INT66779

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 79
Total Number 80
Disease Relevance 6.43
Pain Relevance 60.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
brain 15
spinal cord 7
central nervous system 3
pons 2
corpus striatum 2
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 584 100.00 Very High Very High Very High
Opioid 169 100.00 Very High Very High Very High
opioid receptor 103 100.00 Very High Very High Very High
Pain 42 100.00 Very High Very High Very High
tolerance 15 100.00 Very High Very High Very High
Endogenous opioid 12 100.00 Very High Very High Very High
Buprenorphine 176 99.98 Very High Very High Very High
analgesia 27 99.98 Very High Very High Very High
narcan 57 99.84 Very High Very High Very High
Morphine 41 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Epilepsy 26 100.00 Very High Very High Very High
Diuresis 6 99.40 Very High Very High Very High
Hyperalgesia 9 96.96 Very High Very High Very High
Nociception 25 96.52 Very High Very High Very High
Pain 83 96.08 Very High Very High Very High
Appetite Loss 4 94.48 High High
Urological Neuroanatomy 9 94.08 High High
Affective Disorder 2 89.08 High High
Sleep Disorders 10 84.80 Quite High
Stress 8 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggested that EA could modulate immune response via the interaction between Orphanin FQ and IL-1beta.
Orphanin FQ Binding (interaction) of associated with orphanin and electroacupuncture
1) Confidence 0.48 Published 2002 Journal Acupunct Electrother Res Section Abstract Doc Link 12044017 Disease Relevance 0.23 Pain Relevance 0.61
Aside from this similarity, the association of nociceptin to the endogenous opioid peptide systems and the functional importance of this new peptide in vivo are not completely known.
nociceptin Binding (association) of associated with orphanin and endogenous opioid
2) Confidence 0.48 Published 1997 Journal Life Sci. Section Abstract Doc Link 8995537 Disease Relevance 0.06 Pain Relevance 0.68
Presence and characterization of nociceptin (orphanin FQ) receptor binding in adult rat and human fetal hypothalamus.
nociceptin Binding (binding) of in hypothalamus associated with orphanin
3) Confidence 0.47 Published 1997 Journal Brain Res. Section Title Doc Link 9262184 Disease Relevance 0 Pain Relevance 0.63
Buprenorphine interacts with orphanin FQ/nociceptin receptor ORL-1 in the spinal cord and the brain stem.
orphanin FQ Binding (interacts) of in brain stem associated with orphanin, spinal cord and buprenorphine
4) Confidence 0.47 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682375 Disease Relevance 0.08 Pain Relevance 2.41
The heptadecapeptide, orphanin FQ/nociceptin (OFQ/N), binds with high affinity to the ORL-1/KOR-3 opioid receptor clone, yet binds poorly with traditional opioid receptors.
orphanin FQ Binding (binds) of associated with orphanin and opioid receptor
5) Confidence 0.47 Published 2001 Journal Brain Res. Section Abstract Doc Link 11430891 Disease Relevance 0.33 Pain Relevance 0.56
Distribution of nociceptin and Ro64-6198 activated [35S]-GTPgammaS binding in the rat brain.
nociceptin Binding (binding) of in brain associated with orphanin
6) Confidence 0.45 Published 2006 Journal Neuropeptides Section Title Doc Link 16403422 Disease Relevance 0.18 Pain Relevance 0.63
The present study also demonstrates an interaction between nociceptin and opioids in the arcuate nucleus of the hypothalamus.
nociceptin Binding (interaction) of in hypothalamus associated with orphanin and opioid
7) Confidence 0.42 Published 2004 Journal Brain Res. Section Abstract Doc Link 15464746 Disease Relevance 0.24 Pain Relevance 0.92
There were regional variations in the specific [3H]nociceptin binding to crude membranes from the rat brain: a relatively high density of [3H]nociceptin binding in the cerebral cortex, hippocampus, thalamus and midbrain, moderately dense binding in the corpus striatum and pons/medulla oblongata, and the lowest density of binding in the cerebellum.
nociceptin Binding (binding) of in medulla oblongata associated with medulla, orphanin, midbrain, thalamus, hippocampus and cerebral cortex
8) Confidence 0.41 Published 2001 Journal Biol. Pharm. Bull. Section Abstract Doc Link 11510482 Disease Relevance 0 Pain Relevance 1.21
Since it is unlikely that nociceptin acts by direct binding to opioid receptors, these results suggest a possible interaction between the nociceptin/ORL1 and opioid systems in the dorsal horn of the rat spinal cord.
nociceptin Binding (interaction) of in spinal cord associated with orphanin, dorsal horn, opioid receptor, opioid and spinal cord
9) Confidence 0.39 Published 2002 Journal Brain Res. Section Abstract Doc Link 12113955 Disease Relevance 0 Pain Relevance 1.46
In vivo metabolism of nociceptin/orphanin FQ in rat hippocampus.
nociceptin Binding (metabolism) of in hippocampus associated with orphanin and hippocampus
10) Confidence 0.37 Published 1999 Journal Neuroreport Section Title Doc Link 10094136 Disease Relevance 0 Pain Relevance 0.50
Nociceptin bound with picomolar affinity, dynorphin A with nanomolar affinity, naloxone and dynorphan A(1-8) with micromolar while des-Tyr1-dynorphin (dynorphin A(2-17)), several other opioids, morphine and benzomorphans failed to compete for binding at 1-10 microM.
Nociceptin Binding (bound) of associated with dynorphin, orphanin, narcan, opioid and morphine
11) Confidence 0.35 Published 1997 Journal Brain Res. Section Abstract Doc Link 9262184 Disease Relevance 0 Pain Relevance 0.65
Three opioids were used: morphine (MOR), a mu-agonist, butorphanol tartrate (BT), a mixed mu/kappa-agonist, and nociceptin/orphanin FQ (N/OFQ), which binds to an ORL1 receptor.
orphanin FQ Binding (binds) of associated with orphanin, butorphanol, agonist, opioid and morphine
12) Confidence 0.35 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 11004021 Disease Relevance 0.35 Pain Relevance 1.10
Nociceptin/orphanin FQ (NC) binds with high affinity to the opioid receptor-like1 (ORL1) receptor.
orphanin FQ Binding (binds) of associated with orphanin and opioid receptor
13) Confidence 0.35 Published 2000 Journal Peptides Section Abstract Doc Link 10998542 Disease Relevance 0.08 Pain Relevance 0.50
Membranes prepared from the olfactory nerve-glomerular layer (ON-G layer), external plexiform layer (EP layer) and granule cell layer (GR layer) displayed specific binding sites for [(3)H]-nociceptin/orphanin FQ ([(3)H]Noc/OFQ).
orphanin FQ Binding (binding) of in glomerular layer associated with orphanin
14) Confidence 0.35 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11413235 Disease Relevance 0 Pain Relevance 0.30
In vitro studies have shown that [Phe1Psi(CH2-NH)Gly2]OFQ/N(1-13)-NH2 (referred to as [FG]OFQ/N(1-13)-NH2) is the first selective antagonist to prevent the binding of the endogenous ligand orphanin FQ/Nociceptin (OFQ/N) at the orphan opioid-like receptor.
orphanin FQ Binding (binding) of associated with orphanin, antagonist and opioid
15) Confidence 0.35 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087001 Disease Relevance 0.06 Pain Relevance 0.36
Identification of central nervous system sites involved in the water diuresis response elicited by central microinjection of nociceptin/ Orphanin FQ in conscious rats via c-Fos and inducible cAMP early repressor immunocytochemistry.
nociceptin Binding (microinjection) of in central nervous system associated with diuresis, orphanin and central nervous system
16) Confidence 0.34 Published 2007 Journal J. Neuroendocrinol. Section Title Doc Link 17532793 Disease Relevance 0.10 Pain Relevance 0.57
Opioid receptor like 1 (ORL1) receptor is a novel member of the opioid receptor family, which was not bound by any of the typical opioid receptor ligands but bound by the recently discovered nociceptin (also termed orphanin FQ) with high affinity.
orphanin FQ Binding (bound) of associated with orphanin and opioid receptor
17) Confidence 0.33 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10963896 Disease Relevance 0.07 Pain Relevance 0.41
Opioid receptor like 1 (ORL1) receptor is a novel member of the opioid receptor family, which was not bound by any of the typical opioid receptor ligands but bound by the recently discovered nociceptin (also termed orphanin FQ) with high affinity.
nociceptin Binding (bound) of associated with orphanin and opioid receptor
18) Confidence 0.33 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10963896 Disease Relevance 0.07 Pain Relevance 0.40
The present results are the first to show that there is no cross-tolerance between orphanin FQ and morphine in eliciting spinal antinociception, supporting the notion that orphanin FQ produced spinal antinociception through a site which is different from classical opioid receptors.
orphanin FQ Neg (no) Binding (cross-tolerance) of in spinal associated with antinociception, orphanin, tolerance, opioid receptor and morphine
19) Confidence 0.33 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9058420 Disease Relevance 0.08 Pain Relevance 1.95
Nociceptin and its analogue, [Phe1 psi(CH2-NH)-Gly2]nociceptin(1-13)NH2 were found to be potent inhibitors of [3H]nociceptin binding to crude membranes from the brain and spinal cord, while opioid ligands such as naloxone-benzoylhydrazone, naltrindole and nor-binaltorphimine, exhibited an inhibitory effect only at high concentrations.
Nociceptin Binding (binding) of in brain associated with orphanin, narcan, opioid and spinal cord
20) Confidence 0.32 Published 2001 Journal Biol. Pharm. Bull. Section Abstract Doc Link 11510482 Disease Relevance 0 Pain Relevance 1.16

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