INT66751

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 48
Total Number 50
Disease Relevance 26.00
Pain Relevance 19.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
neutrophils 6
liver 6
macrophages 4
Kupffer cell 4
hepatocyte 4
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 120 100.00 Very High Very High Very High
cytokine 47 100.00 Very High Very High Very High
aspirin 39 100.00 Very High Very High Very High
Cannabinoid 9 99.98 Very High Very High Very High
cINOD 20 99.76 Very High Very High Very High
Paracetamol 39 99.12 Very High Very High Very High
anesthesia 38 99.08 Very High Very High Very High
Endogenous opioid 5 99.00 Very High Very High Very High
diclofenac 2 98.96 Very High Very High Very High
narcan 10 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 109 100.00 Very High Very High Very High
Necrosis 63 100.00 Very High Very High Very High
Cancer 52 100.00 Very High Very High Very High
Pressure And Volume Under Development 11 99.96 Very High Very High Very High
Endotoxemia 2 99.90 Very High Very High Very High
Burns 8 99.36 Very High Very High Very High
Disease 16 98.92 Very High Very High Very High
Injury 51 98.64 Very High Very High Very High
Arthritis 7 98.04 Very High Very High Very High
Immunization 1 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data also indicate an impairment of TNF-alpha release in Kupffer cell cultures after treatment with nontoxic, as well as with toxic, acetaminophen concentrations.
Negative_regulation (impairment) of Localization (release) of TNF-alpha in Kupffer cell associated with paracetamol
1) Confidence 0.59 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.21 Pain Relevance 0.50
We observed a dose-dependent decrease of TNF-alpha mRNA in the hepatocytes, and of TNF-alpha release into the medium of hepatocyte cultures.
Negative_regulation (decrease) of Localization (release) of TNF-alpha in hepatocyte
2) Confidence 0.59 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.23 Pain Relevance 0.49
Urethan anesthesia protects rats against lethal endotoxemia and reduces TNF-alpha release.
Negative_regulation (reduces) of Localization (release) of TNF-alpha associated with endotoxemia and anesthesia
3) Confidence 0.58 Published 1996 Journal J. Appl. Physiol. Section Title Doc Link 8941558 Disease Relevance 0.61 Pain Relevance 0.14
We conclude that urethan or its metabolites protect against LPS, in part, by reducing TNF-alpha release and speculate that this may be mediated by alpha 2-adrenoceptors.
Negative_regulation (reducing) of Localization (release) of TNF-alpha
4) Confidence 0.58 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8941558 Disease Relevance 0.60 Pain Relevance 0.11
AIM: To investigate: (i) molecular events that regulate TNFalpha secretion in response to aspirin in vivo and in vitro; (ii) whether TNFalpha secretion inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal damage; and (iii) whether TNFalpha exerts a direct cytotoxic effect on gastric epithelial cells.
Spec (whether) Negative_regulation (prevent) of Localization (release) of TNFalpha in epithelial cells
5) Confidence 0.58 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.09 Pain Relevance 0
Incubating the macrophages in a Ca2+ free medium inhibited TNFalpha secretion.
Negative_regulation (inhibited) of Localization (secretion) of TNFalpha in macrophages
6) Confidence 0.58 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.06 Pain Relevance 0
AIM: To investigate: (i) molecular events that regulate TNFalpha secretion in response to aspirin in vivo and in vitro; (ii) whether TNFalpha secretion inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal damage; and (iii) whether TNFalpha exerts a direct cytotoxic effect on gastric epithelial cells.
Spec (whether) Negative_regulation (prevent) of Localization (secretion) of TNFalpha in epithelial cells
7) Confidence 0.58 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.09 Pain Relevance 0
BACKGROUND: Although previous studies indicate that prevention of tumour necrosis factor alpha (TNFalpha) release protects against NSAID-induced gastric mucosal injury, intracellular pathways by which aspirin causes TNFalpha release are unknown.
Negative_regulation (prevention) of Localization (release) of TNFalpha associated with aspirin, necrosis, cancer, injury and cinod
8) Confidence 0.58 Published 1998 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 9845404 Disease Relevance 0.37 Pain Relevance 0.23
In this regard, it has been reported that ent-kaurene diterpenes inhibit the expression of inducible nitric oxide synthase (iNOS) and the release of tumor necrosis factor-alpha (TNF-?).
Negative_regulation (inhibit) of Localization (release) of TNF associated with necrosis and cancer
9) Confidence 0.57 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959212 Disease Relevance 0.78 Pain Relevance 0.32
Phentolamine, an alpha-receptor blocker, decreased the LPS-induced TNF-alpha release by 57% at 30 min.
Negative_regulation (decreased) of Localization (release) of TNF-alpha
10) Confidence 0.57 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11752888 Disease Relevance 0 Pain Relevance 0
The positive control betamethasone inhibited TNF-alpha release almost completely at all concentrations tested.
Negative_regulation (inhibited) of Localization (release) of TNF-alpha
11) Confidence 0.54 Published 2006 Journal Exp. Eye Res. Section Abstract Doc Link 16965772 Disease Relevance 0.38 Pain Relevance 0.34
By contrast, the dopaminergic drug GLC756 compared to controls in the concentration range 1-30 microM significantly inhibited TNF-alpha release from activated rat mast cells in a concentration-dependent manner.
Negative_regulation (inhibited) of Localization (release) of TNF-alpha in mast cells
12) Confidence 0.54 Published 2006 Journal Exp. Eye Res. Section Abstract Doc Link 16965772 Disease Relevance 0.40 Pain Relevance 0.33
SB203580 inhibited p38 MAPK activity, reduced myocyte secretion of TNF-alpha, and prevented burn-mediated cardiac deficits.
Negative_regulation (reduced) of Localization (secretion) of TNF-alpha in myocyte associated with burns
13) Confidence 0.53 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11299196 Disease Relevance 1.08 Pain Relevance 0.20
Release of tumor necrosis factor alpha and nitric oxide was suppressed by norepinephrine, phenylephrine, dobutamine and terbutaline.
Negative_regulation (suppressed) of Localization (Release) of tumor necrosis factor alpha associated with necrosis and cancer
14) Confidence 0.45 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423672 Disease Relevance 0.55 Pain Relevance 0.55
Also, the release of tumor necrosis factor-alpha by hepatocytes was reduced after exposure to high acetaminophen doses (40-50 mM).
Negative_regulation (reduced) of Localization (release) of tumor necrosis factor-alpha in hepatocytes associated with necrosis, paracetamol and cancer
15) Confidence 0.43 Published 1997 Journal Toxicology Section Abstract Doc Link 9230444 Disease Relevance 0.28 Pain Relevance 0.40
The results suggest that inhibition of TNF-alpha expression and release in the liver is a consequence of acetaminophen exposure.
Negative_regulation (inhibition) of Localization (release) of TNF-alpha in liver associated with paracetamol
16) Confidence 0.43 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.19 Pain Relevance 0.52
Impairment of TNF-alpha expression and secretion in primary rat liver cell cultures by acetaminophen treatment.
Negative_regulation (Impairment) of Localization (secretion) of TNF-alpha in liver associated with paracetamol
17) Confidence 0.43 Published 1999 Journal Toxicology Section Title Doc Link 10378475 Disease Relevance 0.29 Pain Relevance 0.44
Similarly, intraportal infusion of NE in vivo or in isolated livers increased TNF-alpha synthesis and release which was inhibited by co-infusion of yohimbine.
Negative_regulation (inhibited) of Localization (release) of TNF-alpha in livers
18) Confidence 0.43 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.18 Pain Relevance 0.27
TACE inhibitors prevent TNFalpha release and protect against TNFalpha-mediated disease.
Negative_regulation (prevent) of Localization (release) of TNFalpha associated with disease
19) Confidence 0.43 Published 1998 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 9845404 Disease Relevance 0.44 Pain Relevance 0.22
TNFalpha processing enzyme inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal injury in rats.
Negative_regulation (prevent) of Localization (release) of TNFalpha associated with aspirin and injury
20) Confidence 0.43 Published 1998 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 9845404 Disease Relevance 0.38 Pain Relevance 0.28

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