INT66852

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Context Info
Confidence 0.14
First Reported 1996
Last Reported 2011
Negated 9
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 9.74
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cell 4
smooth muscle 1
lymphoid tissue 1
spleen 1
follicular dendritic cells 1
Fcer2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
abdominal pain 27 91.76 High High
Inflammation 10 88.48 High High
Pain 8 87.44 High High
fibrosis 14 85.68 High High
vincristine 7 81.76 Quite High
alcohol 1 78.92 Quite High
imagery 25 77.44 Quite High
Bile 5 75.36 Quite High
cva 11 72.20 Quite High
shoulder pain 1 62.16 Quite High
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 28 99.04 Very High Very High Very High
Cancer 44 98.96 Very High Very High Very High
Chronic Lymphoid Leukemia 24 98.60 Very High Very High Very High
Disease 67 97.92 Very High Very High Very High
Hyperplasia 7 97.12 Very High Very High Very High
Splenomegaly 11 95.56 Very High Very High Very High
Sarcoma 25 95.52 Very High Very High Very High
Lymphoproliferative Disease 4 94.88 High High
Lymphatic System Cancer 116 94.28 High High
Malignant Neoplastic Disease 27 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunologically, the tumor cells showed a close resemblance to the normal follicular dendritic cells with consistent expression of CD21 [C3d complement receptor] (Figure 2) and CD23 (Figure 3).
Gene_expression (expression) of CD23 in follicular dendritic cells associated with cancer
1) Confidence 0.14 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2556649 Disease Relevance 0.66 Pain Relevance 0
CD23 was negative.


Neg (negative) Gene_expression (negative) of CD23
2) Confidence 0.10 Published 2010 Journal Cases J Section Body Doc Link PMC2845114 Disease Relevance 0.58 Pain Relevance 0
Immunophenotyping revealed a clonal B-cell population coexpressing CD5, CD19, and CD20 with weak CD23 and CD25 and very weak, restricted, surface lambda.
Gene_expression (coexpressing) of CD23 in B-cell
3) Confidence 0.08 Published 2003 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 12810261 Disease Relevance 0.43 Pain Relevance 0.09
Immunophenotypic study of these lymphocytes was positive for CD19, CD20 and CD22 while being negative for CD5, CD10, CD23, CD25, CD11c and FMC7, the phenotype belonging to the lymphocytes of marginal spleen zone.
Neg (negative) Gene_expression (negative) of CD23 in spleen
4) Confidence 0.08 Published 1996 Journal Med Clin (Barc) Section Abstract Doc Link 8948931 Disease Relevance 0.90 Pain Relevance 0.11
Immunohistochemistry of the tumour showed smooth muscle actin (SMA) to be focally positive, but Desmin, CD34, S-100, Neurofilament, EMA, CAM 5.2, CD117, CD21 and CD23 were negative.
Neg (negative) Gene_expression (negative) of CD23 in smooth muscle associated with cancer
5) Confidence 0.06 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1513591 Disease Relevance 1.50 Pain Relevance 0.11
The histo morphology and the immunophenotypic analysis were consistent with a mantle cell lymphoma – positive for Cyclin D1, CD20, CD79a and CD5; negative for BCL16, CD23 and CD10.
Neg (negative) Gene_expression (negative) of CD23 associated with mantle-cell lymphoma
6) Confidence 0.06 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2732623 Disease Relevance 1.20 Pain Relevance 0
CD5, CD10, CD23 and bcl-6 markers were found negative.
Neg (negative) Gene_expression (negative) of CD23
7) Confidence 0.06 Published 2010 Journal Cases J Section Body Doc Link PMC2828431 Disease Relevance 0.64 Pain Relevance 0.04
Staining for CD2, CD3, CD5, CD7, CD20, CD23, CD33, CD14, CD15, AC133 and KOR-SA3544 was negative.
Neg (negative) Gene_expression (negative) of CD23
8) Confidence 0.05 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 15053308 Disease Relevance 0.57 Pain Relevance 0.08
Pathology on duodenal biopsies revealed marked expansion of atypical lymphoid tissue, positive staining for CD20, BCL-6, BCL-2, CD10, and KI-67 and negative for CD5, CD23, Tdt, BCL-1, and CD30. cMYC translocation was negative and there was a light chain but not heavy chain rearrangement present.
Neg (negative) Gene_expression (negative) of CD23 in lymphoid tissue
9) Confidence 0.05 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 0.71 Pain Relevance 0.41
B-cells expressed CD5, CD19, CD20, CD21 (partial), CD22, CD23, CD11c (partial) and CD52, consistent with CLL.
Gene_expression (expressed) of CD23 in B-cells associated with chronic lymphoid leukemia
10) Confidence 0.04 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2923171 Disease Relevance 0.35 Pain Relevance 0.04
Flowcytometric analysis revealed a B cell population expressing CD19, CD20, CD22, HLA-DR and kappa, but negative for CD5, CD10, CD23, and CD34, and tdT.
Neg (negative) Gene_expression (negative) of CD23 in B cell
11) Confidence 0.03 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.02 Pain Relevance 0.19
Flowcytometric analysis revealed a B cell population expressing CD19, CD20, CD22, HLA-DR and kappa, but negative for CD5, CD10, CD23, and CD34, and tdT.
Neg (negative) Gene_expression (expressing) of CD23 in B cell
12) Confidence 0.03 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.09 Pain Relevance 0.20
Decreased FcalphaR expression represents a new marker for this disease.


Gene_expression (expression) of FcalphaR
13) Confidence 0.01 Published 2000 Journal J. Rheumatol. Section Body Doc Link 10685807 Disease Relevance 0 Pain Relevance 0
CONCLUSION: We observed impaired expression of FcalphaR in patients with AS that is characterized by a downregulation process associated with post-translational alterations and enhanced binding of endogenous IgA.
Gene_expression (expression) of FcalphaR
14) Confidence 0.01 Published 2000 Journal J. Rheumatol. Section Body Doc Link 10685807 Disease Relevance 0 Pain Relevance 0
Cell surface FcalphaR was analyzed using a quantitative flow cytometry method in which blood cells were stained with anti-FcalphaR monoclonal antibodies recognizing epitopes outside the IgA binding site and with F(ab')2 fragments of anti-IgA antibodies.
Gene_expression (stained) of FcalphaR in blood cells
15) Confidence 0.01 Published 2000 Journal J. Rheumatol. Section Body Doc Link 10685807 Disease Relevance 0.09 Pain Relevance 0

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