INT66710

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Context Info
Confidence 0.32
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.42
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
nerve 2
dorsal horn 2
hippocampus 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 18 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
narcan 7 99.98 Very High Very High Very High
Enkephalin 3 99.86 Very High Very High Very High
Analgesic 1 99.86 Very High Very High Very High
c fibre 6 99.84 Very High Very High Very High
Hippocampus 2 99.80 Very High Very High Very High
amygdala 2 99.38 Very High Very High Very High
Dorsal horn 16 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 3 99.98 Very High Very High Very High
Nervous System Injury 10 99.74 Very High Very High Very High
Death 2 67.76 Quite High
Pain 8 36.52 Quite Low
Neuropathic Pain 12 29.52 Quite Low
Nociception 3 26.60 Quite Low
Injury 13 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anoxia blocks the presynaptic control of GABA release at inhibitory terminals in the rat hippocampus.
Negative_regulation (blocks) of Regulation (control) of GABA in hippocampus associated with gaba, analgesic and hippocampus
1) Confidence 0.32 Published 1996 Journal Neuroscience Section Title Doc Link 8938736 Disease Relevance 0.25 Pain Relevance 0.63
Naloxone blocked the effect of systemic morphine administration on nigral dynorphin B and GABA release, already at a dose of 0.2 mg/kg s.c.
Negative_regulation (blocked) of Regulation (effect) of GABA associated with gaba, dynorphin, narcan and morphine
2) Confidence 0.31 Published 1996 Journal Brain Res. Section Abstract Doc Link 8963665 Disease Relevance 0 Pain Relevance 2.12
However, following nerve injury we report a reduction in GABA(A)-receptor control of C-fibre responses, in particular in relation to post-discharge responses.
Negative_regulation (reduction) of Regulation (control) of GABA in nerve associated with c fibre, gaba and nervous system injury
3) Confidence 0.18 Published 2003 Journal Brain Res. Section Abstract Doc Link 12543472 Disease Relevance 0.10 Pain Relevance 0.99
potentiates the action of GABA in amygdala [33] and hippocampus [34] yet reduces sIPSC amplitude and GABA sensitivity in the superficial dorsal horn [14].
Negative_regulation (reduces) of Regulation (sensitivity) of GABA in dorsal horn associated with gaba, dorsal horn, hippocampus and amygdala
4) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2625335 Disease Relevance 0.07 Pain Relevance 0.49

General Comments

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