INT66867

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 58
Total Number 60
Disease Relevance 30.44
Pain Relevance 40.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ceacam3) cellular_component (Ceacam3) biological_process (Ceacam3)
Anatomy Link Frequency
CeA 15
neurons 4
visceral 3
brain 2
synapses 2
Ceacam3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 2709 100.00 Very High Very High Very High
Central grey 627 100.00 Very High Very High Very High
nMDA receptor 182 100.00 Very High Very High Very High
projection neuron 23 100.00 Very High Very High Very High
Nucleus accumbens 20 100.00 Very High Very High Very High
Periaqueductal grey 6 99.84 Very High Very High Very High
hypoalgesia 1 99.84 Very High Very High Very High
Dopamine 414 99.76 Very High Very High Very High
Delta opioid receptors 9 99.76 Very High Very High Very High
Enkephalin 27 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 700 100.00 Very High Very High Very High
Hypoalagesia 1 99.84 Very High Very High Very High
Aids-related Complex 63 99.72 Very High Very High Very High
Arthritis 227 99.66 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

50 99.52 Very High Very High Very High
Convulsion 4 99.50 Very High Very High Very High
Stress 897 99.48 Very High Very High Very High
Anxiety Disorder 874 99.44 Very High Very High Very High
Shock 817 99.24 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

120 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a related CeA function is the expression of hypoalgesia induced by conditioned stimuli or systemic morphine administration, we examined postsynaptic opioid modulation of neurons in each major CeA subdivision.
Gene_expression (expression) of CeA in CeA associated with hypoalgesia, opioid, amygdala and morphine
1) Confidence 0.67 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16802333 Disease Relevance 0.20 Pain Relevance 0.77
Prodynorphin was not expressed by calbindin neurons in the medial part of the lateral CeA, and indirect evidence suggested that it was not expressed by enkephalin neurons.
Neg (not) Gene_expression (expressed) of CeA in neurons associated with enkephalin and amygdala
2) Confidence 0.65 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17722034 Disease Relevance 0 Pain Relevance 1.11
Preliminary studies with microdialysis and real-time PCR analysis support this idea: local ethanol administration in vivo had no effect on glutamate release, but chronic ethanol nearly tripled the expression of NR2B subunits (the most ethanol sensitive) in CeA.
Gene_expression (expression) of CeA in CeA associated with glutamate and amygdala
3) Confidence 0.63 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14684447 Disease Relevance 0.07 Pain Relevance 0.98
There are high densities of galanin and galanin receptors found in the CeA.
Gene_expression (found) of CeA in CeA associated with amygdala
4) Confidence 0.63 Published 2010 Journal Brain Res. Section Abstract Doc Link 20051236 Disease Relevance 0.10 Pain Relevance 0.92
We speculate that the decreased CRF expression in the CeA of anesthetized rats is related to the reduction of cortical activity caused by general anesthesia, which disrupts the relay of pain-related information from the neocortex to the amygdala.
Gene_expression (expression) of CeA in amygdala associated with pain, anesthesia and amygdala
5) Confidence 0.60 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.38 Pain Relevance 1.16
The main result of this study is that the expression of CRF and pERK in the CeA was significantly increased by CRD-induced visceral pain, and that this effect was attenuated by general anesthesia, whereas the expression of c-Fos in the spinal cord was unaffected by general anesthesia.
Gene_expression (expression) of CeA in visceral associated with anesthesia, visceral pain, amygdala and spinal cord
6) Confidence 0.60 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.14 Pain Relevance 0.86
Anxiety-like behavior was measured in 5 groups of rats to determine the role of CRF1 receptors: arthritic rats without any additional intervention; arthritic rats that received systemic administration of vehicle (saline); arthritic rats with systemic administration of NBI27014 (5 mg/kg, i.p.); arthritic rats with vehicle (ACSF) administration into the CeA; and arthritic rats with intra-CeA administration of NBI27014 (100 ?
Gene_expression (administration) of CeA associated with anxiety disorder, amygdala and arthritis
7) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC1891279 Disease Relevance 0.80 Pain Relevance 0.34
Coexpression of prodynorphin in extrahypothalamic CRH neurons in the CeA could provide an anatomical basis for regulation of the stress responses and other CRH-related functions by the brain dynorphin/KOP receptor system.
Gene_expression (Coexpression) of CeA in neurons associated with stress, dynorphin, opioid and amygdala
8) Confidence 0.58 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17722034 Disease Relevance 0.10 Pain Relevance 1.08
About one-third of the prodynorphin neurons in the CeA coexpressed CRH, whereas no coexpression with CRH was detected in the BST.
Gene_expression (coexpressed) of CeA in CeA associated with amygdala
9) Confidence 0.58 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17722034 Disease Relevance 0 Pain Relevance 1.10
The present study investigated the effects of intra-CeA PACAP microinjection on behavioral responses using the shock-probe fear

(defensive burying) test.

Gene_expression (microinjection) of CeA in CeA associated with anxiety disorder, shock and amygdala
10) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.56 Pain Relevance 0.31
No intra-CeA PACAP injection effects were found in animals tested with the
Gene_expression (injection) of CeA associated with amygdala
11) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.46 Pain Relevance 0.34
Likewise, the behavioral pharmacologic effects observed in the current study most likely reflect PACAP's actions on several classes of CeA neurons that may be interneurons and/or
Gene_expression (neurons) of CeA in interneurons associated with amygdala
12) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.21 Pain Relevance 0.73
substantial effects of PACAP microinjection into the CeA on the expression of
Gene_expression (microinjection) of CeA associated with amygdala
13) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.70 Pain Relevance 0.35
velocity of movement were reduced in intra-CeA PACAP-injected animals tested
Gene_expression (injected) of CeA associated with amygdala
14) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 1.22 Pain Relevance 0.37
To determine whether intra-CeA infusion of PACAP, without shocks, would produce alterations in behaviors, a group of rats was subjected to intra-CeA aCSF or PACAP injections and 20-minute exposure to the test chamber in the presence of an unelectrified probe.
Gene_expression (injections) of CeA associated with shock and amygdala
15) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.66 Pain Relevance 0.10
Intra-CeA PACAP infusion reduces number of shocks without
Gene_expression (infusion) of CeA associated with shock and amygdala
16) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.50 Pain Relevance 0.28
Infusion of PACAP into CeA resulted in no
Gene_expression (Infusion) of CeA associated with amygdala
17) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.75 Pain Relevance 0.33
In the current study, intra-CeA PACAP injection produced a significant increase in the withdrawal of the shocked rats away from the electrified probe, resulting in dramatically reduced numbers of contact induced shocks.
Gene_expression (injection) of CeA associated with shock, withdrawal and amygdala
18) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 1.10 Pain Relevance 0.28
Intra-CeA PACAP injection does not alter exploration of the
Gene_expression (injection) of CeA associated with amygdala
19) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.50 Pain Relevance 0.34
stimulation inhibits CeA output neurons (Quirk et al. [53]), and that excitotoxic lesions of the mPFC or its pharmacologic inactivation with muscimol potently inhibit fear, specifically reducing active stress coping such as shock-probe burying (Shah and Treit [54];
Gene_expression (output neurons) of CeA in output neurons associated with stress, shock, anxiety disorder and amygdala
20) Confidence 0.57 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.65 Pain Relevance 0.27

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