INT66776

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Context Info
Confidence 0.35
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.48
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcne2) lysosome (Kcne2)
Anatomy Link Frequency
muscle 2
coronary artery 1
tube 1
Kcne2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
beta blocker 1 99.84 Very High Very High Very High
Sciatic nerve 48 90.12 High High
analgesia 5 81.20 Quite High
Analgesic 1 25.00 Low Low
Bioavailability 1 16.60 Low Low
ischemia 8 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 4 99.88 Very High Very High Very High
Nerve Compression Syndromes 120 99.20 Very High Very High Very High
Myocardial Infarction 4 98.20 Very High Very High Very High
Cancer 5 93.12 High High
Acute Monocytic Leukemia 1 80.16 Quite High
Hypothermia 4 79.00 Quite High
Injury 68 77.20 Quite High
Colon Cancer 1 75.92 Quite High
Coma 1 69.00 Quite High
Nervous System Injury 16 48.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 38 degrees C, CMRO2 in the DB and NE groups was 7.92 +/- 1.05 and 6.4 +/- 0.80 mL x 100 g-1.min-1 and decreased to 50% of normal (3.95 +/- 0.70 and 3.32 +/- 0.40 mL x 100 g-1.min-1, respectively) during TP isoelectricity for a functional:basal CMRO2 distribution of 50% +/- 4% and 50% +/- 4%.
Negative_regulation (decreased) of min-1
1) Confidence 0.35 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8942597 Disease Relevance 0.27 Pain Relevance 0.08
In this study, there was an ~50% decrease in the expression levels of miR-1 and miR-133a at 3 and 6 months after entrapment as well as after 1 and 3 months of decompression.
Negative_regulation (decrease) of miR-1
2) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.43 Pain Relevance 0.04
Regarding the muscle-specific miRNAs, real-time RT-PCR analysis revealed an ~50% decrease in miR-1 and miR-133a expression levels at 3 and 6 months after entrapment, whereas miR-1 and miR-133a levels were unchanged and were decreased after decompression at 1 and 3 months.
Negative_regulation (decreased) of miR-1 in muscle
3) Confidence 0.05 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2927509 Disease Relevance 0.55 Pain Relevance 0.08
Regarding the muscle-specific miRNAs, real-time RT-PCR analysis revealed an ~50% decrease in miR-1 and miR-133a expression levels at 3 and 6 months after entrapment, whereas miR-1 and miR-133a levels were unchanged and were decreased after decompression at 1 and 3 months.
Negative_regulation (decrease) of miR-1 in muscle
4) Confidence 0.05 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2927509 Disease Relevance 0.52 Pain Relevance 0.08
After nerve entrapment using a silastic tube, we observed the downregulation of miR-1 and miR-133a in the soleus muscle at 3 months after its insertion that lasted until at least the 6-months time point (Figure 3).
Negative_regulation (downregulation) of miR-1 in tube associated with nerve compression syndromes
5) Confidence 0.05 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.10 Pain Relevance 0
Recent studies demonstrated the increase of miR-1 in coronary artery diseases (CAD) and miR-1 is downregulated by beta-blocker propranolol in rat model of myocardial infarction [29].
Negative_regulation (downregulated) of miR-1 in coronary artery associated with coronary artery disease, beta blocker and myocardial infarction
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0.60 Pain Relevance 0.05

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