INT66754

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 8.43
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
lymph node 4
RAW 264 4
peritoneal macrophages 4
leukocyte 2
mast cell 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 8 99.70 Very High Very High Very High
cytokine 9 99.04 Very High Very High Very High
Inflammatory mediators 4 98.88 Very High Very High Very High
Neuritis 11 98.68 Very High Very High Very High
Arthritis 6 98.68 Very High Very High Very High
Hyperalgesia 4 94.56 High High
ischemia 77 94.44 High High
Analgesic 5 92.96 High High
Inflammation 30 92.48 High High
tolerance 4 92.40 High High
Disease Link Frequency Relevance Heat
Necrosis 9 100.00 Very High Very High Very High
Cancer 8 100.00 Very High Very High Very High
Immunization 3 99.70 Very High Very High Very High
INFLAMMATION 29 98.88 Very High Very High Very High
Experimental Autoimmune Neuritis 10 98.68 Very High Very High Very High
Arthritis 9 98.68 Very High Very High Very High
Adhesions 3 97.08 Very High Very High Very High
Reperfusion Injury 32 94.76 High High
Hyperalgesia 5 94.56 High High
Cv Unclassified Under Development 59 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One mM amygdalin significantly inhibited the expression of TNF-alpha and IL-1beta mRNAs in LPS-treated RAW 264.7 cells.
Negative_regulation (inhibited) of Transcription (expression) of TNF-alpha in RAW 264
1) Confidence 0.43 Published 2008 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18955812 Disease Relevance 0.77 Pain Relevance 0.45
Urethan neither directly bound LPS by Limulus assay nor inhibited LPS-stimulated TNF-alpha mRNA expression in cultured mouse peritoneal macrophages, but TNF-alpha mRNA expression was suppressed by serum from a urethan-treated rat.
Negative_regulation (suppressed) of Transcription (expression) of TNF-alpha in peritoneal macrophages
2) Confidence 0.43 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8941558 Disease Relevance 0.68 Pain Relevance 0.11
Urethan neither directly bound LPS by Limulus assay nor inhibited LPS-stimulated TNF-alpha mRNA expression in cultured mouse peritoneal macrophages, but TNF-alpha mRNA expression was suppressed by serum from a urethan-treated rat.
Negative_regulation (inhibited) of Transcription (expression) of TNF-alpha in peritoneal macrophages
3) Confidence 0.43 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8941558 Disease Relevance 0.70 Pain Relevance 0.11
Serum and local TNF-alpha levels were suppressed in treated animals whereas there were little changes in interleukin-1beta levels.
Negative_regulation (suppressed) of Transcription (levels) of TNF-alpha
4) Confidence 0.43 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10884526 Disease Relevance 1.20 Pain Relevance 0.77
Agents that prevent TNFalpha mRNA transcription, e.g. lisophylline, PGE2, interleukin-10 and 8-BrcAMP, or TACE inhibitors, e.g.
Negative_regulation (prevent) of Transcription (transcription) of TNFalpha
5) Confidence 0.43 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.05 Pain Relevance 0
Numbers of AChR-, MBP-, BPM-reactive Th1 type of cytokine interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha mRNA expression in lymph node cells were markedly suppressed, while transforming growth factor-beta (TGF-beta) mRNA expression was upregulated from nasally tolerized rats, suggesting an active suppression mechanism may act partly in the induction of tolerance.
Negative_regulation (suppressed) of Transcription (expression) of TNF in lymph node associated with necrosis, cancer, tolerance and cytokine
6) Confidence 0.42 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 1.10 Pain Relevance 0.48
Cromolyn Sodium (CS) is a mast cell membrane stabilizer, it can inhibit the mast cell de-granulation and releasing of histamine, TNF-?
Negative_regulation (inhibit) of Transcription (granulation) of TNF in mast cell
7) Confidence 0.41 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 1.00 Pain Relevance 0.23
STME reduced levels of tumor necrosis factor-alpha, both mRNA and its protein, and significantly decreased IL-1beta and IL-6 production.
Negative_regulation (reduced) of Transcription (levels) of tumor necrosis factor-alpha associated with necrosis and cancer
8) Confidence 0.33 Published 2008 Journal Pharmacology Section Abstract Doc Link 18818510 Disease Relevance 0.45 Pain Relevance 0.24
VPA (300 mg/kg, intraperitoneally) administration to EAN rats once daily immediately following immunization significantly suppressed mRNA levels of interferon-gamma, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-4, IL-6 and IL-17 in the lymph nodes of EAN rats.
Negative_regulation (suppressed) of Transcription (levels) of tumor necrosis factor-alpha in lymph nodes associated with necrosis, cancer, immunization and neuritis
9) Confidence 0.32 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18953683 Disease Relevance 1.36 Pain Relevance 0.99
A reduced TNF-alpha and ICAM-1 mRNA expression seen after IP may account for the inhibitory effects of IP on leukocyte adhesion and ameloriated microcirculatory disturbance after IR in vivo [23-26].
Negative_regulation (reduced) of Transcription (expression) of TNF-alpha in leukocyte associated with adhesions
10) Confidence 0.31 Published 2006 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1636295 Disease Relevance 0.59 Pain Relevance 0.10
It was observed that GABA significantly inhibited the mRNA expression of iNOS, IL-1beta, and TNF-alpha, in LPS-stimulated RAW 264.7 cells.
Negative_regulation (inhibited) of Transcription (expression) of TNF-alpha in RAW 264 associated with gaba
11) Confidence 0.13 Published 2007 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18156782 Disease Relevance 0.53 Pain Relevance 0.44

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