INT6682

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Context Info
Confidence 0.51
First Reported 1990
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 13
Total Number 17
Disease Relevance 2.17
Pain Relevance 8.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
nucleus accumbens 8
striatum 8
neurons 4
brain 4
cerebellum 3
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 127 100.00 Very High Very High Very High
dopamine receptor 64 100.00 Very High Very High Very High
cocaine 29 100.00 Very High Very High Very High
Catecholamine 8 100.00 Very High Very High Very High
Glutamate 8 100.00 Very High Very High Very High
antidepressant 4 100.00 Very High Very High Very High
substance P 17 99.88 Very High Very High Very High
Enkephalin 15 99.82 Very High Very High Very High
Nucleus accumbens 28 99.68 Very High Very High Very High
withdrawal 18 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 180 100.00 Very High Very High Very High
Opiate Addiction 3 98.04 Very High Very High Very High
Neuroblastoma 1 96.96 Very High Very High Very High
Movement Disorders 3 91.92 High High
Disease 10 88.32 High High
Cognitive Disorder 22 79.36 Quite High
Schizophrenia 2 70.12 Quite High
Cerebellar Diseases 6 63.52 Quite High
Urological Neuroanatomy 4 54.32 Quite High
Hyperinsulinism 2 51.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adaptive changes in the proenkephalin and D2 dopamine receptor mRNA expression after chronic cocaine in the nucleus accumbens and striatum of the rat.
Regulation (changes) of Gene_expression (expression) of D2 dopamine receptor mRNA in nucleus accumbens associated with nucleus accumbens, dopamine receptor, enkephalin and cocaine
1) Confidence 0.51 Published 1995 Journal Eur Neuropsychopharmacol Section Title Doc Link 8998398 Disease Relevance 0 Pain Relevance 0.66
In this study we have investigated the effect of the heptapeptide fragment on the expression of the brain dopamine D2 receptor mRNA and on the withdrawal reaction, as well, in morphine-dependent rats.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of dopamine D2 receptor in brain associated with dopamine, withdrawal and morphine
2) Confidence 0.44 Published 2003 Journal Peptides Section Abstract Doc Link 12576096 Disease Relevance 0.10 Pain Relevance 1.11
Substance P(1-7) affects the expression of dopamine D2 receptor mRNA in male rat brain during morphine withdrawal.
Regulation (affects) of Gene_expression (expression) of dopamine D2 receptor in brain associated with dopamine, withdrawal, morphine and substance p
3) Confidence 0.44 Published 2003 Journal Peptides Section Title Doc Link 12576096 Disease Relevance 0.14 Pain Relevance 1.20
The effects of neonatal 6-hydroxydopamine injections on the levels and cellular distribution of glutamate decarboxylase (GAD67), preproenkephalin and dopamine D2 receptor messenger RNAs were studied in the striatum of adult rats.
Regulation (effects) of Gene_expression (levels) of dopamine D2 receptor in striatum associated with dopamine and glutamate
4) Confidence 0.38 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.28
The effects of single and repeated cocaine administration on proenkephalin (PENK) and D2 dopamine receptor mRNA expression in the nucleus accumbens and striatum of the rat were studied.
Regulation (effects) of Gene_expression (expression) of D2 dopamine receptor mRNA in striatum associated with nucleus accumbens, dopamine receptor and cocaine
5) Confidence 0.37 Published 1995 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8998398 Disease Relevance 0 Pain Relevance 0.38
These results suggest that persistent inhibition of D2 dopamine receptors differentially regulates the expression of D1 and D2 dopamine receptor mRNA in striatum, and that the magnitude, duration and interval of inhibiting dopaminergic transmission may be important factors in regulating dopamine receptor mRNA expression.
Regulation (regulates) of Gene_expression (expression) of D2 dopamine receptor in striatum associated with dopamine receptor
6) Confidence 0.35 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7820070 Disease Relevance 0 Pain Relevance 0.96
This suggests that dopamine acts trans-synaptically to control D2 receptor gene expression in target striatal neurons.
Regulation (control) of Gene_expression (expression) of D2 receptor in neurons associated with dopamine
7) Confidence 0.33 Published 1991 Journal Neuroscience Section Abstract Doc Link 1754061 Disease Relevance 0 Pain Relevance 0.14
In the present study, quantitative in situ hybridization was used to analyse the effect of haloperidol treatment on D2 dopamine receptor gene expression in the rat caudate-putamen nucleus.
Spec (analyse) Regulation (effect) of Gene_expression (expression) of D2 dopamine receptor gene in nucleus associated with dopamine receptor
8) Confidence 0.33 Published 1991 Journal Neuroscience Section Abstract Doc Link 1754061 Disease Relevance 0 Pain Relevance 0.09
We investigated the effect of catecholamine depletion on gene expression for preproenkephalin A (PPA) and D2 dopamine receptor (D2R) in the rat nigrostriatal complex, using quantitative Northern blot analysis.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of D2 dopamine receptor associated with dopamine receptor and catecholamine
9) Confidence 0.33 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1331675 Disease Relevance 0 Pain Relevance 0.38
In pituitary cells, ethanol not only alters DRD2 splicing, but also diminishes the inhibition of prolactin secretion by the DRD2-specific analog bromocriptine [39].
Regulation (alters) of Gene_expression (splicing) of DRD2 in pituitary
10) Confidence 0.23 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0.10 Pain Relevance 0.21
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons.
Regulation (regulated) of Gene_expression (expression) of D2 dopamine receptor in neurons associated with dopamine receptor
11) Confidence 0.20 Published 1990 Journal Science Section Title Doc Link 2147780 Disease Relevance 0.26 Pain Relevance 0.51
Adaptive changes in the proenkephalin and D2 dopamine receptor mRNA expression after chronic cocaine in the nucleus accumbens and striatum of the rat.
Regulation (changes) of in striatum Gene_expression (expression) of D2 dopamine receptor mRNA in nucleus accumbens associated with nucleus accumbens, dopamine receptor, enkephalin and cocaine
12) Confidence 0.17 Published 1995 Journal Eur Neuropsychopharmacol Section Title Doc Link 8998398 Disease Relevance 0 Pain Relevance 0.66
Effect of antidepressant drugs on dopamine D1 and D2 receptor expression and dopamine release in the nucleus accumbens of the rat.
Regulation (Effect) of Gene_expression (expression) of D2 receptor in nucleus accumbens associated with nucleus accumbens, dopamine and antidepressant
13) Confidence 0.17 Published 1998 Journal Psychopharmacology (Berl.) Section Title Doc Link 9888623 Disease Relevance 0 Pain Relevance 1.03
RESULTS: Naltrexone treatment significantly decreased preprodynorphin expression in the nucleus accumbens, but neither naltrexone treatment nor ethanol consumption significantly affected dopamine D1 and D2 receptor mRNA expression.
Neg (neither) Regulation (affected) of Gene_expression (expression) of D2 receptor mRNA in nucleus accumbens
14) Confidence 0.15 Published 2001 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 11505043 Disease Relevance 0 Pain Relevance 0
The effects of single and repeated cocaine administration on proenkephalin (PENK) and D2 dopamine receptor mRNA expression in the nucleus accumbens and striatum of the rat were studied.
Regulation (effects) of in nucleus accumbens Gene_expression (expression) of D2 dopamine receptor mRNA in striatum associated with nucleus accumbens, dopamine receptor and cocaine
15) Confidence 0.13 Published 1995 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8998398 Disease Relevance 0 Pain Relevance 0.38
The present study showed that dopamine D2 receptors expression of cortex and cerebellum in diabetic rats where up regulated when compared to control.
Regulation (regulated) of Gene_expression (expression) of dopamine D2 in cerebellum associated with dopamine and diabetes mellitus
16) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.78 Pain Relevance 0.41
The present study showed that dopamine D2 receptors expression of cortex and cerebellum in diabetic rats where up regulated when compared to control.
Regulation (regulated) of in cortex Gene_expression (expression) of dopamine D2 in cerebellum associated with dopamine and diabetes mellitus
17) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.78 Pain Relevance 0.41

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