INT66718

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Context Info
Confidence 0.64
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 9.89
Pain Relevance 11.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BDKRB2) plasma membrane (BDKRB2) signal transducer activity (BDKRB2)
Anatomy Link Frequency
skin 2
monocytes 1
vessels 1
umbilical veins 1
sympathetic 1
BDKRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 592 100.00 Very High Very High Very High
b2 receptor 56 100.00 Very High Very High Very High
acular 63 99.68 Very High Very High Very High
B1 receptor 61 99.68 Very High Very High Very High
Kinase C 61 99.36 Very High Very High Very High
Pain 115 99.30 Very High Very High Very High
agonist 75 99.24 Very High Very High Very High
nociceptor 16 96.92 Very High Very High Very High
Inflammation 91 95.68 Very High Very High Very High
cytokine 17 93.64 High High
Disease Link Frequency Relevance Heat
Osteoporosis 2 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 66 99.36 Very High Very High Very High
Pre-eclampsia 132 99.26 Very High Very High Very High
Pain 121 99.00 Very High Very High Very High
Injury 104 98.96 Very High Very High Very High
Diabetes Mellitus 72 98.92 Very High Very High Very High
Placenta Accreta 4 98.50 Very High Very High Very High
INFLAMMATION 97 95.68 Very High Very High Very High
Pathologic Processes 8 93.24 High High
Nociception 13 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bradykinin, a vasoactive peptide, plays a crucial role in many cardiovascular processes via activation of the bradykinin subtype 2 receptor (B2R).
Positive_regulation (activation) of B2R associated with bradykinin
1) Confidence 0.64 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16740128 Disease Relevance 0.18 Pain Relevance 0.30
Bradykinin, a vasoactive peptide, plays a crucial role in many cardiovascular processes via activation of the bradykinin subtype 2 receptor (B2R).
Positive_regulation (activation) of bradykinin subtype 2 receptor associated with bradykinin
2) Confidence 0.64 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16740128 Disease Relevance 0.18 Pain Relevance 0.29
The nonapeptide bradykinin (BK) is a Janus-faced hormone, which exerts pathophysiological as well as pronounced beneficial physiological effects, mainly by stimulation of BK B(2) receptors.
Positive_regulation (stimulation) of BK associated with bradykinin
3) Confidence 0.45 Published 2003 Journal Expert Opin Investig Drugs Section Abstract Doc Link 12720488 Disease Relevance 0.38 Pain Relevance 0.51
Either exogenous administration of BK or locally increased BK concentrations as a consequence of the inhibition of its metabolic breakdown by angiotensin-converting enzyme inhibitors, reveal the significant contribution of BK in powerful cardioprotective mechanisms.
Positive_regulation (increased) of BK associated with bradykinin
4) Confidence 0.45 Published 2003 Journal Expert Opin Investig Drugs Section Abstract Doc Link 12720488 Disease Relevance 0.44 Pain Relevance 0.60
Sensitization to bradykinin B1 and B2 receptor activation in UV-B irradiated human skin.
Positive_regulation (activation) of B2 receptor in skin associated with pain, b2 receptor and bradykinin
5) Confidence 0.44 Published 2004 Journal Pain Section Title Doc Link 15275768 Disease Relevance 0.64 Pain Relevance 1.04
Similarly, BDKRB2 was 2-fold upregulated in the placebo treated group (p < 0.0001; paired t-test; n = 15) and 1.9-fold upregulated in the ketorolac treatment group (p < 0.0001; paired t-test; n = 15).
Positive_regulation (upregulated) of BDKRB2 associated with acular
6) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.71 Pain Relevance 0.99
Both BDKRB1 and BDKRB2 were significantly upregulated 3 hours following tissue injury in both the placebo and ketorolac treatment group (Table 1).
Positive_regulation (upregulated) of BDKRB2 associated with injury and acular
7) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.50 Pain Relevance 0.77
Similarly, BDKRB2 was 2-fold upregulated in the placebo treated group (p < 0.0001; paired t-test; n = 15) and 1.9-fold upregulated in the ketorolac treatment group (p < 0.0001; paired t-test; n = 15).
Positive_regulation (upregulated) of BDKRB2 associated with acular
8) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.58 Pain Relevance 0.84
Activation of B2R is preferentially coupled to G proteins of the G?
Positive_regulation (Activation) of B2R
9) Confidence 0.38 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.40 Pain Relevance 0.29
In normal skin, both B1 and B2 receptor activation dose-dependently evoked pain, vasodilatation and protein extravasation.
Positive_regulation (activation) of B2 receptor in skin associated with pain, b2 receptor and increased venous pressure under development
10) Confidence 0.32 Published 2004 Journal Pain Section Abstract Doc Link 15275768 Disease Relevance 0.75 Pain Relevance 1.01
The B1R mediates the actions of Lys-des-Arg9- bradykinin whereas B2R is activated by the main kinin, bradykinin [19,20].
Positive_regulation (activated) of B2R associated with bradykinin
11) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.40 Pain Relevance 0.32
B2R activation also activates PKC, phosphatase A2, phospholipase C, and phosphoinositide 3-kinase (PI3K), and stimulates production of nitric oxide [19,20].
Positive_regulation (activation) of B2R associated with kinase c
12) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.47 Pain Relevance 0.31
In conclusion, BK has mitogenic actions in cultured human epithelial breast cells; the activation of PKC-delta through B2 receptor acts in concert with ERK and PI3K pathways to induce cell proliferation.
Positive_regulation (activation) of B2 receptor associated with b2 receptor and bradykinin
13) Confidence 0.26 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0 Pain Relevance 0.33
These findings suggest that BK increased both IL-6 and PGE(2) synthesis in osteoblastic cells via B2R and that PLC, IP(3)-induced [Ca(2+)]i, MEK, and MAPKs were involved in the signal transduction in these cells.
Positive_regulation (increased) of B2R associated with osteoporosis and bradykinin
14) Confidence 0.25 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.31 Pain Relevance 0.54
Since activation of B2R leads to release of intracellular calcium [19,20], we first determined the concentration that evoked the maximum [Ca2+]i response in U-87 cells.
Positive_regulation (activation) of B2R
15) Confidence 0.25 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.19
By activating the B2R, kinins induce vasodilation, increase vascular permeability and antiplatelet aggregation, both directly or by stimulating the synthesis of nitric oxide (NO) and PGI2.
Positive_regulation (activating) of B2R associated with increased venous pressure under development
16) Confidence 0.24 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.33 Pain Relevance 0.21
In preeclampsia, the only observed difference is an increased B2R signal in the extravillous trophoblast.
Positive_regulation (increased) of B2R associated with pre-eclampsia
17) Confidence 0.24 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.24 Pain Relevance 0.09
B2R mRNA levels were higher in CD34pos CPC than in CD14+ monocytes, with no difference between H and T1D groups (Fig.
Positive_regulation (higher) of B2R in monocytes associated with diabetes mellitus
18) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.70 Pain Relevance 0.09
In 1.75-day-old cultures, the marked increase in the proportion of cells with positive bradykinin binding is due to a de novo expression of the B1 receptor subtype and an up-regulation of the B2 receptor subtype.
Positive_regulation (up-regulation) of B2 receptor associated with b1 receptor, b2 receptor and bradykinin
19) Confidence 0.19 Published 1996 Journal Neuroscience Section Abstract Doc Link 8938754 Disease Relevance 0.25 Pain Relevance 0.89
In placenta accreta, a condition of exaggerated invasiveness, the expression of kallikrein is increased in syncytiotrophoblast, and that of the B2R in the fetal endothelium and in extravillous trophoblast; in contrast to normal pregnancy, kallikrein is expressed in extravillous trophoblast.
Positive_regulation (increased) of B2R in syncytiotrophoblast associated with placenta accreta
20) Confidence 0.18 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.31 Pain Relevance 0.03

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