INT66782

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Context Info
Confidence 0.28
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.42
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
prefrontal 2
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 13 100.00 Very High Very High Very High
Kappa opioid receptor 12 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
cocaine 14 99.36 Very High Very High Very High
alcohol 3 97.80 Very High Very High Very High
mu opioid receptor 1 93.32 High High
addiction 4 92.92 High High
MU agonist 1 92.80 High High
Endogenous opioid 5 90.88 High High
Dopamine 5 89.52 High High
Disease Link Frequency Relevance Heat
Schizophrenia 3 97.72 Very High Very High Very High
Manic Depressive Disorder 2 97.12 Very High Very High Very High
Neuroblastoma 2 96.12 Very High Very High Very High
Cocaine Dependence 3 93.24 High High
Death 1 87.52 High High
Suicidal Behaviour 1 86.72 High High
Affective Disorder 1 75.00 Quite High
Mental Disorders 1 71.44 Quite High
Depression 1 68.84 Quite High
Alcohol Addiction 1 68.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction.
Negative_regulation (disruption) of Gene_expression (expression) of kappa opioid receptor associated with addiction, dynorphin, kappa opioid receptor and cocaine
1) Confidence 0.28 Published 1996 Journal J Addict Dis Section Abstract Doc Link 8943583 Disease Relevance 0.38 Pain Relevance 1.18
We observed a significant decrease in the expression of opioid peptide precursors (proopiomelanocortin, proenkephalin, and prodynorphin) and of the kappa opioid receptor after 48 and 72 h of EtOH exposure (10 and 40 mM).
Negative_regulation (decrease) of Gene_expression (expression) of kappa opioid receptor associated with kappa opioid receptor and opioid
2) Confidence 0.28 Published 2008 Journal FASEB J. Section Abstract Doc Link 17934066 Disease Relevance 0.17 Pain Relevance 0.65
Dynorphin gene expression, dynorphin peptides, and kappa-opioid receptor gene expression and binding have been shown to be altered in response to cocaine administration.
Negative_regulation (altered) of Gene_expression (expression) of kappa-opioid receptor gene associated with dynorphin, kappa opioid receptor and cocaine
3) Confidence 0.22 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862779 Disease Relevance 0.07 Pain Relevance 1.31
Overall, our data do not provide strong evidence for impaired prodynorphin or kappa opioid receptor mRNA levels in the dorsolateral prefrontal or cingulate cortices of schizophrenic, bipolar disorder, or major depressed subjects.
Negative_regulation (impaired) of Gene_expression (levels) of kappa opioid receptor mRNA in prefrontal associated with manic depressive disorder, kappa opioid receptor and schizophrenia
4) Confidence 0.10 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11576758 Disease Relevance 0.79 Pain Relevance 0.27

General Comments

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