INT66709

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Context Info
Confidence 0.71
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 5.65
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
chondrocytes 1
cartilage 1
PGE2 1
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 87 99.92 Very High Very High Very High
Clonidine 11 94.44 High High
metalloproteinase 23 92.60 High High
anesthesia 27 92.20 High High
cINOD 1 80.00 Quite High
Inflammation 41 66.08 Quite High
Angina 2 47.60 Quite Low
imagery 18 39.88 Quite Low
COX2 5 25.00 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 88 99.92 Very High Very High Very High
Alveolar Rhabdomyosarcoma 40 99.76 Very High Very High Very High
Anaemia 6 98.72 Very High Very High Very High
Overweight 13 98.36 Very High Very High Very High
Hyperplasia 2 97.20 Very High Very High Very High
Growth Problems 16 96.20 Very High Very High Very High
Osteoporosis 41 93.88 High High
Renal Failure 7 92.40 High High
Disease 13 92.16 High High
Cancer 25 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative reverse transcription polymerase chain reaction (QRT-PCR) performed on de novo atherectomy specimens identified mRNA for IGF-I, IGF-I receptor, IGFBP-1, IGFBP-2, IGFBP-4, IGFBP-5 levels and detected mRNA for IGFBP-3.
Transcription (detected) of IGF-I
1) Confidence 0.71 Published 1996 Journal Regul. Pept. Section Abstract Doc Link 8988513 Disease Relevance 0 Pain Relevance 0
Under basal condition, OA Ob expressed similar IGF-1 mRNA to normal Ob; however, PGE2 stimulated IGF-1 mRNA expression more in OA than normal Ob.
Transcription (expressed) of IGF-1 mRNA in PGE2 associated with osteoarthritis
2) Confidence 0.69 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.00 Pain Relevance 0.62
Quantitative reverse transcription polymerase chain reaction (QRT-PCR) performed on de novo atherectomy specimens identified mRNA for IGF-I, IGF-I receptor, IGFBP-1, IGFBP-2, IGFBP-4, IGFBP-5 levels and detected mRNA for IGFBP-3.
Transcription (detected) of IGF-I
3) Confidence 0.68 Published 1996 Journal Regul. Pept. Section Abstract Doc Link 8988513 Disease Relevance 0 Pain Relevance 0
In the IGF-I generation test, after GH injection, the thalassaemic children had significantly lower IGF-I and IGFBP-3 levels 86.7 +/- 11.2 ng/ml and 2.05 +/- 0.51 mg/l respectively) than those in the CSS group (226 +/- 45.4 ng/ml and 2.8 +/- 0.43 mg/l respectively).
Transcription (had) of IGF-I associated with growth problems
4) Confidence 0.64 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.61 Pain Relevance 0.07
In the IGF-I generation test, after GH injection, the thalassaemic children had significantly lower IGF-I and IGFBP-3 levels 86.7 +/- 11.2 ng/ml and 2.05 +/- 0.51 mg/l respectively) than those in the CSS group (226 +/- 45.4 ng/ml and 2.8 +/- 0.43 mg/l respectively).
Transcription (had) of IGF-I associated with growth problems
5) Confidence 0.64 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.62 Pain Relevance 0.07
Within the other groups there were no significant alterations over time after surgery in any variable, with the exception of IGF-1 in group D which decreased postoperatively from 153 to116 ?
Neg (exception) Transcription (exception) of IGF-1
6) Confidence 0.58 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0 Pain Relevance 0.06
g/ml) was tested for its ability to maintain optimal IGF-1 transcription and translation in cartilage explants and cultured chondrocytes.


Transcription (transcription) of IGF-1 in cartilage
7) Confidence 0.49 Published 2007 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1971260 Disease Relevance 0.30 Pain Relevance 0.12
Similarly, this present study progrado was able to maintain normal IGF-1 protein and mRNA levels despite the presence of IL-1?
Transcription (levels) of IGF-1
8) Confidence 0.49 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.18 Pain Relevance 0.08
On the other hand, IGF-I concentrations after rhEPO therapy (32.05 +/- 5.52 nmol/l) were not significantly different from those found prior to starting therapy (38.13 +/- 8.44 nmol/l).
Transcription (concentrations) of IGF-I
9) Confidence 0.38 Published 1996 Journal Nephron Section Abstract Doc Link 8938679 Disease Relevance 0.50 Pain Relevance 0.38
It has also been reported that the PAX/FKHR fusion protein characteristic of alveolar RMS may induce transcription of IGF-I and other growth factors, further suggesting autocrine mechanisms of cellular proliferation [18, 19].
Transcription (transcription) of IGF-I associated with hyperplasia and alveolar rhabdomyosarcoma
10) Confidence 0.34 Published 2010 Journal Pediatr Radiol Section Body Doc Link PMC2895865 Disease Relevance 1.16 Pain Relevance 0
The adipokine at 100 ng/ml increased the mRNA level of IGF-1 in chondrocytes obtained from normal or overweight patients (Figure 2).
Transcription (level) of IGF-1 in chondrocytes associated with overweight
11) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.72 Pain Relevance 0.07
Specifically, PTH and estradiol have been shown to enhance IGF-1 transcription in rats [5,37].
Transcription (transcription) of IGF-1
12) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.51 Pain Relevance 0
IGF-I mRNA and GHR mRNA levels were related to the expression of a housekeeping gene (cyclophilin).
Transcription (levels) of IGF-I mRNA
13) Confidence 0.05 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9589657 Disease Relevance 0.07 Pain Relevance 0.18

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