INT6669

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2010
Negated 6
Speculated 1
Reported most in Abstract
Documents 98
Total Number 99
Disease Relevance 23.50
Pain Relevance 56.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal 18
hippocampus 8
spinal cord 8
neurons 8
hypothalamus 7
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 164 100.00 Very High Very High Very High
Morphine 130 100.00 Very High Very High Very High
Dorsal horn 63 100.00 Very High Very High Very High
Inflammation 61 100.00 Very High Very High Very High
qutenza 59 100.00 Very High Very High Very High
narcan 46 100.00 Very High Very High Very High
depression 14 100.00 Very High Very High Very High
cva 5 100.00 Very High Very High Very High
antagonist 166 99.98 Very High Very High Very High
Thalamus 16 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 122 100.00 Very High Very High Very High
Nociception 114 100.00 Very High Very High Very High
INFLAMMATION 64 100.00 Very High Very High Very High
Convulsion 18 100.00 Very High Very High Very High
Depression 14 100.00 Very High Very High Very High
Hemorrhage 5 100.00 Very High Very High Very High
Cirrhosis 7 99.70 Very High Very High Very High
Inflammatory Pain 18 99.66 Very High Very High Very High
Hypertension 6 99.42 Very High Very High Very High
Hyperalgesia 140 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When MK-801, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, was co-administered along with morphine, it inhibited the naloxone-induced increases in c-fos mRNA levels in infant rats following repeated morphine administration.
Negative_regulation (inhibited) of Positive_regulation (increases) of c-fos mRNA associated with antagonist, narcan and morphine
1) Confidence 0.59 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12499582 Disease Relevance 0.28 Pain Relevance 1.16
When used with halothane anesthesia, relatively low doses of Dex (1-3 microg) completely suppressed Fos induction in the superficial spinal layers.
Negative_regulation (suppressed) of Positive_regulation (induction) of Fos in spinal associated with anesthesia and halothane
2) Confidence 0.58 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12749994 Disease Relevance 0.16 Pain Relevance 0.86
Furthermore, PPG pretreatment attenuated the induction of c-Fos in spinal laminae I-II following injection of 5% formalin.
Negative_regulation (attenuated) of Positive_regulation (induction) of c-Fos in spinal
3) Confidence 0.57 Published 2008 Journal Neuroscience Section Abstract Doc Link 18248901 Disease Relevance 0.80 Pain Relevance 0.18
Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference.
Negative_regulation (Suppression) of Positive_regulation (induction) of c-fos in nucleus accumbens associated with nucleus accumbens and morphine
4) Confidence 0.57 Published 2000 Journal Eur. J. Neurosci. Section Title Doc Link 10998122 Disease Relevance 0.09 Pain Relevance 0.83
A combination of peripheral acting cholinergic antagonists (chlorisondamine plus methylatropine) prevented the MTZ-induction of adrenal c-fos and PPenk mRNA without significant alterations in the MTZ-induction of hippocampal c-fos mRNA or convulsions.
Negative_regulation (prevented) of Positive_regulation (induction) of c-fos associated with convulsion and antagonist
5) Confidence 0.57 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255173 Disease Relevance 0.18 Pain Relevance 0.33
Treatment with LY274614, a competitive NMDA-receptor antagonist, blocked MTZ-induced convulsions and the MTZ-induction of c-fos and PPenk mRNAs in the hippocampus, and PPenk mRNA in the adrenal.
Negative_regulation (blocked) of Positive_regulation (induction) of c-fos in hippocampus associated with convulsion, antagonist and hippocampus
6) Confidence 0.57 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255173 Disease Relevance 0.17 Pain Relevance 0.30
Thus diclofenac pretreatment partially prevented the insult-induced increase in total and regional neuronal c-fos-LI.
Negative_regulation (prevented) of Positive_regulation (increase) of c-fos in neuronal associated with diclofenac
7) Confidence 0.57 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10781468 Disease Relevance 0.44 Pain Relevance 0.57
Drugs that suppressed bladder reflexes did not reduce c-fos induced by distension, indicating that voiding reflexes do not contribute to c-fos expression.
Neg (not) Negative_regulation (reduce) of Neg (not) Positive_regulation (induced) of c-fos in bladder associated with overactive bladder
8) Confidence 0.57 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8368386 Disease Relevance 0.67 Pain Relevance 0
Clonidine attenuated the increases in c-fos in the mNTS and cRVLM and c-jun gene expression in the mNTS and rRVLM caused by NP-evoked hypotension and also reduced the basal expression of c-jun mRNA in the mNTS and rRVLM.
Negative_regulation (attenuated) of Positive_regulation (increases) of c-fos associated with hypotension and clonidine
9) Confidence 0.57 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677633 Disease Relevance 0.17 Pain Relevance 0.71
This induction of c-Fos is reduced by administration of the N-methyl-D-aspartate receptor antagonist dizocilpine maleate.
Negative_regulation (reduced) of Positive_regulation (induction) of c-Fos associated with antagonist and nmda receptor
10) Confidence 0.57 Published 1999 Journal Neuroscience Section Abstract Doc Link 10501478 Disease Relevance 0 Pain Relevance 0.68
The activation of c-fos by magnetic stimulation was inhibited by the sodium-channel blocker tetrodotoxin (TTX) (10 microM).
Negative_regulation (inhibited) of Positive_regulation (activation) of c-fos associated with tetrodotoxin
11) Confidence 0.57 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11585578 Disease Relevance 0 Pain Relevance 0.52
Suppression of glucocorticoids decreased the induction of Fos proteins in response to a direct agonist of dopamine D(1) receptors (SKF 82958, 1.5 mg/kg, i.p.), but not the release of dopamine induced by morphine (2 mg/kg, s.c.) or the density of the limiting enzyme of dopamine synthesis, tyrosine hydroxylase.
Negative_regulation (decreased) of Positive_regulation (induction) of Fos associated with dopamine, agonist and morphine
12) Confidence 0.57 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11207816 Disease Relevance 0 Pain Relevance 0.57
MK-801 completely inhibited morphine-induced c-Fos in intact females but only caused partial inhibition in intact males; castrated males showed complete inhibition, which was reversed by testosterone, but gonadal steroids had no effect on this response in females.
Negative_regulation (inhibited) of Positive_regulation (induced) of c-Fos in gonadal associated with morphine
13) Confidence 0.57 Published 2002 Journal J. Appl. Physiol. Section Abstract Doc Link 11796656 Disease Relevance 0 Pain Relevance 0.70
Surprisingly, in many regions c-Fos induction by morphine was reduced or blocked by naloxone, even though these subjects had also experienced the effects of morphine for 30 min prior to antagonist administration.
Negative_regulation (reduced) of Positive_regulation (induction) of c-Fos associated with antagonist, narcan and morphine
14) Confidence 0.57 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17631915 Disease Relevance 0.67 Pain Relevance 1.70
The present data show that morphine suppresses the induction of c-fos.
Negative_regulation (suppresses) of Positive_regulation (induction) of c-fos associated with morphine
15) Confidence 0.57 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2110636 Disease Relevance 0 Pain Relevance 0.75
Surprisingly, in many regions c-Fos induction by morphine was reduced or blocked by naloxone, even though these subjects had also experienced the effects of morphine for 30 min prior to antagonist administration.
Negative_regulation (blocked) of Positive_regulation (induction) of c-Fos associated with antagonist, narcan and morphine
16) Confidence 0.57 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17631915 Disease Relevance 0.68 Pain Relevance 1.70
Second, the kappa receptor agonist spiradoline (1-10 mg/kg) reduced c-fos and zif 268 induction by SKF-39393 (2.5 mg/kg) preferentially in ventral parts of the dopamine-depleted striatum, which contain higher levels of kappa receptor mRNA and binding.
Negative_regulation (reduced) of Positive_regulation (induction) of c-fos in striatum associated with dopamine and agonist
17) Confidence 0.57 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8978468 Disease Relevance 0 Pain Relevance 0.77
Together, these results suggest that the restricted regional pattern of cocaine-induced c-fos expression is related, in part, to the basal level of dynorphin expression, and that cocaine treatment elevates dynorphin expression in striatal regions with a strong c-fos response, thereby limiting subsequent c-fos induction by cocaine.
Negative_regulation (limiting) of Positive_regulation (induction) of c-fos associated with dynorphin and cocaine
18) Confidence 0.57 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 7504719 Disease Relevance 0 Pain Relevance 0.89
The stress-induced c-fos induction was markedly decreased by a moderate (10 mg/kg) dose of morphine.
Negative_regulation (decreased) of Positive_regulation (induction) of c-fos associated with stress and morphine
19) Confidence 0.57 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12225868 Disease Relevance 0.66 Pain Relevance 0.77
Adrenal medullary grafts suppress c-fos induction in spinal neurons of arthritic rats.
Negative_regulation (suppress) of Positive_regulation (induction) of c-fos in spinal associated with arthritis
20) Confidence 0.57 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 7566645 Disease Relevance 0.44 Pain Relevance 0.40

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