INT66758

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Context Info
Confidence 0.48
First Reported 1995
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 97
Total Number 99
Disease Relevance 50.65
Pain Relevance 23.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
nucleus 6
lung 5
liver 2
plasma 1
muscles 1
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 605 100.00 Very High Very High Very High
cytokine 320 100.00 Very High Very High Very High
aspirin 69 100.00 Very High Very High Very High
Substantia nigra 37 100.00 Very High Very High Very High
antagonist 29 100.00 Very High Very High Very High
cINOD 28 100.00 Very High Very High Very High
Hyperalgesia 10 99.90 Very High Very High Very High
Paracetamol 44 99.88 Very High Very High Very High
Inflammatory stimuli 12 99.56 Very High Very High Very High
qutenza 17 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 668 100.00 Very High Very High Very High
Disease 323 100.00 Very High Very High Very High
Injury 59 100.00 Very High Very High Very High
Congenital Anomalies 2 100.00 Very High Very High Very High
Phosphate Metabolism Disorders 6 99.92 Very High Very High Very High
Hyperalgesia 10 99.90 Very High Very High Very High
Schizophrenia 57 99.84 Very High Very High Very High
Pancreatitis 10 99.84 Very High Very High Very High
Hemophilus Infection 801 99.74 Very High Very High Very High
Frailty 27 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cryptolepine has been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor-kappa B following inflammatory stimuli in vitro.
Nuclear Factor-kappa B Binding (binding) of associated with inflammatory stimuli
1) Confidence 0.48 Published 2009 Journal Phytother Res Section Abstract Doc Link 19288476 Disease Relevance 0.57 Pain Relevance 0.21
Phytoceuticals such as Korean red ginseng, green tea, red wine, flavonoids, broccoli sprouts, garlic, probiotics and flavonoids are known to inhibit H. pylori colonization, decrease gastric inflammation by inhibiting cytokine and chemokine release, and repress precancerous changes by inhibiting nuclear factor-kappa B DNA binding, inducing profuse levels of apoptosis and inhibiting mutagenesis.
nuclear factor-kappa B Binding (binding) of associated with chemokine, inflammation, apoptosis and cytokine
2) Confidence 0.47 Published 2008 Journal J Dig Dis Section Abstract Doc Link 18956590 Disease Relevance 1.16 Pain Relevance 0.28
All three chemicals induced Nrf2, but NF-kappaB binding activity was only increased after BSO treatment.
NF-kappaB Binding (binding) of
3) Confidence 0.46 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.53 Pain Relevance 0.13
All three chemicals induced Nrf2, but NF-kappaB binding activity was only increased after BSO treatment.
NF-kappaB Binding (activity) of
4) Confidence 0.46 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.53 Pain Relevance 0.13
NF-kB and NF-IL6 DNA binding occurred constitutively in control mouse liver.
NF-kB Binding (binding) of in liver
5) Confidence 0.45 Published 1995-1996 Journal J. Inflamm. Section Abstract Doc Link 9117441 Disease Relevance 0.37 Pain Relevance 0.50
Furthermore, Cardiospermum halicacabum L. ethanol extract inhibited the TNF-alpha induced DNA binding activity of NF-kappaB, which was associated with decreased p65 protein level in the nucleus in Jurkat cells.
NF-kappaB Binding (binding) of in nucleus
6) Confidence 0.42 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19393729 Disease Relevance 0.06 Pain Relevance 0
B is not associated with formation of NFKB1 (p50) dimers [6].
NFKB1 Binding (formation) of
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.35 Pain Relevance 0.13
B is not associated with formation of NFKB1 (p50) dimers [6].
p50 Neg (not) Binding (formation) of
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.35 Pain Relevance 0.14
B is not associated with formation of NFKB1 (p50) dimers [6].
p50 Neg (not) Binding (associated) of
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.35 Pain Relevance 0.14
Finally, there are combinatorial interactions at the level of the promoter between NF-kappaB, its coactivators, and other transcription factors, several of which are activated by MAPK and cytokine signaling pathways.
NF-kappaB Binding (interactions) of associated with cytokine
10) Confidence 0.37 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14555789 Disease Relevance 1.07 Pain Relevance 0.27
Of the compounds that are known to be NF-kappaB antagonists, the most practical for current use may be the nonsteroidal anti-inflammatory drugs aspirin, salicylic acid, and sulindac, each of which binds to and inhibits Ikappa kinase- beta, a central mediator of NF-kappa activation; the low millimolar plasma concentrations of salicylate required for effective inhibition of this kinase in vivo can be achieved with high-dose regimens traditionally used to manage rheumatic disorders.
NF-kappaB Binding (binds) of in plasma associated with aspirin, inflammation, antagonist and cinod
11) Confidence 0.37 Published 2006 Journal Integr Cancer Ther Section Abstract Doc Link 16880431 Disease Relevance 0.68 Pain Relevance 0.23
Nuclear extracts of purified, aspirin-treated DC revealed a decreased NF-kappaB DNA-binding activity, whereas Ab supershift analysis indicated that aspirin targeted primarily NF-kappaB p50.
NF-kappaB Binding (targeted) of associated with aspirin
12) Confidence 0.36 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.07 Pain Relevance 0.45
In fact, NF-kappaB binding activity decreased after exposure to NAPQI and DNCB.
NF-kappaB Binding (binding) of
13) Confidence 0.36 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.53 Pain Relevance 0.12
These data taken together led us to reinforce the hypothesis in the literature that the anti-inflammatory effect of propolis may be a due to inhibition of iNOS gene expression, through interference with NF-kappaB sites in the iNOS promoter.
NF-kappaB Binding (interference) of associated with inflammation
14) Confidence 0.36 Published 2006 Journal Planta Med. Section Abstract Doc Link 16902858 Disease Relevance 0.43 Pain Relevance 0.38
It downregulated phosphorylation of p65 by inhibiting upstream kinases, such as protein kinase A and casein kinase II, but did not alter NF-kappaB DNA-binding activity.
NF-kappaB Binding (binding) of
15) Confidence 0.35 Published 2007 Journal Cell Death Differ. Section Abstract Doc Link 16645640 Disease Relevance 0.51 Pain Relevance 0.08
Nuclear extracts of purified, aspirin-treated DC revealed a decreased NF-kappaB DNA-binding activity, whereas Ab supershift analysis indicated that aspirin targeted primarily NF-kappaB p50.
NF-kappaB Binding (activity) of associated with aspirin
16) Confidence 0.35 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.08 Pain Relevance 0.42
Nuclear extracts of purified, aspirin-treated DC revealed a decreased NF-kappaB DNA-binding activity, whereas Ab supershift analysis indicated that aspirin targeted primarily NF-kappaB p50.
NF-kappaB Binding (binding) of associated with aspirin
17) Confidence 0.35 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.08 Pain Relevance 0.42
The NF-kappaB DNA-binding activity in whole-lung extract was evaluated by electrophoretic mobility shift assay.
NF-kappaB Binding (binding) of in lung
18) Confidence 0.34 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.26 Pain Relevance 0.19
The NF-kappaB DNA-binding activity in whole-lung extract was evaluated by electrophoretic mobility shift assay.
NF-kappaB Binding (activity) of in lung
19) Confidence 0.34 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.26 Pain Relevance 0.19
Co-immunoprecipitation studies revealed an interaction of Hsp70 with NF-kappaB and IkappaBalpha, but not with IkappaB kinase, IKKgamma, suggesting that Hsp70 binds to the NF-kappaB:IkappaB complex preventing IkappaB phosphorylation by IKK.
IkappaB Binding (complex) of
20) Confidence 0.34 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.71 Pain Relevance 0.26

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