INT6667

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Context Info
Confidence 0.77
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 6.29
Pain Relevance 5.84

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nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
T cells 3
brain 2
DRG 2
neuronal 1
glial cells 1
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 206 100.00 Very High Very High Very High
Desipramine 15 99.78 Very High Very High Very High
antidepressant 22 99.62 Very High Very High Very High
Kinase C 1 99.44 Very High Very High Very High
Anterior cingulate 1 99.10 Very High Very High Very High
fluoxetine 21 98.84 Very High Very High Very High
Anterior cingulate cortex 10 98.16 Very High Very High Very High
nMDA receptor 30 98.08 Very High Very High Very High
anesthesia 3 97.64 Very High Very High Very High
Enkephalin 2 93.36 High High
Disease Link Frequency Relevance Heat
Clear Cell Sarcoma 56 99.84 Very High Very High Very High
Cancer 98 97.64 Very High Very High Very High
Cystitis 19 95.48 Very High Very High Very High
Apoptosis 18 95.08 Very High Very High Very High
Dermatofibroma 2 94.64 High High
Injury 24 94.12 High High
Drug Induced Neurotoxicity 83 91.96 High High
Peripheral Arterial Disease 54 90.00 High High
Malignant Neoplastic Disease 4 89.92 High High
Schizophrenia 3 89.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the antidepressants had any effect on CREB expression, nor on the accumulation of cyclic AMP.
Gene_expression (expression) of CREB associated with antidepressant
1) Confidence 0.77 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.48
At nanomolar concentrations, CLOM and DMI increased expression of phospho-CREB (cyclic AMP response element binding protein).
Gene_expression (expression) of CREB associated with desipramine
2) Confidence 0.77 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.43
Quantitative RT-PCR analysis revealed no significant differences in the expression of neurotrophic factors, brain-derived neurotrophic factor (BDNF);glial-derived neurotrophic factor (GDNF) and cAMP-responsive element-binding protein (CREB) between cells treated with fluoxetine for two weeks and their untreated counterparts.
Gene_expression (expression) of CREB in brain associated with fluoxetine
3) Confidence 0.76 Published 2010 Journal Int. J. Dev. Biol. Section Abstract Doc Link 19598107 Disease Relevance 0.18 Pain Relevance 0.89
Quantitative RT-PCR analysis revealed no significant differences in the expression of neurotrophic factors, brain-derived neurotrophic factor (BDNF);glial-derived neurotrophic factor (GDNF) and cAMP-responsive element-binding protein (CREB) between cells treated with fluoxetine for two weeks and their untreated counterparts.
Gene_expression (expression) of cAMP-responsive element-binding protein in brain associated with fluoxetine
4) Confidence 0.76 Published 2010 Journal Int. J. Dev. Biol. Section Abstract Doc Link 19598107 Disease Relevance 0.18 Pain Relevance 0.89
To determine if CREB activity contributes to neuronal survival in adult anterior cingulate neurons, we inhibited CREB activity by over-expressing pCMV-CREB133, a dominant negative CREB (mCREB), in the ACC of adult mice using a newly developed method of microelectroporation [16].
Gene_expression (expressing) of CREB in anterior associated with anterior cingulate cortex and anterior cingulate
5) Confidence 0.75 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.55 Pain Relevance 0.42
These data indicate that receptor binding of endothelin-1 leads to rapid changes in the expression of immediate-early response genes which may cause more prolonged changes in the expression of AP-1 and/or CREB target genes in the nervous system.
Gene_expression (expression) of CREB in nervous system
6) Confidence 0.75 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1331650 Disease Relevance 0.14 Pain Relevance 0
Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected.
Neg (negative) Gene_expression (expresses) of CREB
7) Confidence 0.75 Published 1994 Journal Cell Section Abstract Doc Link 7923376 Disease Relevance 0 Pain Relevance 0.10
At nanomolar concentrations, CLOM and DMI increased expression of phospho-CREB (cyclic AMP response element binding protein).
Gene_expression (expression) of cyclic AMP response element binding protein associated with desipramine
8) Confidence 0.68 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.43
The importance of the CREB cascade for the development of orientation selectivity
Gene_expression (cascade) of CREB
9) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0.07
Cloning and sequencing of this product showed an in-frame fusion between EWSR1 exon 7 and CREB1 exon 7 (Fig. 3b).
Gene_expression (exon) of CREB1
10) Confidence 0.49 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 0.30 Pain Relevance 0
To further evaluate changes in CREB phosphorylation we compared pCREB/GAPDH levels of Ethanol and Ethanol+Vinpocetine animals to their controls (Figure 4c).
Gene_expression (levels) of pCREB
11) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0
EWSR1-ATF1 and EWSR1-CREB1 are not exclusively found in CCS.
Neg (not) Gene_expression (found) of CREB1 associated with clear cell sarcoma
12) Confidence 0.44 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 1.30 Pain Relevance 0
Protein expression was measured by 4°C overnight immunoblotting with diluted antibodies: extracellular signal-regulated kinase 2 (mouse monoclonal ERK2, 1:1000; Santa Cruz Biotechnology, Santa Cruz, CA), phosphorylated ERK1/2 (mouse monoclonal pERK, 1:500; Santa Cruz Biotechnology), COX-2 (goat polyclonal, 1:500; Santa Cruz Biotechnology) iNOS (rabbit polyclonal, 1:500; Santa Cruz Biotechnology) and phosphorylated CREB (rabbit polyclonal, 1:1000; AbCam, Cambridge, MA).
Gene_expression (/) of CREB
13) Confidence 0.38 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0 Pain Relevance 0
A total of 55 genes were recognized as potential targets of CREB (Figure 6B and Additional file 11).
Gene_expression (targets) of CREB
14) Confidence 0.23 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.60 Pain Relevance 0
In contrast, the expression level of extracellular signal-regulated kinase (ERK) and cAMP response element binding protein (CREB), some phosphorylated forms of signaling proteins (pCREB-S133, pCaMKII-T286/287, GluR1-S831, pGluR1-S845, pNR1-S896, pNR1-S897, pNR2B-S1303), as well as the main metabotropic glutamate receptor subunits (mGluR1, mGluR5, mGluR4, mGluR6/7) and the kainite receptor subunits (GluR6/7), were unaffected.
Gene_expression (expression) of CREB associated with glutamate receptor
15) Confidence 0.20 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2518049 Disease Relevance 0.29 Pain Relevance 0.35
In contrast, the expression level of extracellular signal-regulated kinase (ERK) and cAMP response element binding protein (CREB), some phosphorylated forms of signaling proteins (pCREB-S133, pCaMKII-T286/287, GluR1-S831, pGluR1-S845, pNR1-S896, pNR1-S897, pNR2B-S1303), as well as the main metabotropic glutamate receptor subunits (mGluR1, mGluR5, mGluR4, mGluR6/7) and the kainite receptor subunits (GluR6/7), were unaffected.
Gene_expression (expression) of cAMP response element binding protein associated with glutamate receptor
16) Confidence 0.20 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2518049 Disease Relevance 0.29 Pain Relevance 0.35
Similarly, CD4 T cells expressing a dominant-negative mutant of CREB showed defective expression of IL-2, IL-4, and IFN-?.
Gene_expression (expressing) of CREB in T cells
17) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.09 Pain Relevance 0.08
In contrast, overexpression of CREB in Jurkat T cells has been shown to downmodulate IFN-?
Gene_expression (overexpression) of CREB in T cells
18) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.08 Pain Relevance 0.24
This defect reflected the incapacity of these cells to activate CREB and the expression of the CREB-dependent immediate-early genes c-jun, fosB, fra2, and junB that are necessary for cytokine gene expression [86].
Gene_expression (expression) of CREB-dependent associated with cytokine
19) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.09 Pain Relevance 0.23
This defect reflected the incapacity of these cells to activate CREB and the expression of the CREB-dependent immediate-early genes c-jun, fosB, fra2, and junB that are necessary for cytokine gene expression [86].
Gene_expression (expression) of CREB-dependent associated with cytokine
20) Confidence 0.20 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.09 Pain Relevance 0.24

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