INT66653

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.46
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
2B7 3
1A2 2
eye 1
embryonic kidney 1
SLC45A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 17 99.52 Very High Very High Very High
Paracetamol 11 98.70 Very High Very High Very High
Endep 6 93.36 High High
cINOD 6 92.36 High High
Inflammation 3 91.88 High High
Analgesic 5 90.36 High High
Pain 1 90.28 High High
melanocortin 1 receptor 1 84.88 Quite High
antagonist 1 75.00 Quite High
aspirin 3 74.80 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 2 99.42 Very High Very High Very High
Liver Cancer 2 97.28 Very High Very High Very High
Leukemia 1 95.08 Very High Very High Very High
Cancer 2 94.56 High High
INFLAMMATION 3 91.88 High High
Pain 1 90.28 High High
Vomiting 1 89.68 High High
Dizziness 1 89.36 High High
Infertility 1 87.48 High High
Hepatocellular Cancer 1 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selectivity was assessed using UGTs 1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B7, and 2B15 expressed in HEK293 cells.
Gene_expression (expressed) of 1A1 in 2B7
1) Confidence 0.75 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16381668 Disease Relevance 0 Pain Relevance 0.08
The detrimental effects of TCDD are mediated via the aryl hydrocarbon receptor (AhR), a transcription factor that regulates the expression of the carcinogen-activating enzymes cytochromes P-450 (CYP) 1A1, 1A2, and 1B1.
Gene_expression (expression) of 1A1 in 1A2
2) Confidence 0.75 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.18 Pain Relevance 0.22
Sulindac treatment of Sprague-Dawley rats resulted in a dose-dependent increase in hepatic cytochrome P450 (CYP) enzyme activity and in the expression of hepatic CYPs 1A1 and 1B1 mRNA.
Gene_expression (expression) of 1A1
3) Confidence 0.75 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.18 Pain Relevance 0.12
Similarly, we observed significantly increased levels of OCA2 mRNA in rs12913832-T (brown eye) homozygotes compared to rs12913832-C (blue eye) homozygous strains, which was not observed for MATP or NCKX5 gene transcripts.
Gene_expression (transcripts) of MATP in eye associated with sprains and strains
4) Confidence 0.65 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 18650849 Disease Relevance 0.18 Pain Relevance 0.08
Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties.
Gene_expression (Contribution) of 1A1 associated with morphine
5) Confidence 0.65 Published 2008 Journal Drug Metab. Dispos. Section Title Doc Link 18187562 Disease Relevance 0 Pain Relevance 1.10
To this end, further studies were undertaken using specific inhibitors of P450 2C9 and P450 cDNA-expressed microsomes for P450 1A1, 2A6, 2B6, 2C19, and 2D6 to assess their potential involvement.
Gene_expression (expressed) of 1A1
6) Confidence 0.65 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8937439 Disease Relevance 0.07 Pain Relevance 0.18
Selectivity was assessed using UGTs 1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B7, and 2B15 expressed in HEK293 cells.
Gene_expression (expressed) of 1A1 in 2B7
7) Confidence 0.65 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16381668 Disease Relevance 0 Pain Relevance 0.08
The aim of the present study was to develop an in vitro assay for assessment of drug-drug interactions related to UGTs applicable to early drug discovery. 4-Trifluoromethylumbelliferyl was tested as a marker substrate for six human recombinant expressed UGT isoforms: 1A1, 1A3, 1A4, 1A6, 1A9, and 2B7.
Gene_expression (expressed) of 1A1 in 2B7
8) Confidence 0.65 Published 2004 Journal Assay Drug Dev Technol Section Abstract Doc Link 15357915 Disease Relevance 0 Pain Relevance 0
The genetic damage in exposed individuals was measured by means of the comet test, chromosomal alterations test, and the study of the CYP 1A1 and MSH2 genes.
Gene_expression (study) of 1A1
9) Confidence 0.65 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18991910 Disease Relevance 0.55 Pain Relevance 0.09
In the present study, we have investigated the molecular mechanism by which sulindac affects the activity and expression of the enzymes that mediate the initial detoxification steps of many environmental carcinogens, the cytochromes P450 1A1, 1A2 and 1B1.
Gene_expression (expression) of 1A1 in 1A2
10) Confidence 0.58 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.17 Pain Relevance 0.14
To address a possible role of 1A7 in APAP glucuronidation relative to other 1A forms, cDNAs encoding UGTs 1A1, 1A5, 1A6, 1A7, and 1A8 were expressed in human embryonic kidney cells and the contents of expressed enzyme in prepared membrane fractions determined by quantitative immunoblotting.
Gene_expression (expressed) of 1A1 in embryonic kidney associated with paracetamol
11) Confidence 0.58 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 11854153 Disease Relevance 0.13 Pain Relevance 0.68

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