INT66716

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.31
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (BDKRB1) plasma membrane (BDKRB1) signal transducer activity (BDKRB1)
Anatomy Link Frequency
Hyp3 1
BDKRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 32 100.00 Very High Very High Very High
B1 receptor 7 100.00 Very High Very High Very High
antagonist 7 100.00 Very High Very High Very High
vincristine 1 99.84 Very High Very High Very High
agonist 4 99.10 Very High Very High Very High
b2 receptor 5 98.80 Very High Very High Very High
Hyperalgesia 5 98.24 Very High Very High Very High
Pain 4 97.68 Very High Very High Very High
Analgesic 1 95.44 Very High Very High Very High
cINOD 1 86.88 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 98.24 Very High Very High Very High
Pain 4 97.68 Very High Very High Very High
Neuropathic Pain 4 96.80 Very High Very High Very High
INFLAMMATION 1 86.48 High High
Diabetes Mellitus 3 78.44 Quite High
Ganglion Cysts 2 75.00 Quite High
Injury 2 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In other rings, indomethacin (30, 100 micromol/l) or NS-398 (10, 30 micromol/l) produced a significant rightward shift of the CRC to BK, selective BK B2 agonist, and its pKbs were similar to the values to inhibit BK B1 receptor responses, suggesting that COX-2 pathway also is involved in BK B2 receptor responses.
Negative_regulation (inhibit) of BK B1 receptor associated with b1 receptor, b2 receptor and agonist
1) Confidence 0.48 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11534854 Disease Relevance 0 Pain Relevance 0.40
[Des-Arg10,Leu9]kallidin (DALKD) is a selective B1 receptor antagonist, and NPC17731 is a selective B2 receptor antagonist.
Negative_regulation (antagonist) of B1 receptor associated with antagonist, b1 receptor and b2 receptor
2) Confidence 0.29 Published 1998 Journal Life Sci. Section Abstract Doc Link 9651119 Disease Relevance 0.17 Pain Relevance 0.59
Blocking the bradykinin binding at the B1 receptor with (Des-Arg10)-Lys-bradykinin and at the B2 receptor with D-Arg(Hyp3-Thi5.8-D-Phe7)-bradykinin, respectively, revealed that in 0.75-day-old cultures no or only a very small amount of B1 receptors are present.
Negative_regulation (Blocking) of B1 receptor in Hyp3 associated with b1 receptor, b2 receptor and bradykinin
3) Confidence 0.16 Published 1996 Journal Neuroscience Section Abstract Doc Link 8938754 Disease Relevance 0.22 Pain Relevance 0.96
Bradykinin receptor antagonists and cyclooxygenase inhibitors in vincristine- and streptozotocin-induced hyperalgesia.
Negative_regulation (inhibitors) of Bradykinin receptor associated with vincristine, hyperalgesia, antagonist and bradykinin
4) Confidence 0.01 Published 2009 Journal Pharmacol Rep Section Title Doc Link 19815945 Disease Relevance 0.92 Pain Relevance 1.04

General Comments

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