INT66651

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.31
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
2B7 1
SLC45A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 1 89.36 High High
MU agonist 1 85.00 Quite High
antagonist 3 84.40 Quite High
Buprenorphine 5 83.96 Quite High
mu opioid receptor 1 81.88 Quite High
cINOD 2 81.36 Quite High
Opioid 2 79.24 Quite High
abdominal pain 1 77.60 Quite High
headache 1 76.32 Quite High
peripheral neuropathy 1 75.52 Quite High
Disease Link Frequency Relevance Heat
Hyperbilirubinemia 2 99.40 Very High Very High Very High
Adverse Drug Reaction 1 96.64 Very High Very High Very High
Infection 2 80.72 Quite High
Vomiting 2 79.84 Quite High
Diarrhoea 1 78.40 Quite High
Abdominal Pain 1 77.60 Quite High
Headache 1 76.32 Quite High
Peripheral Neuropathy 1 75.52 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 75.00 Quite High
Exanthema 1 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An exception is an increased risk of asymptomatic hyperbilirubinemia, which is due to competitive inhibition of uridine diphosphate-glucuronosyltransferase 1A1.
Negative_regulation (inhibition) of 1A1 associated with hyperbilirubinemia
1) Confidence 0.57 Published 2004 Journal Pharmacotherapy Section Abstract Doc Link 15585441 Disease Relevance 1.19 Pain Relevance 0.19
To this end, further studies were undertaken using specific inhibitors of P450 2C9 and P450 cDNA-expressed microsomes for P450 1A1, 2A6, 2B6, 2C19, and 2D6 to assess their potential involvement.
Negative_regulation (inhibitors) of 1A1
2) Confidence 0.41 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8937439 Disease Relevance 0.07 Pain Relevance 0.19
Inhibition and active sites of UDP-glucuronosyltransferases 2B7 and 1A1.
Negative_regulation (Inhibition) of 1A1 in 2B7
3) Confidence 0.41 Published 2002 Journal Drug Metab. Dispos. Section Title Doc Link 12433804 Disease Relevance 0.06 Pain Relevance 0.74

General Comments

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