INT66922

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 6.58
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
spleen 2
Schwann cells 2
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 25 100.00 Very High Very High Very High
Inflammation 10 99.16 Very High Very High Very High
Eae 5 98.96 Very High Very High Very High
antidepressant 5 97.30 Very High Very High Very High
Sciatic nerve 3 95.80 Very High Very High Very High
cva 10 95.52 Very High Very High Very High
Antinociceptive 4 95.48 Very High Very High Very High
fluoxetine 4 94.84 High High
Inflammatory mediators 4 89.60 High High
Inflammatory response 3 78.08 Quite High
Disease Link Frequency Relevance Heat
Necrosis 5 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
Wallerian Degeneration 16 99.24 Very High Very High Very High
INFLAMMATION 15 99.16 Very High Very High Very High
Injury 8 98.96 Very High Very High Very High
Pressure And Volume Under Development 1 98.04 Very High Very High Very High
Hemorrhage 10 95.52 Very High Very High Very High
Encephalitis 2 93.76 High High
Pancreatitis 6 93.40 High High
Sepsis 8 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was, however, associated with increased mRNA expression for IL-1beta and IL-6 and increased serum corticosterone levels.
Positive_regulation (increased) of Transcription (expression) of IL-1beta
1) Confidence 0.49 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.80 Pain Relevance 0.39
This was, however, associated with increased mRNA expression for IL-1beta and IL-6 and increased serum corticosterone levels.
Positive_regulation (increased) of Transcription (expression) of IL-1beta
2) Confidence 0.49 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.80 Pain Relevance 0.39
Cerulein treatment increased mRNA expression of several proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) at 12 h with similar magnitude both in wild-type and PACAP-Tg mice.
Positive_regulation (increased) of Transcription (expression) of IL-1beta associated with cytokine
3) Confidence 0.49 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.93 Pain Relevance 0.27
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of Transcription (transcription) of interleukin-1beta associated with necrosis and cancer
4) Confidence 0.49 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.24
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of Transcription (transcription) of IL-1beta associated with necrosis and cancer
5) Confidence 0.49 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.24
The effects of antidepressants on the responsiveness to LPS are probably not mediated by their effects on peripheral proinflammatory cytokine production, because LPS-induced expression of TNFalpha and IL-1beta mRNA in the spleen (assessed by semiquantitative in situ hybridization) was not altered following chronic treatment with either fluoxetine or imipramine.
Positive_regulation (-) of Transcription (expression) of IL-1beta in spleen associated with antidepressant, fluoxetine and cytokine
6) Confidence 0.45 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11282253 Disease Relevance 0.48 Pain Relevance 0.55
IL-1beta mRNA expression and protein synthesis and secretion were induced sequentially in Schwann cells with a delay after injury.
Positive_regulation (induced) of Transcription (expression) of IL-1beta in Schwann cells associated with injury
7) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.44 Pain Relevance 0.30
We found an ipsilateral upregulation of TNF, IL-1beta and IL-10 mRNA levels as early as one hour after CCI.
Positive_regulation (upregulation) of Transcription (levels) of IL-1beta associated with eae
8) Confidence 0.45 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.08 Pain Relevance 0.74

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