INT66857

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Context Info
Confidence 0.53
First Reported 1996
Last Reported 2011
Negated 5
Speculated 3
Reported most in Abstract
Documents 39
Total Number 42
Disease Relevance 28.55
Pain Relevance 18.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocyte 13
plasma 3
smooth muscle cells 2
T cell 2
aorta 1
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 329 100.00 Very High Very High Very High
chemokine 326 100.00 Very High Very High Very High
cytokine 256 100.00 Very High Very High Very High
Inflammatory mediators 10 100.00 Very High Very High Very High
lidocaine 6 100.00 Very High Very High Very High
alcohol 4 99.98 Very High Very High Very High
opioid receptor 21 99.90 Very High Very High Very High
Chronic pancreatitis 2 99.84 Very High Very High Very High
Morphine 65 99.72 Very High Very High Very High
endometriosis 210 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 357 100.00 Very High Very High Very High
Cancer 111 100.00 Very High Very High Very High
Necrosis 19 100.00 Very High Very High Very High
Toxicity 10 99.92 Very High Very High Very High
Acute Coronary Syndrome 150 99.84 Very High Very High Very High
Pancreatitis 3 99.84 Very High Very High Very High
Disorders Of Creatine Metabolism 10 99.58 Very High Very High Very High
Pre-eclampsia 6 99.24 Very High Very High Very High
Endometriosis 243 99.16 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 86 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that DAMGO administration induces a significant increase in RANTES and IP-10 expression, while MCP-1 protein levels remain unaffected in PBMCs infected with the HIV-1 strain.
Neg (unaffected) Regulation (unaffected) of MCP-1 associated with acquired immune deficiency syndrome or hiv infection and sprains and strains
1) Confidence 0.53 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11086093 Disease Relevance 1.03 Pain Relevance 0.89
circulating MCP-1 concentrations in preeclampsia.
Regulation (circulating) of MCP-1 associated with pre-eclampsia
2) Confidence 0.45 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.36 Pain Relevance 0
Combined with our results, the data indicate that the major three factors (IL-6, IL-8 and MCP-1) are critical in multiple vitreoretinal disorders including uveitis.
Regulation (critical) of MCP-1 associated with uveitis
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 1.53 Pain Relevance 0.06
However, they found as did we, that exposure of astrocytes to morphine alone had no significant effect on CCL2 production [25].
Neg (no) Regulation (effect) of CCL2 in astrocytes associated with morphine
4) Confidence 0.39 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.09 Pain Relevance 1.18
RESULTS: Production of interleukin (IL)-8, growth-related oncogene (GRO)-alpha, monocyte chemoattractant protein (MCP)-1, and regulated upon activation normal T-cell expressed and secreted (RANTES) protein by synovial fibroblasts was increased by TNF-alpha.
Regulation (regulated) of monocyte chemoattractant protein in monocyte
5) Confidence 0.39 Published 2005 Journal J. Oral Pathol. Med. Section Body Doc Link 15946184 Disease Relevance 0.18 Pain Relevance 0
To investigate the possible involvement of MCAF/MCP-1 in the pathogenesis, its course was studied in patients with acute myocardial infarction.
Spec (possible) Regulation (involvement) of MCAF associated with myocardial infarction
6) Confidence 0.34 Published 1997 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9040055 Disease Relevance 0.85 Pain Relevance 0.27
Furthermore, this inhibition was either as effective, or for ICAM-1, MCP-1, GROalpha, and NAP-2, more effective, than a maximally effective concentration of dexamethasone.
Regulation (effective) of MCP-1 associated with dexamethasone
7) Confidence 0.31 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 0.39 Pain Relevance 0.41
Moreover, astrocyte cultures treated with morphine and Tat showed exaggerated increases in chemokine release, including monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), as well as interleukin-6 (IL-6).
Regulation (regulated) of MCP-1 in T cell associated with chemokine and morphine
8) Confidence 0.31 Published 2005 Journal Glia Section Abstract Doc Link 15630704 Disease Relevance 0.87 Pain Relevance 1.05
Moreover, astrocyte cultures treated with morphine and Tat showed exaggerated increases in chemokine release, including monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), as well as interleukin-6 (IL-6).
Regulation (regulated) of monocyte chemoattractant protein-1 in T cell associated with chemokine and morphine
9) Confidence 0.31 Published 2005 Journal Glia Section Abstract Doc Link 15630704 Disease Relevance 0.89 Pain Relevance 1.06
Changes in CCR2 chemokine receptor expression and plasma MCP-1 concentration after the implantation of bare metal stents versus sirolimus-eluting stents in patients with stable angina.
Regulation (Changes) of MCP-1 in plasma associated with chemokine and angina
10) Confidence 0.28 Published 2008 Journal Intern. Med. Section Title Doc Link 18175998 Disease Relevance 0.28 Pain Relevance 0.19
In this study, we examined the effect of lidocaine on lipopolysaccharide-stimulated MCP-1 secretion and MCP-1 induced chemotaxis in a human monocytic cell line, THP-1.
Spec (examined) Regulation (effect) of MCP-1 in THP-1 associated with lidocaine
11) Confidence 0.27 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.39 Pain Relevance 0.68
not prove to have a significant effect on circulating MCP-1 concentrations in
Regulation (effect) of MCP-1
12) Confidence 0.27 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.06 Pain Relevance 0
Glia displayed increased MOR and MCP-1 immunoreactivity after morphine and/or Tat exposure.
Regulation (immunoreactivity) of MCP-1 associated with opioid receptor and morphine
13) Confidence 0.27 Published 2006 Journal Glia Section Abstract Doc Link 16206161 Disease Relevance 0.39 Pain Relevance 1.09
In the present study we report the expression pattern of the chemokines interferon-gamma-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and regulated upon activation normal T cell expressed and secreted (RANTES) in sciatic nerves from animals with myelin-induced experimental autoimmune neuritis, using a semiquantitative reverse transcriptase-PCR dot-blot hybridization assay.
Regulation (regulated) of MCP in sciatic nerves associated with chemokine, inflammation, experimental autoimmune neuritis, sciatic nerve and neuritis
14) Confidence 0.26 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.74 Pain Relevance 0.60
Because a QTL for MCP-1 in the Framingham Heart Study overlaps with the GENECARD ACS linkage peak, we also tested the effect of rs10920501 on MCP-1 expression levels in the aorta, but found no evidence for any relationship (data not shown).


Regulation (effect) of MCP-1 in aorta associated with acute coronary syndrome
15) Confidence 0.24 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.26 Pain Relevance 0
Moreover, previous work has established that monocyte chemokines such as monocyte chemoattractant protein-1 (MCP-1) are prognostic in ACS [5].
Regulation (prognostic) of MCP-1 in monocyte associated with chemokine and acute coronary syndrome
16) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518836 Disease Relevance 1.35 Pain Relevance 0.49
Moreover, previous work has established that monocyte chemokines such as monocyte chemoattractant protein-1 (MCP-1) are prognostic in ACS [5].
Regulation (prognostic) of monocyte chemoattractant protein-1 in monocyte associated with chemokine and acute coronary syndrome
17) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518836 Disease Relevance 1.37 Pain Relevance 0.50
Serial changes of plasma MCP-1 levels were plotted as percent changes from the initial levels (mean +/- SE, %) and were significantly higher in the R group than in the N group at 48 h and at 6 months post stent implantation (104.6+/-4.8 vs 89.2+/-3.4, p<0.01, 109.6+/-11.2 vs 98.5+/-5.0, p<0.05).
Regulation (changes) of MCP-1 in plasma
18) Confidence 0.19 Published 2001 Journal Jpn. Circ. J. Section Abstract Doc Link 11316119 Disease Relevance 0.75 Pain Relevance 0.38
In this study, the authors investigated whether eotaxin and MCP-1 expression and release in human airway smooth muscle cells could be modulated by an increase in intracellular cyclic adenosine monophosphate (cAMP) concentration.
Regulation (modulated) of MCP-1 in smooth muscle cells associated with adenocard
19) Confidence 0.18 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0.28 Pain Relevance 0.22
In addition, plasma levels of MCP-1 are affected by a polymorphism in the MCP-1 gene [27].
Regulation (affected) of MCP-1 in plasma
20) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766003 Disease Relevance 1.50 Pain Relevance 0.62

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