INT66794

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 7.84
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)
Anatomy Link Frequency
T cell 3
monocyte 2
stromal cell 2
blood 1
endothelium 1
Vcam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 50 100.00 Very High Very High Very High
cytokine 14 100.00 Very High Very High Very High
rheumatoid arthritis 135 99.70 Very High Very High Very High
Neuritis 6 95.96 Very High Very High Very High
Pain 2 90.84 High High
Sciatic nerve 3 86.16 High High
cINOD 6 85.60 High High
tolerance 10 80.88 Quite High
Osteoarthritis 1 75.08 Quite High
Angina 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 58 100.00 Very High Very High Very High
Adhesions 47 100.00 Very High Very High Very High
Atherosclerosis 37 100.00 Very High Very High Very High
Insulin Resistance 24 100.00 Very High Very High Very High
Rheumatoid Arthritis 148 99.70 Very High Very High Very High
Apoptosis 12 99.38 Very High Very High Very High
Experimental Autoimmune Neuritis 6 96.92 Very High Very High Very High
Hyperlipidemia 1 93.48 High High
Pain 2 90.84 High High
Cardiovascular Disease 23 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The early increase of T cell apoptosis following disruption of VLA-4/VCAM-1 interaction may reflect a novel signaling component of proapoptotic pathways.
VCAM-1 Binding (interaction) of in T cell associated with apoptosis
1) Confidence 0.48 Published 2002 Journal Acta Neuropathol. Section Abstract Doc Link 11810178 Disease Relevance 0.70 Pain Relevance 0.19
We characterized the early effects of anti-very late antigen (VLA-4) and its counterligand vascular cell adhesion molecule-1 (VCAM-1) antibody therapy on T cell infiltration and apoptosis in adoptive transfer experimental autoimmune neuritis of female Lewis rats.
vascular cell adhesion molecule-1 Binding (counterligand) of in T cell associated with experimental autoimmune neuritis, apoptosis, neuritis and adhesions
2) Confidence 0.37 Published 2002 Journal Acta Neuropathol. Section Abstract Doc Link 11810178 Disease Relevance 0.68 Pain Relevance 0.20
It was reported that among adhesion molecules, VCAM-1 plays a major role in the progression of atherosclerosis (31), can be a useful marker reflecting vascular endothelial activation (24,30,32,33) and is associated with future cardiovascular events (34).
VCAM-1 Binding (associated) of associated with atherosclerosis and adhesions
3) Confidence 0.36 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 1.18 Pain Relevance 0.38
The consumption of olive oil as a single item showed a significant inverse association, and a Mediterranean-diet score excluding olive oil was also inversely associated with TNF-alpha and VCAM-1 serum levels in coronary venous blood.
VCAM-1 Binding (associated) of in blood
4) Confidence 0.35 Published 2005 Journal Eur J Nutr Section Body Doc Link 16151968 Disease Relevance 0.06 Pain Relevance 0
We characterized the early effects of anti-very late antigen (VLA-4) and its counterligand vascular cell adhesion molecule-1 (VCAM-1) antibody therapy on T cell infiltration and apoptosis in adoptive transfer experimental autoimmune neuritis of female Lewis rats.
VCAM-1 Binding (counterligand) of in T cell associated with experimental autoimmune neuritis, apoptosis, neuritis and adhesions
5) Confidence 0.32 Published 2002 Journal Acta Neuropathol. Section Abstract Doc Link 11810178 Disease Relevance 0.68 Pain Relevance 0.21
The association between VCAM-1 and the Mediterranean-diet score had an adjusted beta coefficient of -35.1 ng/ml (95% coefficient interval, CI: -63.5 to -6.7).
VCAM-1 Binding (association) of
6) Confidence 0.26 Published 2005 Journal Eur J Nutr Section Body Doc Link 16151968 Disease Relevance 0.07 Pain Relevance 0
Regulation of hematopoietic cell development is mediated, in part, through interaction of progenitor cells with stromal cell vascular cell adhesion molecule-1 (VCAM-1).
VCAM-1 Binding (interaction) of in stromal cell associated with adhesions
7) Confidence 0.21 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.10 Pain Relevance 0
Regulation of hematopoietic cell development is mediated, in part, through interaction of progenitor cells with stromal cell vascular cell adhesion molecule-1 (VCAM-1).
vascular cell adhesion molecule-1 Binding (interaction) of in stromal cell associated with adhesions
8) Confidence 0.18 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.10 Pain Relevance 0
The molecule exhibits activity in a scintillation-proximity assay for the inhibition of the interaction between the integrin very-late antigen-4 (VLA-4; alpha 4 beta 1) and vascular-cell-adhesion molecule-1 (VCAM-1).
VCAM-1 Binding (interaction) of associated with adhesions
9) Confidence 0.17 Published 1996 Journal Eur. J. Biochem. Section Abstract Doc Link 8973654 Disease Relevance 0.10 Pain Relevance 0.09
The molecule exhibits activity in a scintillation-proximity assay for the inhibition of the interaction between the integrin very-late antigen-4 (VLA-4; alpha 4 beta 1) and vascular-cell-adhesion molecule-1 (VCAM-1).
vascular-cell-adhesion molecule-1 Binding (interaction) of associated with adhesions
10) Confidence 0.14 Published 1996 Journal Eur. J. Biochem. Section Abstract Doc Link 8973654 Disease Relevance 0.10 Pain Relevance 0.08
The aim of this cross-sectional study was to assess the association of insulin resistance (IR) with inflammatory molecules C-reactive protein (CRP), interleukin 6 (IL-6), vascular cell adhesion molecule 1 (VCAM-1), and monocyte chemotactic protein 1 (MCP-1) in urban South Indian subjects.
VCAM-1 Binding (association) of in monocyte associated with inflammation, insulin resistance and adhesions
11) Confidence 0.12 Published 2006 Journal Metab. Clin. Exp. Section Abstract Doc Link 16919544 Disease Relevance 1.12 Pain Relevance 0.12
The aim of this cross-sectional study was to assess the association of insulin resistance (IR) with inflammatory molecules C-reactive protein (CRP), interleukin 6 (IL-6), vascular cell adhesion molecule 1 (VCAM-1), and monocyte chemotactic protein 1 (MCP-1) in urban South Indian subjects.
vascular cell adhesion molecule 1 Binding (association) of in monocyte associated with inflammation, insulin resistance and adhesions
12) Confidence 0.12 Published 2006 Journal Metab. Clin. Exp. Section Abstract Doc Link 16919544 Disease Relevance 1.12 Pain Relevance 0.12
It has previously been reported that sickle reticulocytes express the alpha 4 beta 1 integrin receptor and bind to cytokine-activated endothelium via an alpha 4 beta 1/vascular-cell adhesion molecule-1 (VCAM-1) interaction.
VCAM-1 Binding (bind) of in endothelium associated with adhesions and cytokine
13) Confidence 0.08 Published 1996 Journal Blood Section Abstract Doc Link 8943872 Disease Relevance 0.50 Pain Relevance 0.14
Other studies on patients with RA have shown an association between IMT and VWF [8] as well as sVCAM-1 [27].
sVCAM-1 Binding (association) of associated with rheumatoid arthritis
14) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945061 Disease Relevance 1.32 Pain Relevance 0.33

General Comments

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