INT66804

Context Info Confidence 0.56 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.79 Pain Relevance 2.26

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)

Anatomy Link Frequency paw 2 Tnf (Rattus norvegicus)

Pain Link Frequency Relevance Heat withdrawal 12 100.00 abatacept 7 99.64 diclofenac 2 98.80 antagonist 1 95.88 Eae 50 89.24 Thermal hyperalgesia 11 87.36 allodynia 11 86.40 rheumatoid arthritis 2 85.68 psoriasis 1 80.80 Intracerebroventricular 1 75.00

Disease Link Frequency Relevance Heat Necrosis 6 100.00 Cancer 6 100.00 Nociception 4 98.84 Rheumatoid Arthritis 4 95.20 Hypersensitivity Vasculitis 2 89.44 Injury 60 89.24 Hyperalgesia 16 87.36 Neuropathic Pain 35 86.40 INFLAMMATION 15 64.32 Nervous System Injury 19 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The TNF-alpha (10 pg)-induced reduction in paw withdrawal latency was blocked by simultaneous injection of diclofenac (1 ng), a cyclooxygenase inhibitor, or interleukin-1 receptor antagonist (IL-1 ra, 10 ng).

Negative_regulation (blocked) of Negative_regulation (reduction) of TNF-alpha in paw associated with antagonist, rheumatoid arthritis, diclofenac and withdrawal

1) Confidence 0.56 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 8945729 Disease Relevance 1.15 Pain Relevance 0.54

ELISA revealed a significantly lower baseline level of TNF-?

Negative_regulation (revealed) of Negative_regulation (level) of TNF

2) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 1.03 Pain Relevance 0.97

RESULTS: Deafferentation reversed the inhibitory effect of lipid-rich nutrition on systemic levels of tumor necrosis factor-alpha and interleukin-6, and on intestinal leakage of horseradish peroxidase and bacterial translocation.

Negative_regulation (reversed) of Negative_regulation (effect) of tumor necrosis factor-alpha

3) Confidence 0.18 Published 2010 Journal Ann. Surg. Section Body Doc Link 20585240 Disease Relevance 0.06 Pain Relevance 0

Abatacept seems to be more immunosuppressive than tumor necrosis factor alpha blockers.

Negative_regulation (immunosuppressive) of Negative_regulation (blockers) of tumor necrosis factor alpha associated with necrosis, cancer and abatacept

4) Confidence 0.04 Published 2006 Journal J Dermatolog Treat Section Abstract Doc Link 16971318 Disease Relevance 0.55 Pain Relevance 0.75

General Comments

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