INT66752

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Context Info
Confidence 0.68
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 10.86
Pain Relevance 7.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
sciatic nerve 2
cerebrum 2
brain 2
epithelial cells 2
peritoneal macrophages 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 69 100.00 Very High Very High Very High
Inflammation 46 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Sciatic nerve 22 99.98 Very High Very High Very High
Neuritis 10 99.92 Very High Very High Very High
Thalamus 3 99.64 Very High Very High Very High
ischemia 14 99.58 Very High Very High Very High
Eae 50 99.56 Very High Very High Very High
noradrenaline 11 99.18 Very High Very High Very High
Hippocampus 16 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 56 100.00 Very High Very High Very High
Necrosis 15 100.00 Very High Very High Very High
Cancer 15 100.00 Very High Very High Very High
Sepsis 31 99.98 Very High Very High Very High
Brain Injury 4 99.98 Very High Very High Very High
Experimental Autoimmune Neuritis 10 99.92 Very High Very High Very High
Cv Unclassified Under Development 15 99.58 Very High Very High Very High
Injury 80 99.56 Very High Very High Very High
Ulcers 17 99.08 Very High Very High Very High
Arthritis 6 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: (i) Aspirin directly stimulates TNFalpha gene transcription; (ii) TACE inhibitors protect against aspirin-induced gastric mucosal injury; and (iii) TNFalpha exerts a direct cytotoxic effect on gastric epithelial cells.


Positive_regulation (stimulates) of Transcription (transcription) of TNFalpha in epithelial cells
1) Confidence 0.68 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0 Pain Relevance 0
Inhibitory effect of amygdalin on lipopolysaccharide-inducible TNF-alpha and IL-1beta mRNA expression and carrageenan-induced rat arthritis.
Positive_regulation (inducible) of Transcription (expression) of TNF-alpha associated with arthritis
2) Confidence 0.50 Published 2008 Journal J. Microbiol. Biotechnol. Section Title Doc Link 18955812 Disease Relevance 0.77 Pain Relevance 0.49
Surprisingly, unilateral CCI of the sciatic nerve induced significant bilateral changes in the level of TNF-?
Positive_regulation (induced) of Transcription (level) of TNF in sciatic nerve associated with eae and sciatic nerve
3) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.61 Pain Relevance 0.42
Additionally, mRNA and protein (IL-1beta and TNF-alpha) levels of the pro-inflammatory cytokines IL-1alpha, IL-1beta and TNF-alpha were elevated in COR rats compared with INT and ADX rats.
Positive_regulation (elevated) of Transcription (levels) of TNF-alpha associated with inflammation and cytokine
4) Confidence 0.48 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12562515 Disease Relevance 0.85 Pain Relevance 0.47
Additionally, mRNA and protein (IL-1beta and TNF-alpha) levels of the pro-inflammatory cytokines IL-1alpha, IL-1beta and TNF-alpha were elevated in COR rats compared with INT and ADX rats.
Positive_regulation (elevated) of Transcription (levels) of TNF-alpha associated with inflammation and cytokine
5) Confidence 0.48 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12562515 Disease Relevance 0.85 Pain Relevance 0.47
Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS.
Positive_regulation (induces) of Transcription (expression) of tumor necrosis factor-alpha in brain associated with necrosis, cancer and brain injury
6) Confidence 0.47 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8965649 Disease Relevance 0.98 Pain Relevance 0.25
Urethan neither directly bound LPS by Limulus assay nor inhibited LPS-stimulated TNF-alpha mRNA expression in cultured mouse peritoneal macrophages, but TNF-alpha mRNA expression was suppressed by serum from a urethan-treated rat.
Positive_regulation (stimulated) of Transcription (expression) of TNF-alpha in peritoneal macrophages
7) Confidence 0.46 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8941558 Disease Relevance 0.70 Pain Relevance 0.11
Simultaneously, we found that NA also markedly inhibited the ATP-induced increase in the expression of tumor necrosis factor (TNF)-alpha mRNA through beta-adrenergic pathways.
Positive_regulation (increase) of Transcription (expression) of TNF associated with necrosis, cancer and noradrenaline
8) Confidence 0.45 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0.20 Pain Relevance 0.50
release following an increase in the TNF-a mRNA expression by activating mitogen-activated protein kinases (MAPKs) [80, 81].
Positive_regulation (increase) of Transcription (expression) of TNF-a
9) Confidence 0.45 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 0.92 Pain Relevance 0.80
release following an increase in the TNF-a mRNA expression by activating mitogen-activated protein kinases (MAPKs) [80, 81].
Positive_regulation (activating) of Transcription (expression) of TNF-a
10) Confidence 0.45 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 0.91 Pain Relevance 0.80
At 16 h, TNF-alpha expression mRNA increased.
Positive_regulation (increased) of Transcription (expression) of TNF-alpha
11) Confidence 0.45 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18584332 Disease Relevance 0.27 Pain Relevance 0.77
The IL-1beta, TNFalpha, and COX-1 mRNA were detected in intact and ulcerated gastric mucosa, whereas COX-2 mRNA were upregulated only in ulcerated mucosa with peak observed at day 3 after ulcer induction.
Positive_regulation (upregulated) of Transcription (detected) of TNFalpha associated with ulcers
12) Confidence 0.38 Published 2001 Journal Microsc. Res. Tech. Section Abstract Doc Link 11376495 Disease Relevance 0.95 Pain Relevance 0.18
The ghrelin-enhanced acceleration of healing of ischemia/perfusion induced lesions was accompanied by enhanced expression of mRNA for HIF-1alpha and by diminution of the ischemia/reperfusion induced increase in mRNA expression for TNF-alpha.
Positive_regulation (increase) of Transcription (expression) of TNF-alpha associated with ischemia
13) Confidence 0.30 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16581065 Disease Relevance 0.83 Pain Relevance 0.50
Increased mRNA expression for IFN-gamma and TNF-alpha was registered correlating with the peak of clinical signs of EAN, and high levels of mRNA expression for IL-4, IL-10, and TGF-beta were associated with EAN recovery.
Positive_regulation (Increased) of Transcription (expression) of TNF-alpha associated with neuritis
14) Confidence 0.22 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.08 Pain Relevance 1.03
Sepsis enhanced the transcription of several pro- and anti-inflammatory cytokines and chemokines including tumor necrosis factor alpha, interleukin-1 beta, transforming growth factor beta, and monocot chemoattractant protein 1 in the cerebrum.
Positive_regulation (enhanced) of Transcription (transcription) of tumor necrosis factor alpha in cerebrum associated with chemokine, necrosis, inflammation, cancer, sepsis and cytokine
15) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2553764 Disease Relevance 0.93 Pain Relevance 0.47

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