INT66753

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 45
Total Number 46
Disease Relevance 35.28
Pain Relevance 22.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
brain 4
microglia 4
neurons 4
lung 3
plasma 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 156 100.00 Very High Very High Very High
cytokine 105 100.00 Very High Very High Very High
Inflammatory mediators 51 100.00 Very High Very High Very High
allodynia 50 100.00 Very High Very High Very High
COX2 29 100.00 Very High Very High Very High
cva 21 100.00 Very High Very High Very High
Spinal cord 14 100.00 Very High Very High Very High
fibrosis 14 100.00 Very High Very High Very High
Calcitonin gene-related peptide 10 100.00 Very High Very High Very High
orphanin 13 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 235 100.00 Very High Very High Very High
Injury 88 100.00 Very High Very High Very High
Neuropathic Pain 83 100.00 Very High Very High Very High
Necrosis 49 100.00 Very High Very High Very High
Cancer 41 100.00 Very High Very High Very High
Nervous System Injury 19 100.00 Very High Very High Very High
Stress 18 100.00 Very High Very High Very High
Hemorrhage 14 100.00 Very High Very High Very High
Pressure And Volume Under Development 14 100.00 Very High Very High Very High
Cystic Fibrosis 10 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the increased cellular levels of TNF-alpha in Kupffer cells after in vivo administration of NE was also blocked by yohimbine.
Negative_regulation (blocked) of Positive_regulation (increased) of TNF-alpha in Kupffer cells
1) Confidence 0.59 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.18 Pain Relevance 0.26
The peak increase in tumor necrosis factor-alpha (TNF-alpha) 90 min after LPS administration was reduced 88% by urethan (2,060 +/- 316 vs. 16,934 +/- 847 pg/ml; P < 0.001).
Negative_regulation (reduced) of Positive_regulation (increase) of TNF-alpha associated with necrosis and cancer
2) Confidence 0.58 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8941558 Disease Relevance 0.79 Pain Relevance 0.12
Treatment with sirolimus resulted in antihyperalgesic and antiallodynic effects and prevented the increased spinal cord TNF-alpha level.
Negative_regulation (prevented) of Positive_regulation (increased) of TNF-alpha in spinal cord associated with antihyperalgesic, antiallodynic and spinal cord
3) Confidence 0.58 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20600616 Disease Relevance 1.06 Pain Relevance 1.37
Conversely, a prevention of the increase in TNF-alpha levels was observed only in rats treated with nimesulide or tramadol and paracetamol in combination.
Negative_regulation (prevention) of Positive_regulation (increase) of TNF-alpha
4) Confidence 0.58 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17377112 Disease Relevance 0.07 Pain Relevance 0
Intrathecal delivery of PDTC (8.2 ng in 10 microl volume), a nuclear factor-kappa B (NF-kappaB) inhibitor, 30 min before each rrTNF administration blocked mechanical allodynia completely and inhibited the upregulation of TNF-alpha-IR and TNFR1-IR substantially.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of TNF-alpha-IR associated with allodynia and intrathecal
5) Confidence 0.57 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17459378 Disease Relevance 0.23 Pain Relevance 0.50
The increase of endoneurial TNF-alpha during the first week after CCI was reduced after thalidomide treatment, as shown with immunohistochemistry and enzyme-linked-immunosorbent assay.
Negative_regulation (reduced) of Positive_regulation (increase) of TNF-alpha associated with nervous system injury
6) Confidence 0.52 Published 2000 Journal Pain Section Abstract Doc Link 11068114 Disease Relevance 1.00 Pain Relevance 0.68
Treatment with any one of the three sympatholytics abolished the upregulation of NGF and IL-6, while phentolamine and guanethedine also reversed the upregulation of TNF-alpha.
Negative_regulation (reversed) of Positive_regulation (upregulation) of TNF-alpha associated with nerve growth factor
7) Confidence 0.49 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12015213 Disease Relevance 0.95 Pain Relevance 0.98
Oxytocin treatment reversed the burn-induced elevations in MDA and MPO levels and reduced the gastric damage scores (p<0.001, p<0.01), while TNF-alpha levels, which were increased significantly at 48thh after injury (p<0.001), were abolished with OT treatment (p<0.001).
Negative_regulation (abolished) of Positive_regulation (increased) of TNF-alpha associated with burns, injury and urological neuroanatomy
8) Confidence 0.46 Published 2008 Journal Burns Section Abstract Doc Link 17826914 Disease Relevance 1.54 Pain Relevance 0.21
Inhibitory effect of amygdalin on lipopolysaccharide-inducible TNF-alpha and IL-1beta mRNA expression and carrageenan-induced rat arthritis.
Negative_regulation (effect) of Positive_regulation (inducible) of TNF-alpha associated with arthritis
9) Confidence 0.43 Published 2008 Journal J. Microbiol. Biotechnol. Section Title Doc Link 18955812 Disease Relevance 0.76 Pain Relevance 0.48
This increase of both TNF-alpha and nitrate levels induced by lipopolysaccharide was significantly reduced in lipopolysaccharide-rats pretreated with pentoxifylline.
Negative_regulation (reduced) of Positive_regulation (induced) of TNF-alpha
10) Confidence 0.43 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10408250 Disease Relevance 0.14 Pain Relevance 0.12
The peak increase in tumor necrosis factor-alpha (TNF-alpha) 90 min after LPS administration was reduced 88% by urethan (2,060 +/- 316 vs. 16,934 +/- 847 pg/ml; P < 0.001).
Negative_regulation (reduced) of Positive_regulation (increase) of tumor necrosis factor-alpha associated with necrosis and cancer
11) Confidence 0.42 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8941558 Disease Relevance 0.79 Pain Relevance 0.12
AIM: To investigate: (i) molecular events that regulate TNFalpha secretion in response to aspirin in vivo and in vitro; (ii) whether TNFalpha secretion inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal damage; and (iii) whether TNFalpha exerts a direct cytotoxic effect on gastric epithelial cells.
Spec (whether) Negative_regulation (prevent) of Spec (whether) Positive_regulation (aspirin-induced) of TNFalpha in epithelial cells
12) Confidence 0.42 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.09 Pain Relevance 0
Intrathecal delivery of SB203580, a p38 inhibitor, significantly inhibited the development of mechanical allodynia and the upregulation of COX2, iNOS and TNF-?.


Negative_regulation (inhibited) of Positive_regulation (upregulation) of TNF associated with allodynia, cox2 and intrathecal
13) Confidence 0.42 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2881061 Disease Relevance 1.39 Pain Relevance 0.90
The rats pretreated with S. polycystum showed considerable inhibition in the elevation of TNF-alpha compared to the rats intoxicated with acetaminophen.
Negative_regulation (inhibition) of Positive_regulation (elevation) of TNF-alpha
14) Confidence 0.41 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 16804966 Disease Relevance 0 Pain Relevance 0
This is consistent with our data showing that NS treated patients with poor outcome according to GOS score also exhibit the highest levels of TNF-?
Negative_regulation (exhibit) of Positive_regulation (levels) of TNF
15) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.06 Pain Relevance 0.15
Simultaneously, we found that NA also markedly inhibited the ATP-induced increase in the expression of tumor necrosis factor (TNF)-alpha mRNA through beta-adrenergic pathways.
Negative_regulation (inhibited) of Positive_regulation (increase) of TNF associated with necrosis, cancer and noradrenaline
16) Confidence 0.41 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0.20 Pain Relevance 0.50
This may be because salvia miltiorrhizae can effectively inhibit the release of endotoxin and thereby reduce the production of other inflammatory mediators such as TNF-?
Negative_regulation (reduce) of Positive_regulation (mediators) of TNF associated with inflammatory mediators
17) Confidence 0.41 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.40 Pain Relevance 0.27
In addition, NAC diminished the LPS-induced increases in nitrate/nitrite, MG, TNF-a and IL-1b. 5.
Negative_regulation (diminished) of Positive_regulation (increases) of TNF
18) Confidence 0.41 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16445696 Disease Relevance 0.60 Pain Relevance 0.06
Therefore, suppressing the production of inflammatory mediators, such as endotoxin, TNF-?
Negative_regulation (suppressing) of Positive_regulation (mediators) of TNF associated with inflammatory mediators
19) Confidence 0.41 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.06 Pain Relevance 0.41
However, central chemical sympathectomy attenuated the hemorrhage-induced increase in lung and spleen TNF-alpha, enhanced the IL-6 response in spleen and blunted the rise in circulating beta-endorphin levels.
Negative_regulation (attenuated) of Positive_regulation (increase) of TNF-alpha in lung associated with cva
20) Confidence 0.41 Published 1999 Journal Neuroimmunomodulation Section Abstract Doc Link 10213918 Disease Relevance 0.61 Pain Relevance 0.56

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