INT66708

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Context Info
Confidence 0.38
First Reported 1996
Last Reported 1999
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 3.10
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NISCH) plasma membrane (NISCH) cytoplasm (NISCH)
NISCH (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 9 98.28 Very High Very High Very High
antidepressant 3 98.00 Very High Very High Very High
Clonidine 7 88.56 High High
addiction 3 82.88 Quite High
Opioid 3 82.48 Quite High
noradrenaline 3 78.52 Quite High
agonist 1 71.04 Quite High
antagonist 2 69.88 Quite High
Desipramine 1 44.44 Quite Low
Disease Link Frequency Relevance Heat
Disease 9 100.00 Very High Very High Very High
Suicidal Behaviour 6 99.60 Very High Very High Very High
Depression 9 98.28 Very High Very High Very High
Glioma 6 91.52 High High
Neurodegenerative Disease 3 84.00 Quite High
Opiate Addiction 3 82.88 Quite High
Brain Disease 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, moxonidine acts via presynaptic alpha 2-autoreceptors, leaving the presynaptic imidazoline receptor unaffected.
Neg (unaffected) Negative_regulation (unaffected) of imidazoline receptor
1) Confidence 0.38 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8938671 Disease Relevance 0 Pain Relevance 0.58
The 29/30-kD IR protein (putative I2B-IR) is downregulated (19%) in suicide victims in parallel with a reduction (40%) in the density of I2B-IR ([3H]idazoxan binding).
Negative_regulation (downregulated) of I2B-IR associated with suicidal behaviour
2) Confidence 0.19 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 1.03 Pain Relevance 0.30
The density of I2B-IR is increased in Alzheimer's disease (63%) and decreased in Huntington's disease (56%).
Negative_regulation (decreased) of I2B-IR associated with disease
3) Confidence 0.14 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 1.04 Pain Relevance 0.25
The 29/30-kD IR protein (putative I2B-IR) is downregulated (19%) in suicide victims in parallel with a reduction (40%) in the density of I2B-IR ([3H]idazoxan binding).
Negative_regulation (reduction) of I2B-IR associated with suicidal behaviour
4) Confidence 0.14 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415944 Disease Relevance 1.03 Pain Relevance 0.30

General Comments

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