709347 Disease Relevance 0.53 Pain Relevance 1.09
Because Fos expression in the paradigms that were used occurs in enkephalin-negative striatonigral neurons, which show limited coexpression of D(1) and D(2) receptors, the present findings taken together suggest the intriguing possibility that D(1)/D(2) synergism may be mediated by D(1) and D(2) receptors residing on separate striatal neurons and interacting in a manner that is not dependent on action potentials.
Gene_expression (expression) of Fos in neurons associated with action potential and enkephalin
10) Confidence 0.76 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964971 Disease Relevance 0 Pain Relevance 1.00
The present study demonstrates that both xenogeneic porcine and bovine chromaffin cells transplanted into the spinal subarachnoid space of the rat can suppress formalin-evoked c-Fos expression equally, in parallel with suppression of nociceptive behaviors in the tonic phase of the test.
Gene_expression (expression) of c-Fos in spinal associated with nociception
11) Confidence 0.75 Published 2005 Journal Cell Transplant Section Abstract Doc Link 16180654 Disease Relevance 0.24 Pain Relevance 0.60
Intrathecal grafting of porcine chromaffin cells reduces formalin-evoked c-Fos expression in the rat spinal cord.
Gene_expression (expression) of c-Fos in spinal cord associated with spinal cord and intrathecal
12) Confidence 0.75 Published 2005 Journal Cell Transplant Section Title Doc Link 16180654 Disease Relevance 0.07 Pain Relevance 0.90
In the present work, by studying co-localization of c-Fos immunoreactivity and preproenkephalin and preprodynorphin transcripts, we show that co-administration of the A1 receptor agonist CPA and the A2A receptor agonist CGS 21680 increases the striatal expression of c-fos in GABAergic enkephalinergic but not in GABAergic dynorphinergic neurons.
Gene_expression (expression) of c-fos in CPA associated with gabaergic and agonist
13) Confidence 0.75 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16452987 Disease Relevance 0 Pain Relevance 0.47
The goal of the present study was to confirm porcine chromaffin cell analgesic effects at the molecular level by evaluating neural activity as reflected by spinal cord c-Fos protein expression.
Gene_expression (expression) of c-Fos in neural associated with analgesic and spinal cord
14) Confidence 0.75 Published 2005 Journal Cell Transplant Section Abstract Doc Link 16180654 Disease Relevance 0.09 Pain Relevance 0.73
To this end, the expression of c-Fos in response to intraplantar formalin injection was evaluated in animals following intrathecal grafting of 10(6) porcine or bovine chromaffin cells.
Gene_expression (expression) of c-Fos in chromaffin cells associated with intrathecal
15) Confidence 0.75 Published 2005 Journal Cell Transplant Section Abstract Doc Link 16180654 Disease Relevance 0.09 Pain Relevance 0.72
RESULTS: One week after operation, the c-fos expression strengthened in both anterior and posterior root fiber obviously.
Gene_expression (expression) of c-fos in posterior
16) Confidence 0.75 Published 2004 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 15598371 Disease Relevance 0.07 Pain Relevance 0
Surprisingly, GTN attenuated capsaicin-induced c-fos expression by 64%.
Gene_expression (expression) of c-fos associated with qutenza
17) Confidence 0.75 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.16 Pain Relevance 0.84
Neuropeptide release and the expression of c-fos like immunoreactivity (c-fos LI) within trigeminal nucleus caudalis neurons (TNC) are activation markers of the trigeminal nerve system.
Gene_expression (expression) of c-fos in neurons associated with fifth nerve and neuropeptide release
18) Confidence 0.75 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.08 Pain Relevance 0.28
CGRP release and c-fos expression within trigeminal nucleus caudalis of the rat following glyceryltrinitrate infusion.
Gene_expression (expression) of c-fos in nucleus associated with qutenza
19) Confidence 0.75 Published 2005 Journal Cephalalgia Section Title Doc Link 15689199 Disease Relevance 0.14 Pain Relevance 0.66
GTN infusion (2 microg/kg/min for 30 min) did not lead to enhanced c-fos LI after 2 h and 4 h, whereas capsaicin infusion caused a time- and dose-dependent expression of c-fos LI within laminae I and II of the TNC.
Gene_expression (expression) of c-fos in TNC associated with qutenza
20) Confidence 0.75 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.16 Pain Relevance 0.77

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