INT66903

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Context Info
Confidence 0.25
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Nox1) signal transduction (Nox1) transport (Nox1)
oxidoreductase activity (Nox1) plasma membrane (Nox1) extracellular matrix organization (Nox1)
Anatomy Link Frequency
plasma 2
Nox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 86 90.20 High High
Hippocampus 17 88.96 High High
Pyramidal cell 3 83.84 Quite High
qutenza 2 78.24 Quite High
cerebral cortex 2 77.12 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 99.68 Very High Very High Very High
Cv General 4 Under Development 55 90.20 High High
Death 19 88.20 High High
Cv Unclassified Under Development 30 84.72 Quite High
Stress 26 80.80 Quite High
Targeted Disruption 2 68.08 Quite High
Hepatocellular Cancer 1 64.08 Quite High
Cognitive Disorder 12 50.00 Quite Low
Pressure And Volume Under Development 1 43.68 Quite Low
Brain Hemorrhage 1 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rac1 GTPase may also be involved in activation of NOX1 and NOX3 isoforms, but it does not appear to be involved in activation of the NOX4, NOX 5 or Duox isoforms [30].
Positive_regulation (activation) of NOX1
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.85 Pain Relevance 0.48
We report here that ubiquinone analogues that contain a short, less hydrophobic side chain than coenzyme Q-10 dramatically stimulate the NADH-oxidase activity of isolated rat liver plasma membranes whereas they show no effect on the reductase activity of isolated membranes.
Positive_regulation (stimulate) of NADH-oxidase in plasma
2) Confidence 0.20 Published 1996 Journal J. Bioenerg. Biomembr. Section Abstract Doc Link 8953385 Disease Relevance 0 Pain Relevance 0.06
Is the drug-responsive NADH oxidase of the cancer cell plasma membrane a molecular target for adriamycin?
Positive_regulation (drug-responsive) of NADH oxidase in plasma associated with cancer
3) Confidence 0.15 Published 1997 Journal J. Bioenerg. Biomembr. Section Title Doc Link 9298712 Disease Relevance 0.25 Pain Relevance 0.08

General Comments

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