INT66929

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Context Info
Confidence 0.25
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.68
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
mast cells 2
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Inflammation 7 99.44 Very High Very High Very High
endometriosis 12 97.76 Very High Very High Very High
Crohn's disease 1 96.68 Very High Very High Very High
fibrosis 1 95.92 Very High Very High Very High
Spinal cord 4 93.68 High High
cytokine 1 91.08 High High
Pain 4 86.84 High High
Dismenorea 2 76.04 Quite High
Disease Link Frequency Relevance Heat
Disease 6 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
INFLAMMATION 8 99.44 Very High Very High Very High
Syndrome 1 98.72 Very High Very High Very High
Endometriosis 14 97.76 Very High Very High Very High
Collagenous Colitis 1 97.64 Very High Very High Very High
Fibrosis 1 95.92 Very High Very High Very High
Injury 1 94.52 High High
Nociception 8 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two forms of COX have been identified: COX-1, which is constitutively expressed in most tissues and organs, and COX-2, which is an inducible enzyme and is localized primarily in inflammatory cells and tissues.
Positive_regulation (inducible) of Localization (localized) of COX associated with inflammation
1) Confidence 0.25 Published 1996 Journal Brain Res. Section Abstract Doc Link 8955930 Disease Relevance 0.35 Pain Relevance 0.17
Two forms of COX have been identified: COX-1, which is constitutively expressed in most tissues and organs, and COX-2, which is an inducible enzyme and is localized primarily in inflammatory cells and tissues.
Positive_regulation (inducible) of Localization (localized) of COX associated with inflammation
2) Confidence 0.25 Published 1996 Journal Brain Res. Section Abstract Doc Link 8955930 Disease Relevance 0.35 Pain Relevance 0.17
We isolated a dibenzylbutyrolactone diterpene acid, 7-oxosandaracopimaric acid (OSA), from the ether fraction of Aralia cordata MeOH extract, and studied the effect of OSA on phenylquinone (PQ)-induced writhing syndrome and PQ-induced capillary permeability increase, compound 48/80-induced histamine release by peritoneal mast cells, cycloxygenase (COX) activities, and silica-induced RAW 264.7 cell reactive oxygen species production.
Positive_regulation (induced) of Localization (release) of COX in mast cells associated with syndrome
3) Confidence 0.04 Published 2010 Journal Arch. Pharm. Res. Section Abstract Doc Link 20422358 Disease Relevance 0.61 Pain Relevance 0.24
The pathogenesis of endometriosis is still unclear and numerous immunological and inflammatory factors have been suggested to be involved in the development of the disease, including interleukin (IL)-1, IL-2, IL-6, IL-8, IL-12, tumour necrosis factor -alpha (TNF-alpha), regulated on activation, normal T-Cell expressed and secreted (RANTES) and its receptor cognate chemokine receptor 1 (CCR1), peroxisome proliferator activated receptors (PPARs), matrix metalloproteinases (MMPs) and cyclooxygenase (COX).
Positive_regulation (including) of Localization (secreted) of COX associated with chemokine, endometriosis, necrosis, inflammation, cancer, metalloproteinase and disease
4) Confidence 0.01 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18393858 Disease Relevance 1.33 Pain Relevance 0.54
The pathogenesis of endometriosis is still unclear and numerous immunological and inflammatory factors have been suggested to be involved in the development of the disease, including interleukin (IL)-1, IL-2, IL-6, IL-8, IL-12, tumour necrosis factor -alpha (TNF-alpha), regulated on activation, normal T-Cell expressed and secreted (RANTES) and its receptor cognate chemokine receptor 1 (CCR1), peroxisome proliferator activated receptors (PPARs), matrix metalloproteinases (MMPs) and cyclooxygenase (COX).
Positive_regulation (development) of Localization (secreted) of COX associated with chemokine, endometriosis, necrosis, inflammation, cancer, metalloproteinase and disease
5) Confidence 0.01 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18393858 Disease Relevance 1.34 Pain Relevance 0.54
Through cyclooxygenase (COX)-1 and COX-2 activation, ISEMF augment intestinal ion secretion in response to certain secretagogues.
Positive_regulation (augment) of Localization (secretion) of COX
6) Confidence 0.01 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10444394 Disease Relevance 0.70 Pain Relevance 0.32

General Comments

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