INT667

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Context Info
Confidence 0.58
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 38
Total Number 38
Disease Relevance 18.11
Pain Relevance 18.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh2) signal transducer activity (Hrh2)
Anatomy Link Frequency
Plasma 1
muscle 1
corpus striatum 1
brain 1
trachea 1
Hrh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 90 100.00 Very High Very High Very High
Bioavailability 5 100.00 Very High Very High Very High
peptic ulcer disease 11 99.96 Very High Very High Very High
Angina 8 99.86 Very High Very High Very High
Analgesic 6 99.80 Very High Very High Very High
cINOD 144 99.62 Very High Very High Very High
lidocaine 22 99.20 Very High Very High Very High
Clonidine 19 99.04 Very High Very High Very High
Morphine 12 99.00 Very High Very High Very High
antinociception 10 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Renal Failure 4 100.00 Very High Very High Very High
Ulcers 113 99.96 Very High Very High Very High
Angina 8 99.86 Very High Very High Very High
Duodenal Ulcer 12 99.82 Very High Very High Very High
Vomiting 20 99.80 Very High Very High Very High
Disease 18 99.44 Very High Very High Very High
Dementia 1 99.32 Very High Very High Very High
Hypotension 1 99.28 Very High Very High Very High
Gastroesophageal Reflux Disease 2 99.04 Very High Very High Very High
Injury 28 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike clonidine, guanfacine does not inhibit dopamine turnover in the corpus striatum of the rat and its hypotensive effect is not inhibited by central H2-receptor blockade.
Negative_regulation (blockade) of H2-receptor in corpus striatum associated with dopamine, hypotension and clonidine
1) Confidence 0.58 Published 1982 Journal Clin Exp Hypertens A Section Abstract Doc Link 6280899 Disease Relevance 0.16 Pain Relevance 0.45
Cimetidine, unlike other H2 antagonists, potentiated MOR antinociception, potentiated opioid FSIA and increased brain MOR levels, actions that are not likely to be due to blockade of H2-receptors.
Negative_regulation (blockade) of H2-receptor in brain associated with antinociception, antagonist, opioid and morphine
2) Confidence 0.57 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2547933 Disease Relevance 0.14 Pain Relevance 1.94
H2-receptor blockade for the treatment of peptic ulcer disease has been with us for over a decade and has led to a dramatic decrease in the number of operations being performed for chronic ulcer disease.
Negative_regulation (blockade) of H2-receptor associated with peptic ulcer disease, ulcers and disease
3) Confidence 0.52 Published 1988 Journal Aust N Z J Surg Section Abstract Doc Link 2908172 Disease Relevance 0.62 Pain Relevance 0.17
The compound 48/80 response was partly inhibited by histamine H1 and H2 receptor blockade in the urinary bladder and in the duodenum, but not in the trachea, the oesophagus, the ureter and the paw skin.
Negative_regulation (blockade) of H2 receptor in trachea
4) Confidence 0.44 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6083460 Disease Relevance 0 Pain Relevance 0.31
Histamine-2 receptor blocking agents Cimetidine or Ranitidine in combination with metaclopramide, which enhances LES tone, facilitate management of induction and emergence in the traumatized patient.
Negative_regulation (blocking) of Histamine-2 receptor
5) Confidence 0.42 Published 1989 Journal Mil Med Section Abstract Doc Link 2573864 Disease Relevance 0.09 Pain Relevance 0.10
All of these observations are consistent with the idea that the effects of the H2-receptor antagonists showed in the present investigation are independent of H2-receptor blockade.
Negative_regulation (blockade) of H2-receptor associated with antagonist
6) Confidence 0.42 Published 1981 Journal Farmaco Sci Section Abstract Doc Link 6112158 Disease Relevance 0 Pain Relevance 0.30
[Effect of H2 histamine receptor blocking agents on the isolated lower esophageal sphincter (LES) of the rat].
Negative_regulation (blocking) of H2 histamine receptor in esophageal sphincter
7) Confidence 0.42 Published 1981 Journal Farmaco Sci Section Title Doc Link 6112158 Disease Relevance 0 Pain Relevance 0.16
[Long-term prevention with H2 receptor antagonists.
Negative_regulation (prevention) of H2 receptor associated with antagonist
8) Confidence 0.41 Published 1991 Journal Versicherungsmedizin Section Title Doc Link 1686689 Disease Relevance 0.78 Pain Relevance 0.22
Lafutidine is a new type of antiulcer drug, possessing both an antisecretory effect, exerted via a blockade of the histamine H2 receptor, and gastroprotective activity, mediated by capsaicin-sensitive afferent nerves (CSN).
Negative_regulation (blockade) of histamine H2 receptor in CSN associated with qutenza
9) Confidence 0.40 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12498288 Disease Relevance 0 Pain Relevance 0.29
H2-receptor antagonists have, however, greatly reduced the morbidity and the time off work due to peptic ulcer disease.
Negative_regulation (reduced) of H2-receptor associated with peptic ulcer disease, antagonist and disease
10) Confidence 0.39 Published 1987 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 2908766 Disease Relevance 0.79 Pain Relevance 0.50
The absence of ranitidine effects on the disposition of lidocaine, a high-extraction, high-clearance drug, suggests that H2-receptor blockade may not decrease hepatic blood flow, and that cimetidine impairs drug elimination only by inhibition of hepatic microsomal enzymes.
Negative_regulation (blockade) of H2-receptor in blood associated with lidocaine
11) Confidence 0.39 Published 1985 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 3987178 Disease Relevance 0 Pain Relevance 0.60
Intravenous cimetidine administered q8h offers a safe and cost-effective approach to H2-receptor blockade and reduction of gastric acid secretion in patients who are temporarily unable to take oral medication.
Negative_regulation (blockade) of H2-receptor
12) Confidence 0.39 Published 1990 Journal Ala Med Section Abstract Doc Link 2281832 Disease Relevance 0.85 Pain Relevance 0.21
At 4 weeks, symptom resolution has been specifically examined in six comparative trials; in three of these, omeprazole was superior to the H2-receptor antagonist, and in the other three was at least as good as the H2-receptor antagonist.
Negative_regulation (antagonist) of H2-receptor in superior associated with antagonist
13) Confidence 0.39 Published 1994 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 8047824 Disease Relevance 1.37 Pain Relevance 0.56
The clinical use of such system would enable a selection of patients to receive the effective prophylactic measure of pretreatment with H1 plus H2-receptor antagonists.
Negative_regulation (antagonists) of H2-receptor associated with antagonist
14) Confidence 0.39 Published 1988 Journal Agents Actions Section Abstract Doc Link 2456003 Disease Relevance 0 Pain Relevance 0.05
In patients who present with haematemesis and melaena, there is little evidence to show that H2-receptor antagonists reduce rates of transfusion or surgical intervention, or decrease mortality.
Negative_regulation (decrease) of H2-receptor associated with antagonist
15) Confidence 0.39 Published 1994 Journal Drugs Section Abstract Doc Link 7521828 Disease Relevance 0.57 Pain Relevance 0.28
After six months of H2-receptor blockade, 12 of 15 group II patients were asymptomatic, whereas a significantly smaller percentage (five of 18) of patients with abnormal esophageal motility responded to esophageal dilation or treatment with calcium channel blockade, H2-receptor antagonist, and/or prokinetic agents (P less than 0.01).
Negative_regulation (blockade) of H2-receptor associated with antagonist and calcium channel
16) Confidence 0.38 Published 1992 Journal Dig. Dis. Sci. Section Abstract Doc Link 1563306 Disease Relevance 0.72 Pain Relevance 0.31
This effect appears to be related to the chemical structure of the individual H2-receptor antagonists and is not attributable to histamine H2-receptor blockade.
Negative_regulation (blockade) of H2-receptor associated with antagonist
17) Confidence 0.37 Published 1986 Journal Med Toxicol Section Abstract Doc Link 2878343 Disease Relevance 0.19 Pain Relevance 0.34
68 patients with chronic peptic ulcer took part in a double-blind trial in which 32 received the histamine H2-receptor antagonist cimetidine, (400 mg twice daily) and 36 received a placebo, for a year. 6 of those on cimetidine had an endoscopically proven recurrent ulcer within a mean of 7 months, while 30 of those on placebo had one after a mean of 4 months (P less than 0.0005). 1 patient on cimetidine had two recurrences compared with 12 patients on placebo (P less than 0.0005).
Negative_regulation (received) of H2-receptor associated with antagonist, ulcers and recurrence
18) Confidence 0.34 Published 1978 Journal Lancet Section Abstract Doc Link 75439 Disease Relevance 0.36 Pain Relevance 0.05
After a committee review of available data, H2-receptor antagonists were considered therapeutically equivalent.
Negative_regulation (equivalent) of H2-receptor associated with antagonist
19) Confidence 0.32 Published 1990 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1978846 Disease Relevance 0.43 Pain Relevance 0.35
If any of the test results suggest gastroesophageal reflux, a trial of therapy for this indication, eg, a histamine2 receptor blocker, should be initiated.
Negative_regulation (blocker) of histamine2 receptor associated with gastroesophageal reflux disease
20) Confidence 0.29 Published 1988 Journal Postgrad Med Section Abstract Doc Link 3357867 Disease Relevance 0.75 Pain Relevance 0.37

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