INT66868

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 26.61
Pain Relevance 28.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ceacam3) cellular_component (Ceacam3) biological_process (Ceacam3)
Anatomy Link Frequency
CeA 15
visceral 4
neurons 3
CeA 2
interneurons 1
Ceacam3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 1160 100.00 Very High Very High Very High
Central grey 621 100.00 Very High Very High Very High
antagonist 68 100.00 Very High Very High Very High
Glutamate 66 100.00 Very High Very High Very High
Opioid 9 100.00 Very High Very High Very High
fluoxetine 21 99.98 Very High Very High Very High
narcan 16 99.98 Very High Very High Very High
agonist 21 99.96 Very High Very High Very High
Dopamine 49 99.84 Very High Very High Very High
Visceral pain 33 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1105 100.00 Very High Very High Very High
Urological Neuroanatomy 678 100.00 Very High Very High Very High
Appetite Loss 2 100.00 Very High Very High Very High
Convulsion 14 99.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

33 99.84 Very High Very High Very High
Stomach Cancer 4 99.70 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

132 99.46 Very High Very High Very High
Arthritis 81 99.40 Very High Very High Very High
Pain 154 99.32 Very High Very High Very High
Pancreatic Cancer 5 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: These results suggest that the activation of the noradrenergic system within the CeA contributes to naloxone-precipitated morphine withdrawal-induced CPA, rather than somatic signs, through beta(1)- and beta(2)-adrenoceptors.


Positive_regulation (activation) of CeA in CPA
1) Confidence 0.69 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12768272 Disease Relevance 0 Pain Relevance 0
RESULTS: The extracellular noradrenaline level within the CeA was transiently elevated during morphine withdrawal.
Positive_regulation (elevated) of CeA in CeA
2) Confidence 0.69 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12768272 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVES: The aim of the current study was to investigate the hypothesis that acute systemic ethanol administration will increase the release of endogenous opioid peptides at the level of the CeA in a time- and dose-dependent manner.
Positive_regulation (increase) of CeA in CeA
3) Confidence 0.68 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18688603 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Acute systemic ethanol administration induced a dose- and time-dependent increase in beta-endorphin and dynorphin A1-8 release at the level of the CeA, which may be involved in ethanol consumption.


Positive_regulation (increase) of CeA in CeA
4) Confidence 0.68 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18688603 Disease Relevance 0 Pain Relevance 0
Recently, we reported that intraplantar (i.pl.) injection of formalin as a chemical somatic noxious stimulus increased c-fos mRNA expression in the BLA, but not CeA, while intraperitoneal (i.p.) injection of acetic acid as a chemical visceral noxious stimulus induced it highly in the CeA, and hardly in BLA [Nakagawa et al. (2003) Neurosci.
Neg (not) Positive_regulation (increased) of CeA in visceral
5) Confidence 0.65 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622196 Disease Relevance 0.23 Pain Relevance 0.31
Activation of the CeA may be linked with the augmentation of passive behavioral coping (Roozendaal et al. [42]) and potentiated startle reflex as well as post-stress freezing (Tinsley and Fanselow [43]).
Positive_regulation (Activation) of CeA associated with stress and amygdala
6) Confidence 0.59 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.41 Pain Relevance 0.52
We conclude that potentiation of the PB-CeA synapse is consolidated in long-lasting neuropathic pain but that this potentiation results from a molecular mechanism distinct from that in arthritic and visceral pain.
Positive_regulation (potentiation) of CeA in visceral associated with visceral pain, neuropathic pain, amygdala and arthritis
7) Confidence 0.50 Published 2007 Journal Pain Section Abstract Doc Link 17055162 Disease Relevance 0.77 Pain Relevance 1.15
Type A neurons were further classified as either A1 or A2, based on differences in resting membrane potential and the amplitude of after-hyperpolarizing potential. micro-Opioid receptor agonists hyperpolarized a subpopulation of CeA neurons, of which the vast majority was type A1.
Positive_regulation (subpopulation) of CeA in neurons associated with agonist, opioid receptor and amygdala
8) Confidence 0.47 Published 2004 Journal Neuroscience Section Abstract Doc Link 15312899 Disease Relevance 0.20 Pain Relevance 1.21
In our results, CRD caused immediate neuronal activation in the CeA as indicated by the increased expression of p-ERK.
Positive_regulation (activation) of CeA in neuronal associated with amygdala
9) Confidence 0.44 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.44 Pain Relevance 1.01
Calcitonin gene-related peptide (CGRP)-like immunoreactive fibers and CGRP receptors are distributed densely in CeA.
Positive_regulation (distributed) of CeA in CeA associated with amygdala and calcitonin gene-related peptide
10) Confidence 0.44 Published 2003 Journal Neuroscience Section Abstract Doc Link 12732246 Disease Relevance 0.27 Pain Relevance 1.44
Recently, we reported that intraplantar (i.pl.) injection of formalin as a chemical somatic noxious stimulus increased c-fos mRNA expression in the BLA, but not CeA, while intraperitoneal (i.p.) injection of acetic acid as a chemical visceral noxious stimulus induced it highly in the CeA, and hardly in BLA [Nakagawa et al. (2003) Neurosci.
Positive_regulation (induced) of CeA in visceral
11) Confidence 0.44 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622196 Disease Relevance 0.23 Pain Relevance 0.31
spent in the away zone were markedly elevated in CeA-PACAP-injected animals.
Positive_regulation (elevated) of CeA associated with amygdala
12) Confidence 0.42 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 1.01 Pain Relevance 0.33
General anesthesia attenuated the increase in CRF and p-ERK in the CeA, but did not affect the expression of spinal c-Fos.
Positive_regulation (increase) of CeA in CeA associated with anesthesia and amygdala
13) Confidence 0.41 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2967003 Disease Relevance 0.31 Pain Relevance 0.77
Tyr-D-Ala-Gly-(me) Phe-Gly-ol (DAMGO), a micro-opioid receptor agonist, increases food intake, while opioid antagonists, like naltrexone (NTX), inhibit food intake after injection into many brain sites involved in appetite regulation, including the CeA.
Positive_regulation (increases) of CeA in CeA associated with appetite loss, antagonist, agonist, opioid receptor, amygdala and opioid
14) Confidence 0.41 Published 2009 Journal Physiol. Behav. Section Abstract Doc Link 19136019 Disease Relevance 0.17 Pain Relevance 0.80
All sensitizing pretreatments increased GAD67 mRNA in the CeA.
Positive_regulation (increased) of CeA in CeA associated with amygdala
15) Confidence 0.40 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18312583 Disease Relevance 0.47 Pain Relevance 0.68
The presumed PACAP-induced increase in the activity of the CeA may override the influence of the mPFC (decision-making) process, in favor of the more instinctual immobility responses to shock.
Positive_regulation (increase) of CeA associated with shock and amygdala
16) Confidence 0.39 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.67 Pain Relevance 0.32
Moreover, intra-CeA injection of either selective mu-opioid receptor antagonist beta-funaltrexamine (beta-FNA) or delta-opioid receptor antagonist naltrindole, but not kappa-opioid receptor antagonist nor-binaltorphimine (nor-BNI), significantly attenuated the galanin-induced increases in HWLs in the CeA of rats.
Neg (nor) Positive_regulation (increases) of CeA in CeA associated with antagonist, kappa opioid receptor, opioid receptor and amygdala
17) Confidence 0.38 Published 2010 Journal Brain Res. Section Abstract Doc Link 20051236 Disease Relevance 0.06 Pain Relevance 1.50
Our results demonstrate that the level of consciousness may affect the expression of CRF and pERK in the CeA induced by visceral pain.
Positive_regulation (induced) of CeA in visceral associated with visceral pain and amygdala
18) Confidence 0.36 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.30 Pain Relevance 1.23
In contrast, chronic administration of clinically effective antidepressants from four different classes, ie fluoxetine, reboxetine, tranylcypromine, and electroconvulsive seizures (ECS) upregulated Bcl-2 mRNA expression in the Cg, Fr, and CeA.
Positive_regulation (upregulated) of CeA in CeA associated with antidepressant, convulsion, amygdala and fluoxetine
19) Confidence 0.36 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 1.05 Pain Relevance 0.67
The results are consistent with reports in the literature that glutamatergic projections from the BLA do not only reach the CeA directly but also target a cluster of GABAergic interneurons in the ITC that are interposed between BLA and CeA [2,18,35,45,46].
Positive_regulation (reach) of CeA in interneurons associated with gabaergic and amygdala
20) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.26 Pain Relevance 0.81

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