INT66926

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 13.16
Pain Relevance 7.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
Spleen 2
liver 1
sciatic nerve 1
RAW 264 1
skin 1
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 45 100.00 Very High Very High Very High
Inflammation 30 100.00 Very High Very High Very High
Sciatic nerve 9 99.36 Very High Very High Very High
gABA 8 99.32 Very High Very High Very High
Eae 10 98.88 Very High Very High Very High
antagonist 4 98.44 Very High Very High Very High
antidepressant 5 97.12 Very High Very High Very High
Spinal cord 2 96.72 Very High Very High Very High
shoulder pain 5 95.28 Very High Very High Very High
cva 5 94.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 30 100.00 Very High Very High Very High
Necrosis 7 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Rheumatoid Arthritis 1 99.72 Very High Very High Very High
Wallerian Degeneration 32 99.24 Very High Very High Very High
Injury 19 98.88 Very High Very High Very High
Synovitis 4 98.68 Very High Very High Very High
Pressure And Volume Under Development 5 97.44 Very High Very High Very High
Disease 7 96.28 Very High Very High Very High
Nociception 11 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was, however, associated with increased mRNA expression for IL-1beta and IL-6 and increased serum corticosterone levels.
Transcription (expression) of IL-1beta
1) Confidence 0.69 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.80 Pain Relevance 0.39
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Transcription (transcription) of IL-1beta associated with necrosis and cancer
2) Confidence 0.69 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.52 Pain Relevance 0.24
Cerulein treatment increased mRNA expression of several proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) at 12 h with similar magnitude both in wild-type and PACAP-Tg mice.
Transcription (expression) of IL-1beta associated with cytokine
3) Confidence 0.69 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.93 Pain Relevance 0.27
It was observed that GABA significantly inhibited the mRNA expression of iNOS, IL-1beta, and TNF-alpha, in LPS-stimulated RAW 264.7 cells.
Transcription (expression) of IL-1beta in RAW 264 associated with gaba
4) Confidence 0.69 Published 2007 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18156782 Disease Relevance 0.52 Pain Relevance 0.44
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Transcription (transcription) of interleukin-1beta associated with necrosis and cancer
5) Confidence 0.69 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.52 Pain Relevance 0.24
Spleen cells from withdrawn mice also showed decreased mRNA levels of IL-1beta, IL-1-Ra, and TNF-alpha and a suppression of co-stimulatory molecule expression.
Transcription (levels) of IL-1beta in Spleen associated with rheumatoid arthritis
6) Confidence 0.69 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741440 Disease Relevance 0.10 Pain Relevance 0.24
To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR).
Transcription (expression) of IL-1beta in sciatic nerve associated with necrosis, inflammation, cancer, eae, injury, sciatic nerve and cytokine
7) Confidence 0.67 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.14 Pain Relevance 0.75
In contrast to rapid-WD, the production of TNFalpha, IL-1alpha, and IL-1beta protein was deficient in slow-WD, although their mRNAs were expressed. mRNA expression and protein production of TNFalpha, IL-1alpha, and IL-1beta were differentially regulated during rapid-WD and slow-WD, suggesting that mRNA expression, by itself, is no indication of the functional involvement of cytokines in WD.
Transcription (expression) of IL-1beta associated with wallerian degeneration and cytokine
8) Confidence 0.67 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.32 Pain Relevance 0.26
We found an ipsilateral upregulation of TNF, IL-1beta and IL-10 mRNA levels as early as one hour after CCI.
Transcription (levels) of IL-1beta associated with eae
9) Confidence 0.52 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.07 Pain Relevance 0.74
The effects of antidepressants on the responsiveness to LPS are probably not mediated by their effects on peripheral proinflammatory cytokine production, because LPS-induced expression of TNFalpha and IL-1beta mRNA in the spleen (assessed by semiquantitative in situ hybridization) was not altered following chronic treatment with either fluoxetine or imipramine.
Transcription (expression) of IL-1beta in spleen associated with antidepressant, fluoxetine and cytokine
10) Confidence 0.52 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11282253 Disease Relevance 0.48 Pain Relevance 0.55
Human MSCs reduced the mRNA levels of the pro-inflammatory interleukin IL-1beta mouse gene, as well as the neural beta-galactosidase over-activation in prefrontal cortex of SNI mice.
Transcription (levels) of IL-1beta in prefrontal associated with inflammation
11) Confidence 0.52 Published 2010 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19937263 Disease Relevance 1.15 Pain Relevance 0.66
It also inhibited TNF-alpha and IL-1beta mRNA expression, and increased IL-10 mRNA expression in LPS-treated murine liver.
Transcription (expression) of IL-1beta in liver
12) Confidence 0.52 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19878665 Disease Relevance 0.26 Pain Relevance 0.59
IL-1beta mRNA expression and protein synthesis and secretion were induced sequentially in Schwann cells with a delay after injury.
Transcription (expression) of IL-1beta in Schwann cells associated with injury
13) Confidence 0.52 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.43 Pain Relevance 0.29
Consequently, proinflammatory cytokine mRNA expression (IL-1beta, IL-6, and TNFalpha) levels were greater in skin, dorsal root ganglia (DRG), and spinal cord, whereas the anti-inflammatory cytokine (IL-10) level was lower in skin and DRG in CCL2 overexpressing mice than in control mice.
Transcription (expression) of IL-1beta in skin associated with inflammation, spinal cord and cytokine
14) Confidence 0.52 Published 2007 Journal Neuroscience Section Abstract Doc Link 17870246 Disease Relevance 0.96 Pain Relevance 0.86
Consequently, proinflammatory cytokine mRNA expression (IL-1beta, IL-6, and TNFalpha) levels were greater in skin, dorsal root ganglia (DRG), and spinal cord, whereas the anti-inflammatory cytokine (IL-10) level was lower in skin and DRG in CCL2 overexpressing mice than in control mice.
Transcription (expression) of IL-1beta in dorsal root ganglia associated with inflammation, spinal cord and cytokine
15) Confidence 0.18 Published 2007 Journal Neuroscience Section Abstract Doc Link 17870246 Disease Relevance 0.96 Pain Relevance 0.86
The mRNA expression levels of interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonists produced in the synovitis reflect the magnitude of inflammation.
Transcription (expression) of interleukin-1beta associated with inflammation, antagonist and synovitis
16) Confidence 0.00 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12472254 Disease Relevance 0.99 Pain Relevance 0.42

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