INT66924

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Context Info
Confidence 0.68
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 11.80
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
lung 6
chondrocytes 2
liver 2
neutrophils 2
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 186 100.00 Very High Very High Very High
agonist 26 99.78 Very High Very High Very High
Paracetamol 5 99.60 Very High Very High Very High
Inflammation 394 99.16 Very High Very High Very High
Inflammatory response 40 97.80 Very High Very High Very High
chemokine 22 97.12 Very High Very High Very High
Infliximab 32 95.84 Very High Very High Very High
cva 13 95.52 Very High Very High Very High
Chronic pancreatitis 5 71.68 Quite High
Morphine 2 63.60 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 351 100.00 Very High Very High Very High
Apoptosis 24 100.00 Very High Very High Very High
INFLAMMATION 420 99.16 Very High Very High Very High
Injury 33 99.10 Very High Very High Very High
Leukemia 4 98.76 Very High Very High Very High
Necrosis 15 98.44 Very High Very High Very High
Pressure And Volume Under Development 10 98.04 Very High Very High Very High
Disorders Of The Lacrimal System 29 97.76 Very High Very High Very High
Hemorrhage 17 95.52 Very High Very High Very High
Psoriasis 41 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following the induction of liver injury with acetaminophen (APAP), a time-dependent increase in liver mRNA expression of IL-6 and its family members IL-11, leukemia inhibitory factor, and oncostatin M was observed in wild type (WT) mice, suggesting a possible hepatoprotective role played by this cytokine family.
Positive_regulation (increase) of Transcription (expression) of IL-6 in liver associated with leukemia, paracetamol, injury and cytokine
1) Confidence 0.68 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12705907 Disease Relevance 0.58 Pain Relevance 0.46
This was, however, associated with increased mRNA expression for IL-1beta and IL-6 and increased serum corticosterone levels.
Positive_regulation (increased) of Transcription (expression) of IL-6
2) Confidence 0.58 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.80 Pain Relevance 0.39
We found that IL-6 protein and mRNA levels were considerably higher in quiescent cultured PA-SMCs than in P-ECs (1.5 ± 0.56 vs. 29.3 ± 5 ng/?
Positive_regulation (higher) of Transcription (levels) of IL-6 protein
3) Confidence 0.50 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.63 Pain Relevance 0.08
induces transcription of a panel of genes, including IL-6 and RANTES, whereas NF?
Positive_regulation (including) of Transcription (transcription) of IL-6
4) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.08 Pain Relevance 0.09
induces transcription of a panel of genes, including IL-6 and RANTES, whereas NF?
Positive_regulation (induces) of Transcription (transcription) of IL-6
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.08 Pain Relevance 0.09
In contrast, levels of lung IL-6 receptor and gp 130 mRNA, which were markedly increased after 1 week of hypoxia, remained elevated after 2 weeks of hypoxia (Figure 2d).
Positive_regulation (elevated) of Transcription (levels) of IL-6 in lung associated with hypoxia
6) Confidence 0.47 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.16 Pain Relevance 0
In contrast, levels of lung IL-6 receptor and gp 130 mRNA, which were markedly increased after 1 week of hypoxia, remained elevated after 2 weeks of hypoxia (Figure 2d).
Positive_regulation (increased) of Transcription (levels) of IL-6 in lung associated with hypoxia
7) Confidence 0.47 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.07 Pain Relevance 0
IL-6, in the presence of sIL-6R, induced TIMP-1 mRNA and protein expression in cultured human chondrocytes and synovial fibroblasts [58].
Positive_regulation (induced) of Transcription (expression) of IL-6 in chondrocytes
8) Confidence 0.45 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.64 Pain Relevance 0.03
Cyclosporine is a calcineurin inhibitor that was reported to increase IL-6 production and IL-6 mRNA expression [24].
Positive_regulation (increase) of Transcription (expression) of IL-6
9) Confidence 0.43 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 0.70 Pain Relevance 0.21
This was, however, associated with increased mRNA expression for IL-1beta and IL-6 and increased serum corticosterone levels.
Positive_regulation (increased) of Transcription (expression) of IL-6
10) Confidence 0.42 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.80 Pain Relevance 0.39
Lung IL-6 receptor and gp 130 (the IL-6 signal transducer) mRNA levels increased after 1 and 2 weeks' hypoxia.
Positive_regulation (increased) of Transcription (levels) of IL-6 in Lung associated with hypoxia
11) Confidence 0.41 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2644669 Disease Relevance 1.73 Pain Relevance 0.17
Cerulein treatment increased mRNA expression of several proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) at 12 h with similar magnitude both in wild-type and PACAP-Tg mice.
Positive_regulation (increased) of Transcription (expression) of IL-6 associated with cytokine
12) Confidence 0.39 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.93 Pain Relevance 0.27
The high IL-6-inducing activity found in samples before treatment was strongly reduced in samples obtained 4 hours after the first infusion, following TNF-?
Positive_regulation (following) of Transcription (found) of IL-6-inducing
13) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.12 Pain Relevance 0.29
A twofold increase in IL-17A+ cells was observed in splenocytes, and increased apoptosis and transcriptional levels of IL-6 and IFN-?
Positive_regulation (increased) of Transcription (levels) of IL-6 associated with apoptosis
14) Confidence 0.35 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.15 Pain Relevance 0.07
Exogenous ATP increase significantly the expression of MIP-2 and IL-6 mRNA within 60 min after its intratracheal instillation, and the simultaneous administration of PPADS and ATP inhibited the expression of these genes (Figure 3A).
Positive_regulation (increase) of Transcription (expression) of IL-6
15) Confidence 0.29 Published 2008 Journal Respir Res Section Body Doc Link PMC2627837 Disease Relevance 0.39 Pain Relevance 0.29
For example, extracellular ATP, an agonist of P2RY2, induced IL-6 transcription in human monocyte-derived macrophages [28] and chemotaxis in human neutrophils [29], while the P2RY1 agonist 2-methylthio ATP increased IL-6 secretion from mouse splenocytes [30].
Positive_regulation (induced) of Transcription (transcription) of IL-6 in neutrophils associated with agonist
16) Confidence 0.13 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.10 Pain Relevance 0.18
These transcription factors normally induce the transcription of proinflammatory genes, such as cytokines (IL-6, TNF-?)
Positive_regulation (induce) of Transcription (transcription) of IL-6 associated with cytokine
17) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.42 Pain Relevance 0.26
These transcription factors normally induce the transcription of proinflammatory genes, such as cytokines (IL-6, TNF-?)
Positive_regulation (induce) of Transcription (transcription) of IL-6 associated with cytokine
18) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.42 Pain Relevance 0.26

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