INT66713

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Context Info
Confidence 0.22
First Reported 1996
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (BDKRB1, KNG1) extracellular space (KNG1) extracellular region (KNG1)
endoplasmic reticulum (BDKRB1) signal transducer activity (BDKRB1)
Anatomy Link Frequency
Hyp3 1
BDKRB1 (Homo sapiens)
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 15 100.00 Very High Very High Very High
B1 receptor 11 100.00 Very High Very High Very High
b2 receptor 3 98.24 Very High Very High Very High
antagonist 4 97.60 Very High Very High Very High
IPN 1 86.76 High High
Inflammation 2 85.88 High High
dorsal root ganglion 2 75.00 Quite High
Pain 2 69.16 Quite High
nociceptor 1 67.72 Quite High
agonist 1 39.76 Quite Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 1 86.76 High High
INFLAMMATION 2 85.88 High High
Ganglion Cysts 2 75.00 Quite High
Pain 2 69.16 Quite High
Injury 2 35.84 Quite Low
Sepsis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound 11 (2-[(2R)-1-[(3,4-dichlorophenyl) sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]-N-[2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl]acetamide) is a high-affinity nonpeptide antagonist for the human B1R, but it is potent at the rabbit B1R as well: its Ki value for the inhibition of [3H]Lys-des-Arg9-BK (bradykinin) binding to a novel myc-labeled rabbit B1R expressed in COS-1 is 22 pM.
B1R Binding (binding) of bradykinin associated with b1 receptor, antagonist and bradykinin
1) Confidence 0.22 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277582 Disease Relevance 0.17 Pain Relevance 0.58
Blocking the bradykinin binding at the B1 receptor with (Des-Arg10)-Lys-bradykinin and at the B2 receptor with D-Arg(Hyp3-Thi5.8-D-Phe7)-bradykinin, respectively, revealed that in 0.75-day-old cultures no or only a very small amount of B1 receptors are present.
B1 receptor Binding (binding) of bradykinin in Hyp3 associated with b1 receptor, b2 receptor and bradykinin
2) Confidence 0.11 Published 1996 Journal Neuroscience Section Abstract Doc Link 8938754 Disease Relevance 0.22 Pain Relevance 0.96

General Comments

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