INT6676

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Context Info
Confidence 0.04
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0

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nucleoplasm (CREB1) mitochondrion (CREB1) cell-cell signaling (Edn1)
cytoplasm (Edn1) signal transduction (CREB1) extracellular space (Edn1)
Anatomy Link Frequency
nervous system 3
Edn1 (Rattus norvegicus)
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Glioma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that receptor binding of endothelin-1 leads to rapid changes in the expression of immediate-early response genes which may cause more prolonged changes in the expression of AP-1 and/or CREB target genes in the nervous system.
endothelin-1 Binding (binding) of in nervous system Regulation (changes) of Gene_expression (expression) of CREB in nervous system
1) Confidence 0.04 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1331650 Disease Relevance 0.15 Pain Relevance 0

General Comments

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