INT66917

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HSF1) nucleus (HSF1) protein complex (HSF1)
cytoplasm (HSF1)
Anatomy Link Frequency
HSF 1
HSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 100.00 Very High Very High Very High
Inflammatory stimuli 2 99.68 Very High Very High Very High
Inflammation 2 98.76 Very High Very High Very High
addiction 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 100.00 Very High Very High Very High
Shock 27 96.24 Very High Very High Very High
Repression 1 95.52 Very High Very High Very High
Stress 20 94.96 High High
Toxicity 4 56.80 Quite High
Apoptosis 11 55.76 Quite High
Death 9 39.04 Quite Low
Cancer 9 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HSF-1 was activated in these cells by a wide range of classes of non-steroidal antiinflammatory drugs (NSAIDs) while being strongly repressed by pro-inflammatory stimuli.
Negative_regulation (repressed) of HSF-1 in HSF associated with inflammation, cinod and inflammatory stimuli
1) Confidence 0.43 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8954923 Disease Relevance 0.80 Pain Relevance 0.40
To assess the importance of the heat shock response in mediating the cellular response to electrophile stress, siRNA was used to silence HSF1, thereby attenuating heat shock gene expression in HNE-treated cells.(27) Control and HSF1-deficient cells were then exposed to HNE, and various responses measured including viability and gene expression changes. siRNA knockdown of HSF1 was nearly complete, and residual expression of the transcription factor was vanishingly small.
Negative_regulation (knockdown) of HSF1 associated with stress and shock
2) Confidence 0.36 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.52 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox