INT66823

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (PIGA) biosynthetic process (PIGA)
Anatomy Link Frequency
blood cells 3
PIGA (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 4 30.32 Quite Low
cva 17 25.68 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paroxysmal Nocturnal Hemoglobinuria 186 97.52 Very High Very High Very High
Hematological Disease 22 96.00 Very High Very High Very High
Disease 31 89.56 High High
Aplastic Anemia 17 64.68 Quite High
Myeloid Leukemia 2 35.84 Quite Low
Leukemia 3 35.64 Quite Low
Thrombosis 26 33.84 Quite Low
Abdominal Pain 4 30.32 Quite Low
Myocardial Infarction 1 28.88 Quite Low
Hemolytic Anemia 9 25.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The occurrence of the PIG-A mutation causing the absence of GPI-linked proteins on blood cells allows the PNH clone to flourish and to maintain hematopoiesis; thus it seems that the PIG-A mutation is nature's own gene therapy and the price that these patients have to pay is PNH.
Spec (seems) Positive_regulation (occurrence) of PIG-A in blood cells associated with hematological disease and paroxysmal nocturnal hemoglobinuria
1) Confidence 0.49 Published 1996 Journal Schweiz Med Wochenschr Section Abstract Doc Link 8946596 Disease Relevance 0.99 Pain Relevance 0
The occurrence of the PIG-A mutation causing the absence of GPI-linked proteins on blood cells allows the PNH clone to flourish and to maintain hematopoiesis; thus it seems that the PIG-A mutation is nature's own gene therapy and the price that these patients have to pay is PNH.
Positive_regulation (causing) of PIG-A in blood cells associated with hematological disease and paroxysmal nocturnal hemoglobinuria
2) Confidence 0.49 Published 1996 Journal Schweiz Med Wochenschr Section Abstract Doc Link 8946596 Disease Relevance 0.99 Pain Relevance 0
The only curative approach for PNH is allogeneic hematopoietic stem cell transplantation (SCT); alternative strategies include cell therapy (insertion of molecules on the outer surface of blood cells) (Hill et al 2006) and gene therapy (insertion of a functional PIG-A gene in early hematopoietic progenitors), but all experimental efforts have so far been unfruitful and seem to be far away from clinical applications.
Positive_regulation (insertion) of PIG-A in blood cells associated with paroxysmal nocturnal hemoglobinuria
3) Confidence 0.49 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 0.85 Pain Relevance 0

General Comments

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