INT66725

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 8.70
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Rars) nucleolus (Rars) nucleus (Rars)
ligase activity (Rars) cytoplasm (Rars)
Anatomy Link Frequency
Respiratory 1
Rars (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 5 99.80 Very High Very High Very High
agonist 9 93.84 High High
substance P 1 88.32 High High
Inflammation 3 86.32 High High
tolerance 1 84.72 Quite High
dexamethasone 48 81.16 Quite High
alcohol 22 77.92 Quite High
corticosteroid 11 76.72 Quite High
headache 2 60.48 Quite High
abdominal pain 3 29.56 Quite Low
Disease Link Frequency Relevance Heat
Gastroesophageal Reflux Disease 246 100.00 Very High Very High Very High
Rheumatoid Arthritis 62 99.96 Very High Very High Very High
Occupational Lung Diseases 141 99.88 Very High Very High Very High
Infection 2 99.88 Very High Very High Very High
Obesity 24 98.68 Very High Very High Very High
Cough 23 98.22 Very High Very High Very High
Asthma 165 94.72 High High
Hypersensitivity 2 93.44 High High
Acid Reflux 9 89.68 High High
Cancer 6 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several major issues have been discussed in these presentations, including the pharmacologic, physiologic and neurochemical characteristics of the cough receptors; the effect of phenotypic switch of the rapidly adapting receptors (RARs) during chronic airway infection; the interaction between RARs and C-fiber afferents both at the receptor level and in the centrally mediated reflex pathway; and the cellular mechanisms and ion channel species involved in the hypersensitivity of the cough receptors.
RARs Binding (interaction) of associated with c fibre, hypersensitivity, cough and infection
1) Confidence 0.48 Published 2002 Journal Pulm Pharmacol Ther Section Abstract Doc Link 12099767 Disease Relevance 0.77 Pain Relevance 0.10
This is the first report of an association of RARS with atypical symptoms of GORD.
RARS Binding (association) of associated with gastroesophageal reflux disease
2) Confidence 0.40 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2954896 Disease Relevance 1.42 Pain Relevance 0.08
The strength and pattern of cough depends on the sites of the airway that are stimulated and the local and central reflex interactions of the RARs and C fiber receptors.
RARs Binding (interactions) of associated with c fibre and cough
3) Confidence 0.35 Published 1996 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 8939181 Disease Relevance 0.61 Pain Relevance 0.44
In addition to a higher prevalence of GORD symptoms, asthmatics also associate GORD symptoms with respiratory symptoms, the so-called Reflux Associated Respiratory Symptoms (RARS).
RARS Binding (associate) of in Respiratory associated with gastroesophageal reflux disease and occupational lung diseases
4) Confidence 0.35 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2954896 Disease Relevance 2.38 Pain Relevance 0
We have now shown that the prevalence of RARS is associated not only with typical symptoms but also with atypical symptoms of GORD.
RARS Binding (associated) of associated with gastroesophageal reflux disease
5) Confidence 0.30 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2954896 Disease Relevance 1.51 Pain Relevance 0.04
All-trans retinoic acid (RA) binds only RARs and induces its own metabolism.
RARs Binding (binds) of associated with rheumatoid arthritis
6) Confidence 0.20 Published 1996 Journal Clin. Cancer Res. Section Abstract Doc Link 9816192 Disease Relevance 0.60 Pain Relevance 0.19
ATRA binds RAR with high affinity but does not bind to RXR, whereas 9-cis-RA, an isomer of ATRA, is a ligand that binds and transactivates both RARs and RXRs.
RARs Binding (binds) of associated with rheumatoid arthritis
7) Confidence 0.12 Published 1998 Journal Clin. Cancer Res. Section Abstract Doc Link 9626460 Disease Relevance 1.06 Pain Relevance 0.06
Retinoids signal through their receptors, RARs and RXRs.
RARs Binding (receptors) of
8) Confidence 0.09 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.35 Pain Relevance 0.10

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