INT66757

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 8.14
Pain Relevance 4.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
nucleus 6
lung 4
Hook 2
bone marrow 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 1 99.56 Very High Very High Very High
aspirin 47 99.54 Very High Very High Very High
chemokine 1 99.08 Very High Very High Very High
cytokine 16 98.80 Very High Very High Very High
Inflammation 87 98.34 Very High Very High Very High
Antinociceptive 3 98.12 Very High Very High Very High
Inflammatory response 3 91.12 High High
agonist 1 87.04 High High
antagonist 1 85.92 High High
Glutamate 1 83.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 95 99.56 Very High Very High Very High
Apoptosis 1 98.84 Very High Very High Very High
Necrosis 5 98.46 Very High Very High Very High
Cancer 6 98.28 Very High Very High Very High
Stress 5 95.36 Very High Very High Very High
Toxicity 6 93.60 High High
Rhinitis 2 92.28 High High
Nociception 4 85.76 High High
Infection 5 84.96 Quite High
Asthma 8 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phytoceuticals such as Korean red ginseng, green tea, red wine, flavonoids, broccoli sprouts, garlic, probiotics and flavonoids are known to inhibit H. pylori colonization, decrease gastric inflammation by inhibiting cytokine and chemokine release, and repress precancerous changes by inhibiting nuclear factor-kappa B DNA binding, inducing profuse levels of apoptosis and inhibiting mutagenesis.
Negative_regulation (inhibiting) of nuclear factor-kappa B Binding (binding) of associated with chemokine, inflammation, apoptosis and cytokine
1) Confidence 0.57 Published 2008 Journal J Dig Dis Section Abstract Doc Link 18956590 Disease Relevance 1.17 Pain Relevance 0.28
Furthermore, Cardiospermum halicacabum L. ethanol extract inhibited the TNF-alpha induced DNA binding activity of NF-kappaB, which was associated with decreased p65 protein level in the nucleus in Jurkat cells.
Negative_regulation (inhibited) of NF-kappaB Binding (binding) of in nucleus
2) Confidence 0.52 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19393729 Disease Relevance 0.06 Pain Relevance 0
Cryptolepine has been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor-kappa B following inflammatory stimuli in vitro.
Negative_regulation (inhibit) of Nuclear Factor-kappa B Binding (binding) of associated with inflammatory stimuli
3) Confidence 0.43 Published 2009 Journal Phytother Res Section Abstract Doc Link 19288476 Disease Relevance 0.57 Pain Relevance 0.21
Nuclear extracts of purified, aspirin-treated DC revealed a decreased NF-kappaB DNA-binding activity, whereas Ab supershift analysis indicated that aspirin targeted primarily NF-kappaB p50.
Negative_regulation (decreased) of NF-kappaB Binding (binding) of associated with aspirin
4) Confidence 0.42 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.08 Pain Relevance 0.42
Nuclear extracts of purified, aspirin-treated DC revealed a decreased NF-kappaB DNA-binding activity, whereas Ab supershift analysis indicated that aspirin targeted primarily NF-kappaB p50.
Negative_regulation (decreased) of NF-kappaB Binding (activity) of associated with aspirin
5) Confidence 0.42 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.08 Pain Relevance 0.42
In fact, NF-kappaB binding activity decreased after exposure to NAPQI and DNCB.
Negative_regulation (decreased) of NF-kappaB Binding (binding) of
6) Confidence 0.41 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.53 Pain Relevance 0.12
At the same concentrations, they inhibited NF-kappaB binding to DNA in nuclear extracts.
Negative_regulation (inhibited) of NF-kappaB Binding (binding) of
7) Confidence 0.39 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11377405 Disease Relevance 0.24 Pain Relevance 0.39
Taken together, our data indicate that the anti-inflammatory and antinociceptive properties of siegeskaurolic acid may be due to iNOS, COX-2 and TNF-alpha inhibition via the down-regulation of NF-kappaB binding activity.
Negative_regulation (down-regulation) of NF-kappaB Binding (binding) of associated with inflammation and antinociceptive
8) Confidence 0.34 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17207792 Disease Relevance 0.44 Pain Relevance 0.22
In addition, binding of signal transducer and activator of transcription 6 (STAT6) and nuclear factor kappa B (NF-kappa B) oligonucleotides to lung nuclear proteins was significantly reduced in mice treated with inhaled APC.
Negative_regulation (reduced) of NF-kappa B Binding (binding) of in lung
9) Confidence 0.31 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 0.91 Pain Relevance 0.49
In addition, binding of signal transducer and activator of transcription 6 (STAT6) and nuclear factor kappa B (NF-kappa B) oligonucleotides to lung nuclear proteins was significantly reduced in mice treated with inhaled APC.
Negative_regulation (reduced) of nuclear factor kappa B Binding (binding) of in lung
10) Confidence 0.31 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 0.91 Pain Relevance 0.49
Furthermore, MEXS inhibited nuclear factor kappa B (NF-kappaB) DNA binding activity and the translocation of NF-kappaB to the nucleus by blocking the degradation of inhibitor of kappa B-alpha (IkappaB-alpha).
Negative_regulation (inhibited) of NF-kappaB Binding (binding) of in nucleus
11) Confidence 0.27 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.64 Pain Relevance 0.19
Furthermore, MEXS inhibited nuclear factor kappa B (NF-kappaB) DNA binding activity and the translocation of NF-kappaB to the nucleus by blocking the degradation of inhibitor of kappa B-alpha (IkappaB-alpha).
Negative_regulation (inhibited) of nuclear factor kappa B Binding (activity) of in nucleus
12) Confidence 0.27 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.65 Pain Relevance 0.19
Culture of bone marrow stromal cells in VP-16 resulted in reduced nuclear RelA (p65), a modest increase in nuclear NF-kappaB1 (p50), and reduced NF-kappaB binding to its DNA consensus sequence.
Negative_regulation (reduced) of NF-kappaB Binding (binding) of in bone marrow
13) Confidence 0.27 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.07 Pain Relevance 0
Arvanil also prevents tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activation by direct inhibition of IkappaBalpha degradation, NF-kappaB binding to DNA, and NF-kappaB-dependent transcription.
Negative_regulation (inhibition) of NF-kappaB Binding (binding) of associated with necrosis and cancer
14) Confidence 0.16 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16394182 Disease Relevance 0.42 Pain Relevance 0.31
In vitro, rofecoxib dose dependently inhibited DNA binding capacity of NF-kappaB at doses of 10 to 100 microM, whereas the binding activity of AP-1 was considerably increased at 100 microM.
Negative_regulation (inhibited) of NF-kappaB Binding (capacity) of
15) Confidence 0.12 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12604692 Disease Relevance 0.55 Pain Relevance 0.35
[20] It is also known that several diterpenoids isolated from the Chinese herb Isodon rubescens are potent inhibitors of NF-kappa B transcriptional activity which subsequently target iNOS and cycloxygenase-2 (COX-2), with the latter being less sensitive to diterpenoids.[21] Other diterpenoids isolated from Chinese herbal remedy (Tripterygium wilfordii Hook.f.) inhibit the interleukin-1?
Negative_regulation (inhibitors) of NF-kappa B Binding (activity) of in Hook
16) Confidence 0.12 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959212 Disease Relevance 0.61 Pain Relevance 0.24
Furthermore, by electrophoretic mobility shift analysis we demonstrate reduced DNA binding of the nuclear factor kappaB, an essential component of the IL-1beta-dependent upregulation of sPLA2 gene transcription, after treatment of the cells with aspirin.
Negative_regulation (reduced) of nuclear factor kappaB Binding (binding) of associated with aspirin
17) Confidence 0.02 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8941724 Disease Relevance 0.20 Pain Relevance 0.60

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