INT6683

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 64
Total Number 65
Disease Relevance 11.31
Pain Relevance 32.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 10
neurons 8
nucleus accumbens 5
brain 4
cerebellum 2
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 639 100.00 Very High Very High Very High
dopamine receptor 214 100.00 Very High Very High Very High
antagonist 82 100.00 Very High Very High Very High
Enkephalin 78 100.00 Very High Very High Very High
agonist 72 100.00 Very High Very High Very High
Inflammation 60 100.00 Very High Very High Very High
substance P 57 100.00 Very High Very High Very High
Glutamate 39 100.00 Very High Very High Very High
Neuropeptide 23 100.00 Very High Very High Very High
Central nervous system 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypothermia 3 99.98 Very High Very High Very High
Alcohol Addiction 248 99.32 Very High Very High Very High
Cerebellar Diseases 15 98.92 Very High Very High Very High
Schizophrenia 15 98.88 Very High Very High Very High
Diabetes Mellitus 453 98.84 Very High Very High Very High
Paralysis 1 98.72 Very High Very High Very High
Ganglion Cysts 19 98.48 Very High Very High Very High
Depression 20 98.44 Very High Very High Very High
Stress 123 98.04 Very High Very High Very High
INFLAMMATION 59 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopamine type 2 receptor expression and function in rodent sensory neurons projecting to the airways.
Gene_expression (expression) of Dopamine type 2 receptor in sensory neurons associated with dopamine
1) Confidence 0.78 Published 2005 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Title Doc Link 15792966 Disease Relevance 0 Pain Relevance 0.70
This DRD2 overexpression similarly produced significant reductions in ethanol non-preferring rats, in both alcohol preference (16%) and alcohol intake (75%).
Gene_expression (overexpression) of DRD2 associated with alcohol
2) Confidence 0.73 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15288384 Disease Relevance 0.22 Pain Relevance 0.68
RESULTS: The main results are the postpubertal onset of increased NR1 mRNA expression in all cortical regions and decreased dopamine D2 receptor, substance P and enkephalin mRNA expression in the striatum only in rats lesioned as neonates.
Gene_expression (expression) of dopamine D2 receptor in striatum
3) Confidence 0.71 Published 2009 Journal Schizophr. Res. Section Body Doc Link 19500946 Disease Relevance 0 Pain Relevance 0
The results indicated that the level of the dopamine D2 receptor transcript was significantly reduced by SP(1-7) in nucleus accumbens and frontal cortex but not altered in the striatum.
Gene_expression (level) of dopamine D2 receptor in nucleus accumbens associated with nucleus accumbens, dopamine, urological neuroanatomy and substance p
4) Confidence 0.65 Published 2003 Journal Peptides Section Abstract Doc Link 12576096 Disease Relevance 0.33 Pain Relevance 1.28
Substance P(1-7) affects the expression of dopamine D2 receptor mRNA in male rat brain during morphine withdrawal.
Gene_expression (expression) of dopamine D2 receptor in brain associated with dopamine, withdrawal, morphine and substance p
5) Confidence 0.65 Published 2003 Journal Peptides Section Title Doc Link 12576096 Disease Relevance 0.14 Pain Relevance 1.20
In this study we have investigated the effect of the heptapeptide fragment on the expression of the brain dopamine D2 receptor mRNA and on the withdrawal reaction, as well, in morphine-dependent rats.
Gene_expression (expression) of dopamine D2 receptor in brain associated with dopamine, withdrawal and morphine
6) Confidence 0.65 Published 2003 Journal Peptides Section Abstract Doc Link 12576096 Disease Relevance 0.10 Pain Relevance 1.11
In view of previous results after 6-hydroxydopamine lesions in adults, it appears that the behavioral differences observed after adult or neonatal 6-hydroxydopamine lesions are accompanied by a similar alteration of GAD67, preproenkephalin and dopamine D2 receptor gene expression in presumed striatal projection neurons.
Gene_expression (expression) of dopamine D2 receptor gene in projection neurons associated with dopamine and projection neuron
7) Confidence 0.65 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.42
The present study demonstrates that bilateral 6-hydroxydopamine lesions of dopamine neurons in neonate rats are able to induce a long-term and widespread alteration in the expression of genes encoding for GAD67, preproenkephalin and dopamine D2 receptor in the striatum.
Gene_expression (expression) of dopamine D2 receptor in dopamine neurons associated with dopamine
8) Confidence 0.65 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.50
The effects of single and repeated cocaine administration on proenkephalin (PENK) and D2 dopamine receptor mRNA expression in the nucleus accumbens and striatum of the rat were studied.
Gene_expression (expression) of D2 dopamine receptor mRNA in striatum associated with nucleus accumbens, dopamine receptor and cocaine
9) Confidence 0.64 Published 1995 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 8998398 Disease Relevance 0 Pain Relevance 0.38
Adaptive changes in the proenkephalin and D2 dopamine receptor mRNA expression after chronic cocaine in the nucleus accumbens and striatum of the rat.
Gene_expression (expression) of D2 dopamine receptor mRNA in nucleus accumbens associated with nucleus accumbens, dopamine receptor, enkephalin and cocaine
10) Confidence 0.64 Published 1995 Journal Eur Neuropsychopharmacol Section Title Doc Link 8998398 Disease Relevance 0 Pain Relevance 0.66
The frequency of the TaqI A(1) allele of the D(2) dopamine receptor (DRD2) gene was 19.0% in these patients compared with 4.6% in controls free of past and current alcohol and other drug abuse and free of family history of alcohol and other drug abuse (p = 0.009).
Gene_expression (frequency) of DRD2 associated with drug abuse, dopamine receptor and alcohol
11) Confidence 0.63 Published 2000 Journal Am. J. Med. Genet. Section Abstract Doc Link 11054765 Disease Relevance 0.34 Pain Relevance 0.79
The present study tested association of three polymorphisms -141C Ins/Del, TaqI B and TaqI A, present at DRD2 gene locus with alcohol dependence in north Indian subjects.
Gene_expression (present) of DRD2 associated with addiction and alcohol
12) Confidence 0.60 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.53 Pain Relevance 0.67
An in vitro analysis suggested that -141C Ins/Del polymorphism of DRD2 alters its transcriptional activity and thus regulates the expression of DRD2 receptor [19].
Gene_expression (expression) of DRD2
13) Confidence 0.60 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.45 Pain Relevance 0.29
Thus, the differential effects of dopamine on striatonigral and striatopallidal neurons are mediated by their specific expression of D1 and D2 dopamine receptor subtypes, respectively.
Gene_expression (expression) of D2 dopamine receptor in neurons associated with dopamine and dopamine receptor
14) Confidence 0.57 Published 1990 Journal Science Section Abstract Doc Link 2147780 Disease Relevance 0.19 Pain Relevance 0.61
Striatopallidal neurons show a 6-OHDA-induced elevation in their specific expression of messenger RNAs (mRNAs) encoding the D2 dopamine receptor and enkephalin, which is reversed by subsequent continuous treatment with the D2 agonist quinpirole.
Gene_expression (expression) of D2 dopamine receptor in neurons associated with dopamine receptor, agonist and enkephalin
15) Confidence 0.57 Published 1990 Journal Science Section Abstract Doc Link 2147780 Disease Relevance 0.26 Pain Relevance 0.63
Our findings of decreased dopamine D2 receptor levels in socially isolated Flinders Sensitive Line rats suggest that low D2 receptor expression may play a role in pathophysiology of depression.
Gene_expression (expression) of D2 receptor associated with dopamine and depression
16) Confidence 0.57 Published 2007 Journal Neuroreport Section Abstract Doc Link 17558292 Disease Relevance 0.18 Pain Relevance 0.56
The effects of neonatal 6-hydroxydopamine injections on the levels and cellular distribution of glutamate decarboxylase (GAD67), preproenkephalin and dopamine D2 receptor messenger RNAs were studied in the striatum of adult rats.
Gene_expression (levels) of dopamine D2 receptor in striatum associated with dopamine and glutamate
17) Confidence 0.57 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.28
We investigated the effect of catecholamine depletion on gene expression for preproenkephalin A (PPA) and D2 dopamine receptor (D2R) in the rat nigrostriatal complex, using quantitative Northern blot analysis.
Gene_expression (expression) of D2 dopamine receptor associated with dopamine receptor and catecholamine
18) Confidence 0.56 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1331675 Disease Relevance 0 Pain Relevance 0.38
Reserpine treatment stimulates enkephalin and D2 dopamine receptor gene expression in the rat striatum.
Gene_expression (expression) of D2 dopamine receptor in striatum associated with dopamine receptor and enkephalin
19) Confidence 0.56 Published 1992 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1331675 Disease Relevance 0 Pain Relevance 0.65
In order to investigate whether early VH lesion in rats alters the expression of genes implicated in schizophrenia pre- and post-puberty, we studied the mRNA expression of neuropeptides (substance P, dynorphin and enkephalin), dopamine D1, dopamine D2, and NMDA (subunits NR1 and NR2A) receptors in this animal model.
Gene_expression (expression) of dopamine D2 associated with dopamine, dynorphin, neuropeptide, enkephalin, hippocampus, schizophrenia and substance p
20) Confidence 0.55 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19500946 Disease Relevance 0.27 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox