INT66673

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.14
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pdia3) endoplasmic reticulum (Pdia3)
Anatomy Link Frequency
uterus 1
stomach 1
lung 1
reticulum 1
Pdia3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 100.00 Very High Very High Very High
Analgesic 2 87.80 High High
Inflammation 129 73.76 Quite High
Inflammatory response 13 47.36 Quite Low
interstitial cystitis 9 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 5 99.12 Very High Very High Very High
Stomach Cancer 3 98.80 Very High Very High Very High
Nephrotoxicity 4 96.68 Very High Very High Very High
Overdose 1 91.24 High High
Hepatotoxicity 1 89.92 High High
Skin Cancer 3 80.20 Quite High
Cystitis 6 77.20 Quite High
Stress 15 75.88 Quite High
INFLAMMATION 148 73.76 Quite High
Overactive Bladder 183 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that grp58 is involved in the oncogenic transformation[53] since expression analysis revealed an up-regulation of grp58 in breast, uterus, lung, and stomach tumors [54].
Regulation (regulation) of grp58 in stomach associated with stomach cancer
1) Confidence 0.42 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.47 Pain Relevance 0.04
Associated with target organ toxicity is selective arylation of proteins, with a 58-kDa acetaminophen binding protein (58-ABP) being the most prominent cytosolic target.
Regulation (target) of 58-kDa associated with toxicity and paracetamol
2) Confidence 0.26 Published 1996 Journal Fundam Appl Toxicol Section Abstract Doc Link 8937897 Disease Relevance 0.75 Pain Relevance 0.82
In addition, we recently identified another key element of the MHC class I antigen-presentation process as a candidate target of balancing selection: endoplasmic reticulum aminopeptidase 2 (ERAP2) [3].
Regulation (target) of endoplasmic reticulum in reticulum
3) Confidence 0.26 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
It is likely that grp58 is involved in the oncogenic transformation[53] since expression analysis revealed an up-regulation of grp58 in breast, uterus, lung, and stomach tumors [54].
Regulation (regulation) of grp58 in uterus associated with stomach cancer
4) Confidence 0.14 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.47 Pain Relevance 0.04
It is likely that grp58 is involved in the oncogenic transformation[53] since expression analysis revealed an up-regulation of grp58 in breast, uterus, lung, and stomach tumors [54].
Regulation (regulation) of grp58 in lung associated with stomach cancer
5) Confidence 0.14 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.47 Pain Relevance 0.04

General Comments

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