INT66804

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Context Info
Confidence 0.56
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.79
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
paw 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 12 100.00 Very High Very High Very High
abatacept 7 99.64 Very High Very High Very High
diclofenac 2 98.80 Very High Very High Very High
antagonist 1 95.88 Very High Very High Very High
Eae 50 89.24 High High
Thermal hyperalgesia 11 87.36 High High
allodynia 11 86.40 High High
rheumatoid arthritis 2 85.68 High High
psoriasis 1 80.80 Quite High
Intracerebroventricular 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Necrosis 6 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Nociception 4 98.84 Very High Very High Very High
Rheumatoid Arthritis 4 95.20 Very High Very High Very High
Hypersensitivity Vasculitis 2 89.44 High High
Injury 60 89.24 High High
Hyperalgesia 16 87.36 High High
Neuropathic Pain 35 86.40 High High
INFLAMMATION 15 64.32 Quite High
Nervous System Injury 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TNF-alpha (10 pg)-induced reduction in paw withdrawal latency was blocked by simultaneous injection of diclofenac (1 ng), a cyclooxygenase inhibitor, or interleukin-1 receptor antagonist (IL-1 ra, 10 ng).
Negative_regulation (blocked) of Negative_regulation (reduction) of TNF-alpha in paw associated with antagonist, rheumatoid arthritis, diclofenac and withdrawal
1) Confidence 0.56 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 8945729 Disease Relevance 1.15 Pain Relevance 0.54
ELISA revealed a significantly lower baseline level of TNF-?
Negative_regulation (revealed) of Negative_regulation (level) of TNF
2) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 1.03 Pain Relevance 0.97
RESULTS: Deafferentation reversed the inhibitory effect of lipid-rich nutrition on systemic levels of tumor necrosis factor-alpha and interleukin-6, and on intestinal leakage of horseradish peroxidase and bacterial translocation.
Negative_regulation (reversed) of Negative_regulation (effect) of tumor necrosis factor-alpha
3) Confidence 0.18 Published 2010 Journal Ann. Surg. Section Body Doc Link 20585240 Disease Relevance 0.06 Pain Relevance 0
Abatacept seems to be more immunosuppressive than tumor necrosis factor alpha blockers.
Negative_regulation (immunosuppressive) of Negative_regulation (blockers) of tumor necrosis factor alpha associated with necrosis, cancer and abatacept
4) Confidence 0.04 Published 2006 Journal J Dermatolog Treat Section Abstract Doc Link 16971318 Disease Relevance 0.55 Pain Relevance 0.75

General Comments

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