INT6681

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Context Info
Confidence 0.65
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 1.78
Pain Relevance 5.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
neurons 6
cerebral cortex 3
projection neurons 2
striatum 2
dopamine neurons 2
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 113 100.00 Very High Very High Very High
cerebral cortex 74 100.00 Very High Very High Very High
dopamine receptor 43 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
projection neuron 2 99.12 Very High Very High Very High
Nucleus accumbens 2 98.60 Very High Very High Very High
Substantia nigra 7 98.08 Very High Very High Very High
Catecholamine 8 97.92 Very High Very High Very High
agonist 7 96.72 Very High Very High Very High
alcohol 6 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 180 99.36 Very High Very High Very High
Disease 11 92.80 High High
Movement Disorders 3 84.24 Quite High
Alcohol Addiction 1 83.04 Quite High
Drug Dependence 5 75.00 Quite High
Opiate Addiction 1 62.48 Quite High
Recurrence 2 25.00 Low Low
Cognitive Disorder 22 5.00 Very Low Very Low Very Low
Stress 18 5.00 Very Low Very Low Very Low
Body Weight 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This DRD2 overexpression similarly produced significant reductions in ethanol non-preferring rats, in both alcohol preference (16%) and alcohol intake (75%).
Positive_regulation (overexpression) of Gene_expression (overexpression) of DRD2 associated with alcohol
1) Confidence 0.65 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15288384 Disease Relevance 0.22 Pain Relevance 0.68
Reserpine treatment stimulates enkephalin and D2 dopamine receptor gene expression in the rat striatum.
Positive_regulation (stimulates) of Gene_expression (expression) of D2 dopamine receptor in striatum associated with dopamine receptor and enkephalin
2) Confidence 0.50 Published 1992 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1331675 Disease Relevance 0 Pain Relevance 0.65
In view of previous results after 6-hydroxydopamine lesions in adults, it appears that the behavioral differences observed after adult or neonatal 6-hydroxydopamine lesions are accompanied by a similar alteration of GAD67, preproenkephalin and dopamine D2 receptor gene expression in presumed striatal projection neurons.
Positive_regulation (alteration) of Gene_expression (expression) of dopamine D2 receptor gene in projection neurons associated with dopamine and projection neuron
3) Confidence 0.42 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.43
The present study demonstrates that bilateral 6-hydroxydopamine lesions of dopamine neurons in neonate rats are able to induce a long-term and widespread alteration in the expression of genes encoding for GAD67, preproenkephalin and dopamine D2 receptor in the striatum.
Positive_regulation (induce) of Gene_expression (expression) of dopamine D2 receptor in dopamine neurons associated with dopamine
4) Confidence 0.42 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.51
Striatopallidal neurons show a 6-OHDA-induced elevation in their specific expression of messenger RNAs (mRNAs) encoding the D2 dopamine receptor and enkephalin, which is reversed by subsequent continuous treatment with the D2 agonist quinpirole.
Positive_regulation (elevation) of Gene_expression (expression) of D2 dopamine receptor in neurons associated with dopamine receptor, agonist and enkephalin
5) Confidence 0.37 Published 1990 Journal Science Section Abstract Doc Link 2147780 Disease Relevance 0.26 Pain Relevance 0.63
Thus, the differential effects of dopamine on striatonigral and striatopallidal neurons are mediated by their specific expression of D1 and D2 dopamine receptor subtypes, respectively.
Positive_regulation (mediated) of Gene_expression (expression) of D2 dopamine receptor in neurons associated with dopamine and dopamine receptor
6) Confidence 0.37 Published 1990 Journal Science Section Abstract Doc Link 2147780 Disease Relevance 0.19 Pain Relevance 0.61
Detailed microscopic analysis demonstrated a significant increase in D2 receptor mRNA in the two neuronal populations known to express the D2 receptor gene: medium-sized neurons previously identified as enkephalinergic neurons, and large-sized neurons previously identified as cholinergic neurons.
Positive_regulation (increase) of Gene_expression (express) of D2 receptor in neurons
7) Confidence 0.27 Published 1991 Journal Neuroscience Section Abstract Doc Link 1754061 Disease Relevance 0 Pain Relevance 0.08
Levels of D-2 receptor mRNA were also increased in the OT, though to a lesser degree.
Positive_regulation (increased) of Gene_expression (Levels) of D-2 receptor mRNA
8) Confidence 0.21 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657493 Disease Relevance 0 Pain Relevance 0.54
Real Time-PCR analysis showed that the dopamine D2 receptor gene expression in the cerebral cortex and cerebellum was significantly increased (p < 0.001) in diabetic condition and it reversed to near control value in insulin and curcumin treated diabetic rats (Figure 3 and 4).


Positive_regulation (increased) of in cerebellum Gene_expression (expression) of dopamine D2 in cerebral cortex associated with dopamine, diabetes mellitus and cerebral cortex
9) Confidence 0.13 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.55 Pain Relevance 0.66
This cell line is transfected with a eucaryotic expression vector containing the gene of the rat dopamine D2B-receptor (short isoform of the D2-receptor) (Bunzow et al., Nature, 1988).
Positive_regulation (transfected) of Gene_expression (transfected) of D2B-receptor associated with dopamine
10) Confidence 0.11 Published 1993 Journal Cell. Signal. Section Abstract Doc Link 8130078 Disease Relevance 0 Pain Relevance 0.33
Real Time-PCR analysis showed that the dopamine D2 receptor gene expression in the cerebral cortex and cerebellum was significantly increased (p < 0.001) in diabetic condition and it reversed to near control value in insulin and curcumin treated diabetic rats (Figure 3 and 4).


Positive_regulation (increased) of Gene_expression (expression) of dopamine D2 in cerebral cortex associated with dopamine, diabetes mellitus and cerebral cortex
11) Confidence 0.04 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.55 Pain Relevance 0.66

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