INT66918

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.18
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HSF1) nucleus (HSF1) protein complex (HSF1)
cytoplasm (HSF1)
Anatomy Link Frequency
HeLa 3
monocytes 1
spinal cord neurons 1
HSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 100.00 Very High Very High Very High
Inflammatory stimuli 2 100.00 Very High Very High Very High
Spinal cord 84 99.76 Very High Very High Very High
Inflammation 1 91.00 High High
Immobilon 14 5.00 Very Low Very Low Very Low
Glutamate 14 5.00 Very Low Very Low Very Low
ischemia 7 5.00 Very Low Very Low Very Low
Bioavailability 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 7 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 481 100.00 Very High Very High Very High
INFLAMMATION 14 100.00 Very High Very High Very High
Stress 131 98.08 Very High Very High Very High
Colon Cancer 51 95.72 Very High Very High Very High
Cytomegalovirus Infection 14 94.20 High High
Repression 1 94.16 High High
Targeted Disruption 38 80.04 Quite High
Cancer 86 67.76 Quite High
Neurodegenerative Disease 14 56.64 Quite High
Apoptosis 6 56.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the wealth of literature information on the regulation and function of HSF1 and the robust transcriptional regulation of heat shock gene expression in HeLa cells-information that provided a solid backdrop for our studies on the effects of riluzole in modulating the HSR and in regulating the amount and activity of HSF1–many of the experiments presented in this study were done using HeLa cells.
Regulation (regulating) of HSF1 in HeLa associated with shock
1) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.30 Pain Relevance 0.04
Effects of riluzole on the regulation and function of HSF1
Regulation (regulation) of HSF1
2) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.37 Pain Relevance 0.05
Reciprocal effects of pro-inflammatory stimuli and anti-inflammatory drugs on the activity of heat shock factor-1 in human monocytes.
Regulation (effects) of heat shock factor-1 in monocytes associated with inflammation, shock, cinod and inflammatory stimuli
3) Confidence 0.27 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 8954923 Disease Relevance 0.85 Pain Relevance 0.40
Our study provides novel insight into the mechanism that regulates HSF1 turnover, and identifies the degradation of HSF1 as a target for therapeutics intervention.



Regulation (regulates) of HSF1
4) Confidence 0.26 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2481402 Disease Relevance 0.48 Pain Relevance 0
Because of the wealth of literature information on the regulation and function of HSF1 and the robust transcriptional regulation of heat shock gene expression in HeLa cells-information that provided a solid backdrop for our studies on the effects of riluzole in modulating the HSR and in regulating the amount and activity of HSF1–many of the experiments presented in this study were done using HeLa cells.
Regulation (regulation) of HSF1 in HeLa associated with shock
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.35 Pain Relevance 0.03
These effects of riluzole appear to be ubiquitous in a variety of cell types/lines that we studied including the human HeLa cells–which we used as a model to evaluate the effects of riluzole on the regulation and function of HSF1, and spinal cord neurons–which we used to validate the relevance of these effects of riluzole.
Regulation (effects) of HSF1 in spinal cord neurons associated with spinal cord
6) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.13 Pain Relevance 0.05
Because of the wealth of literature information on the regulation and function of HSF1 and the robust transcriptional regulation of heat shock gene expression in HeLa cells-information that provided a solid backdrop for our studies on the effects of riluzole in modulating the HSR and in regulating the amount and activity of HSF1–many of the experiments presented in this study were done using HeLa cells.
Regulation (function) of HSF1 in HeLa associated with shock
7) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.34 Pain Relevance 0.03
The effect of riluzole on HSF1 was qualitatively different from that of MG132 and chloroquine, inhibitors of the proteasome and lysosome, respectively, and appeared to involve the chaperone-mediated autophagy pathway as RNAi-mediated knockdown of CMA negated its effect.


Spec (appeared) Regulation (effect) of HSF1
8) Confidence 0.26 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2481402 Disease Relevance 0.71 Pain Relevance 0
Importantly, such protein up-regulation in response to Hsp90 inhibition has thus far only been reported for certain other heat-shock proteins such as HSF1 and Hsp70.
Regulation (reported) of HSF1 associated with shock
9) Confidence 0.23 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.64 Pain Relevance 0

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