INT667
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Unlike clonidine, guanfacine does not inhibit dopamine turnover in the corpus striatum of the rat and its hypotensive effect is not inhibited by central H2-receptor blockade. | |||||||||||||||
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Cimetidine, unlike other H2 antagonists, potentiated MOR antinociception, potentiated opioid FSIA and increased brain MOR levels, actions that are not likely to be due to blockade of H2-receptors. | |||||||||||||||
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H2-receptor blockade for the treatment of peptic ulcer disease has been with us for over a decade and has led to a dramatic decrease in the number of operations being performed for chronic ulcer disease. | |||||||||||||||
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The compound 48/80 response was partly inhibited by histamine H1 and H2 receptor blockade in the urinary bladder and in the duodenum, but not in the trachea, the oesophagus, the ureter and the paw skin. | |||||||||||||||
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Histamine-2 receptor blocking agents Cimetidine or Ranitidine in combination with metaclopramide, which enhances LES tone, facilitate management of induction and emergence in the traumatized patient. | |||||||||||||||
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All of these observations are consistent with the idea that the effects of the H2-receptor antagonists showed in the present investigation are independent of H2-receptor blockade. | |||||||||||||||
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[Effect of H2 histamine receptor blocking agents on the isolated lower esophageal sphincter (LES) of the rat]. | |||||||||||||||
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[Long-term prevention with H2 receptor antagonists. | |||||||||||||||
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Lafutidine is a new type of antiulcer drug, possessing both an antisecretory effect, exerted via a blockade of the histamine H2 receptor, and gastroprotective activity, mediated by capsaicin-sensitive afferent nerves (CSN). | |||||||||||||||
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H2-receptor antagonists have, however, greatly reduced the morbidity and the time off work due to peptic ulcer disease. | |||||||||||||||
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The absence of ranitidine effects on the disposition of lidocaine, a high-extraction, high-clearance drug, suggests that H2-receptor blockade may not decrease hepatic blood flow, and that cimetidine impairs drug elimination only by inhibition of hepatic microsomal enzymes. | |||||||||||||||
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Intravenous cimetidine administered q8h offers a safe and cost-effective approach to H2-receptor blockade and reduction of gastric acid secretion in patients who are temporarily unable to take oral medication. | |||||||||||||||
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At 4 weeks, symptom resolution has been specifically examined in six comparative trials; in three of these, omeprazole was superior to the H2-receptor antagonist, and in the other three was at least as good as the H2-receptor antagonist. | |||||||||||||||
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The clinical use of such system would enable a selection of patients to receive the effective prophylactic measure of pretreatment with H1 plus H2-receptor antagonists. | |||||||||||||||
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In patients who present with haematemesis and melaena, there is little evidence to show that H2-receptor antagonists reduce rates of transfusion or surgical intervention, or decrease mortality. | |||||||||||||||
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After six months of H2-receptor blockade, 12 of 15 group II patients were asymptomatic, whereas a significantly smaller percentage (five of 18) of patients with abnormal esophageal motility responded to esophageal dilation or treatment with calcium channel blockade, H2-receptor antagonist, and/or prokinetic agents (P less than 0.01). | |||||||||||||||
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This effect appears to be related to the chemical structure of the individual H2-receptor antagonists and is not attributable to histamine H2-receptor blockade. | |||||||||||||||
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68 patients with chronic peptic ulcer took part in a double-blind trial in which 32 received the histamine H2-receptor antagonist cimetidine, (400 mg twice daily) and 36 received a placebo, for a year. 6 of those on cimetidine had an endoscopically proven recurrent ulcer within a mean of 7 months, while 30 of those on placebo had one after a mean of 4 months (P less than 0.0005). 1 patient on cimetidine had two recurrences compared with 12 patients on placebo (P less than 0.0005). | |||||||||||||||
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After a committee review of available data, H2-receptor antagonists were considered therapeutically equivalent. | |||||||||||||||
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If any of the test results suggest gastroesophageal reflux, a trial of therapy for this indication, eg, a histamine2 receptor blocker, should be initiated. | |||||||||||||||
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General Comments
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