INT66923

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Context Info
Confidence 0.07
First Reported 1996
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 54
Total Number 57
Disease Relevance 19.78
Pain Relevance 20.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ik)
Anatomy Link Frequency
T cell 9
astrocytes 6
macrophages 2
colon 2
adipocytes 2
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2208 100.00 Very High Very High Very High
Inflammation 1135 100.00 Very High Very High Very High
Morphine 1328 99.84 Very High Very High Very High
opiate 306 99.04 Very High Very High Very High
Arthritis 49 98.64 Very High Very High Very High
Inflammatory response 103 97.12 Very High Very High Very High
Inflammatory mediators 22 90.72 High High
endometriosis 128 89.72 High High
cva 12 88.24 High High
chemokine 218 86.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1050 100.00 Very High Very High Very High
Cancer 60 99.92 Very High Very High Very High
Obesity 126 99.84 Very High Very High Very High
Necrosis 72 99.68 Very High Very High Very High
Hemorrhagic Shock 4 99.58 Very High Very High Very High
Apoptosis 1028 99.16 Very High Very High Very High
Arthritis 60 98.64 Very High Very High Very High
Colitis 307 98.22 Very High Very High Very High
Dengue 128 98.00 Very High Very High Very High
Sepsis 8 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our studies, we evaluated the therapeutic efficacy of whole-cell vaccine based on irradiated murine RENCA cells genetically modified to secrete designer cytokine--Hyper-IL6 (H6)--comprising IL-6 and soluble IL-6 receptor.
Localization (secrete) of cytokine associated with cytokine
1) Confidence 0.07 Published 2010 Journal Cancer Gene Ther. Section Abstract Doc Link 20168352 Disease Relevance 0.62 Pain Relevance 0.16
Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis.
Localization (release) of cytokine in macrophage associated with hemorrhagic shock, sepsis and cytokine
2) Confidence 0.05 Published 1996 Journal J. Immunol. Section Title Doc Link 8955229 Disease Relevance 0.55 Pain Relevance 0.33
Following prolactin treatment of hemorrhaged mice, IL-1beta and IL-6 mRNA levels as well as cytokine release capacity and blood corticosterone levels were comparable to the values in sham animals.
Localization (release) of cytokine in blood associated with cytokine
3) Confidence 0.05 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.80 Pain Relevance 0.39
PM of TM-stimulated and control mice were isolated from the PF and cultured in vitro to examine their cytokine secretion.
Spec (examine) Localization (secretion) of cytokine associated with cytokine
4) Confidence 0.03 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2569845 Disease Relevance 0.39 Pain Relevance 0.33
The cytokine leptin, for example, is secreted by adipocytes and has strong angiogenic features (Sierra-Honigmann et al., 1998).
Localization (secreted) of cytokine in adipocytes associated with obesity and cytokine
5) Confidence 0.03 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2569845 Disease Relevance 0.33 Pain Relevance 0.14
The cytokine IL-10, released by resident peritoneal macrophages, plays a regulatory anti-inflammatory role in the recruitment of leukocytes in murine models of peritoneal inflammation [22,24].
Localization (released) of cytokine in leukocytes associated with inflammation and cytokine
6) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.03 Pain Relevance 0.62
IL-4 is the hallmark cytokine of the Th2 phenotype, but IL-10 is secreted by Th2 cells and a number of the recently identified Treg populations that play a crucial role in limiting inflammation [25,26].
Localization (secreted) of cytokine in Th2 cells associated with inflammation and cytokine
7) Confidence 0.02 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.15 Pain Relevance 0.14
or 72 h (in the case of IL-10 and IL-4), which are the times of maximum cytokine release [27]; they were then stored frozen at -80°C for cytokine analysis.
Localization (release) of cytokine associated with cytokine
8) Confidence 0.02 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.19 Pain Relevance 0.18
Interleukin-10 (IL-10) was first noted as a cytokine synthesis inhibitory factor (CSIF) that is secreted by TH2 cells and suppresses the activity of TH1 cells [18].
Localization (secreted) of cytokine associated with cytokine
9) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.48 Pain Relevance 0.13
IL-10 has potent immunoregulatory activity, suppressing proinflammatory cytokine secretion and activation of antigen-presenting cells - functions which result in suppressed NK cell and T cell activity [46].
Localization (secretion) of cytokine in NK cell associated with cytokine
10) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.07 Pain Relevance 0.09
Innate immunity is activated in hearts injured in different ways, evident as cytokine release from the heart, activation of toll-like receptors involved in recognizing danger, and activation of the transcription factor nuclear factor kappa B.
Localization (release) of cytokine in heart associated with cytokine
11) Confidence 0.02 Published 2010 Journal Heart Fail Rev Section Abstract Doc Link PMC3003782 Disease Relevance 0.64 Pain Relevance 0.17
When these cells are stimulated with DENV1 derived peptides, 51% of the cells specific for DENV2 responded with either granulation or cytokine release (TNF?
Localization (release) of cytokine in granulation associated with cytokine
12) Confidence 0.01 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.52 Pain Relevance 0.05
In contrast to the typical cytokine profiles secreted by T helper cells these iNKT cells, which also may express CD4, are capable of producing large amounts of IL-4, IL-13, and IFN-?
Localization (secreted) of cytokine associated with cytokine
13) Confidence 0.01 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.73 Pain Relevance 0.15
There is a differential cytokine secretion in response to antigen exposure in CD4+ cells in Dengue infected donors.
Localization (secretion) of cytokine associated with dengue and cytokine
14) Confidence 0.01 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.63 Pain Relevance 0.09
Cytokine release could make an important
Localization (release) of Cytokine associated with cytokine
15) Confidence 0.01 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.85 Pain Relevance 0.18
Interestingly, however, increasing [Ca2+]i by itself is not sufficient to increase cytokine release.
Localization (release) of cytokine associated with cytokine
16) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.70
Despite increases in [Ca2+]i, morphine treatment alone did not increase cytokine release suggesting that an additional signal independent from Ca2+, such as the phosphorylation of NF-?
Localization (release) of cytokine associated with cytokine and morphine
17) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.71
Thus, while increasing [Ca2+]i may be necessary, it is not sufficient to induce cytokine release by astrocytes.
Localization (release) of cytokine in astrocytes associated with cytokine
18) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.67
serves as an initiator of cytokine release.
Localization (release) of cytokine associated with cytokine
19) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.09 Pain Relevance 0.35
Cytokine secretion was also affected by LMB.
Localization (secretion) of Cytokine associated with cytokine
20) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.07 Pain Relevance 0.85

General Comments

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