INT66881

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.99
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sort1) endosome (Sort1) transport (Sort1)
Golgi apparatus (Sort1) endoplasmic reticulum (Sort1) intracellular (Sort1)
Anatomy Link Frequency
spinal 1
nerve 1
Sort1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2 100.00 Very High Very High Very High
Analgesic 26 99.32 Very High Very High Very High
antinociception 16 98.44 Very High Very High Very High
Sciatic nerve 3 97.80 Very High Very High Very High
agonist 92 97.16 Very High Very High Very High
interneuron 2 92.20 High High
Dorsal horn 23 90.88 High High
medulla 6 88.48 High High
Antinociceptive 20 86.88 High High
opioid receptor 2 85.76 High High
Disease Link Frequency Relevance Heat
Nociception 90 86.80 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 82.28 Quite High
Pain 122 75.76 Quite High
Low Back Pain 4 75.48 Quite High
Nervous System Injury 1 75.00 Quite High
Injury 9 69.92 Quite High
Inflammatory Pain 8 65.84 Quite High
INFLAMMATION 30 5.00 Very Low Very Low Very Low
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, there is now evidence that the analgesic action of NT is mediated through activation of both G-protein coupled receptors, NTS1 and NTS2 [1,10-12].
Positive_regulation (activation) of NTS1 associated with analgesic
1) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.08 Pain Relevance 0.75
However, since non-discriminative agonists reversed supraspinal nocifensive behaviors, the antinociception observed could also rely on the inhibition of the spino-bulbo-spinal loop by NTS1 receptor activation.
Positive_regulation (activation) of NTS1 in spinal associated with antinociception and agonist
2) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.63 Pain Relevance 0.99
COS 8 augmented the increase of nerve growth factor, brain-derived neurotrophic factor, and NT-3 mRNA expression in the distal stump of the axotomized sciatic nerve.
Positive_regulation (increase) of NT-3 in nerve associated with nerve growth factor and sciatic nerve
3) Confidence 0.21 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8951669 Disease Relevance 0.14 Pain Relevance 0.42

General Comments

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