INT66719

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Context Info
Confidence 0.27
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (BDKRB1) plasma membrane (BDKRB1) signal transducer activity (BDKRB1)
Anatomy Link Frequency
fibroblasts 1
BDKRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
B1 receptor 2 100.00 Very High Very High Very High
bradykinin 89 99.42 Very High Very High Very High
b2 receptor 4 98.52 Very High Very High Very High
dorsal root ganglion 2 75.00 Quite High
Pain 2 54.16 Quite High
nociceptor 1 52.72 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 193 99.24 Very High Very High Very High
Ganglion Cysts 2 75.00 Quite High
Injury 5 65.20 Quite High
Pain 2 54.16 Quite High
Stress 102 50.00 Quite Low
Death 1 17.40 Low Low
Apoptosis 24 5.00 Very Low Very Low Very Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Down Syndrome 16 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 1.75-day-old cultures, the marked increase in the proportion of cells with positive bradykinin binding is due to a de novo expression of the B1 receptor subtype and an up-regulation of the B2 receptor subtype.
Transcription (expression) of B1 receptor associated with b1 receptor, b2 receptor and bradykinin
1) Confidence 0.27 Published 1996 Journal Neuroscience Section Abstract Doc Link 8938754 Disease Relevance 0.25 Pain Relevance 0.92
Given the increased length and hence strength of aberrant BKB2R signal transduction in the PS-1 M146L AD fibroblasts, this cell line was chosen for further study of putative downstream signaling steps beyond the BKB2R itself, focusing on the MAP kinase pathway.
Transcription (transduction) of BKB2R in fibroblasts associated with disease
2) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.63 Pain Relevance 0.09

General Comments

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