INT66907

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.18
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b, Oxt) extracellular region (Il1b, Oxt) aging (Il1b)
response to stress (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
blood 2
supraoptic nucleus 2
Il1b (Rattus norvegicus)
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 4 96.32 Very High Very High Very High
narcan 14 96.12 Very High Very High Very High
medulla 2 90.40 High High
cytokine 2 85.08 High High
antagonist 2 79.76 Quite High
Opioid 4 79.32 Quite High
noradrenaline 1 75.00 Quite High
depression 2 25.00 Low Low
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 1 98.48 Very High Very High Very High
Infection 2 86.32 High High
Depression 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, systemic IL-1beta acts centrally to increase oxytocin secretion.
IL-1beta Positive_regulation (increase) of Localization (secretion) of oxytocin
1) Confidence 0.78 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553786 Disease Relevance 0 Pain Relevance 0.65
In virgin Sprague-Dawley rats, IL-1beta (500 ng/kg i.v.) rapidly increased oxytocin secretion (3.2-fold), via a central action as the firing rate of oxytocin neurons in the supraoptic nucleus was increased.
IL-1beta Positive_regulation (increased) of Localization (secretion) of oxytocin in supraoptic nucleus
2) Confidence 0.56 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553786 Disease Relevance 0.09 Pain Relevance 0.43
Interleukin-1 beta stimulates oxytocin and vasopressin release in conscious, male rats and causes a rise in blood pressure.
Interleukin-1 beta Positive_regulation (stimulates) of Localization (release) of oxytocin in blood associated with pressure and volume under development
3) Confidence 0.08 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8953469 Disease Relevance 0.10 Pain Relevance 0.04

General Comments

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